Design and synthesis of a novel spinnable polyborazine precursor with high ceramic yield via one‐pot copolymerization

2021 ◽  
Author(s):  
Yiang Du ◽  
Bing Wang ◽  
Wei Li ◽  
Quzhi Song ◽  
Changwei Shao ◽  
...  
Keyword(s):  
Ceramic Yield ◽  
One Pot ◽  
Design And Synthesis

Design and Synthesis of Cu/ZSM-5 Catalyst via a Facile One-Pot Dual-Template Strategy with Controllable Cu Content for Removal of NOx

2018 ◽  
Vol 57 (44) ◽  
pp. 14967-14976 ◽  
Author(s):  
Cheng Peng ◽  
Jian Liang ◽  
Honggen Peng ◽  
Ran Yan ◽  
Wenming Liu ◽  
...  
Keyword(s):  
One Pot ◽  
Cu Content ◽  
Design And Synthesis

scholarly journals DESIGN AND SYNTHESIS OF MOLECULAR TWEEZER BASED ON 3-HYDROXYFLAVONE FOR THE DETECTION OF ATP

2017 ◽  
pp. 67-70
Author(s):  
O. Bugera ◽  
A. Netrebchuk ◽  
V. Pivovarenko
Keyword(s):  
Amino Acid ◽  
Hydrogen Bonds ◽  
Atmospheric Oxygen ◽  
High Sensitivity ◽  
Fluorescence Probes ◽  
Amino Acid Derivative ◽  
One Pot ◽  
Design And Synthesis ◽  
Sensitivity And Selectivity ◽  
Molecular Tweezer

Adenosine 5'-triphosphate (ATP) is known as a universal energy source and signaling mediator in numerous biological processes. Among the methods for its determination, molecular fluorescence probes occupy leading positions due to high sensitivity and selectivity. Recently we have shown that 31 of 33 tested flavones and quinolones of various structures give fluorescence response and can be effectively applied as the probes in aqueous solutions for detection of ATP in 1–50,000 μM range of its concentrations. To increase response parameters of a probe in respect to ATP we have synthesized N,N'-(butane-1,4-diyl)bis(2-((2-(4-(dimethylamino)phenyl)-3-hydroxy-4-oxo-4H-chromene-6-yl)oxy)acetamide, the molecular tweezer composed of two flavonol units connected by active linker. On our idea, being equipped by two planar platforms, the tweezershould demonstrate increased affinity and selectivity to ATP in a result of increased number of hydrogen bonds and increased stacking interactions. Having two NH-amide groups the amino acid linker will form hydrogen bonds with the phosphates of ATP, increasing the portion of probe-ATP complex population in the reporting conformation.In the four-step synthesis of this molecular device, starting from methyl 2-(3-acetyl-4-hydroxyphenoxy)acetate and N,N-dimethylaminobenzaldehyde, the conditions for the reaction of one-pot chalcone formation and its oxidative heterocyclization in the presence of an organic base were found, which resulted in the isolation of a target flavonol-amino acid derivative with high yields. We suggest that atmospheric oxygen was an oxidizer in this process. The obtained derivative was converted intotarget compound by dual condensation with 1,4-butane diamine.

scholarly journals Design and Synthesis of Various 5′-Deoxy-5′-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of Mycobacterium tuberculosis Mur Ligases

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4953
Author(s):  
Vincent Hervin ◽  
Ritu Arora ◽  
Jyoti Rani ◽  
Srinivasan Ramchandran ◽  
Urmi Bajpai ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Docking ◽  
Active Site ◽  
Inhibitory Effect ◽  
Natural Substrate ◽  
Screening Assay ◽  
One Pot ◽  
Peptidoglycan Biosynthesis ◽  
Design And Synthesis ◽  
Structure Activity

The synthesis of hitherto unknown 5′-deoxy-5′-(4-substituted-1,2,3-triazol-1-yl)-uridine and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved in Mycobacterium tuberculosis (Mtb), are described. Starting from UDP-N-acetylmuramic acid (UDP-MurNAc), the natural substrate involved in the peptidoglycan biosynthesis, our strategy was to substitute the diphosphate group of UDP-MurNAc by a 1,2,3-triazolo spacer under copper-catalyzed azide-alkyne cycloaddition conditions. The structure-activity relationship was discussed and among the 23 novel compounds developed, N-acetylglucosamine analogues 11c and 11e emerged as the best inhibitors against the Mtb MurA-F enzymes reconstruction pathway with an inhibitory effect of 56% and 50%, respectively, at 100 μM. Both compounds are selective inhibitors of Mtb MurE, the molecular docking and molecular dynamic simulation suggesting that 11c and 11e are occupying the active site of Mtb MurE ligase.

scholarly journals A precise polyrotaxane synthesizer

Science ◽  
2020 ◽  
Vol 368 (6496) ◽  
pp. 1247-1253 ◽  
Author(s):  
Yunyan Qiu ◽  
Bo Song ◽  
Cristian Pezzato ◽  
Dengke Shen ◽  
Wenqi Liu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Assembly Line ◽  
Molecular Machines ◽  
One Pot ◽  
Interlocked Molecules ◽  
Design And Synthesis ◽  
Redox Cycles

Mechanically interlocked molecules are likely candidates for the design and synthesis of artificial molecular machines. Although polyrotaxanes have already found niche applications in exotic materials with specialized mechanical properties, efficient synthetic protocols to produce them with precise numbers of rings encircling their polymer dumbbells are still lacking. We report the assembly line–like emergence of poly[n]rotaxanes with increasingly higher energies by harnessing artificial molecular pumps to deliver rings in pairs by cyclical redox-driven processes. This programmable strategy leads to the precise incorporation of two, four, six, eight, and 10 rings carrying 8+, 16+, 24+, 32+, and 40+ charges, respectively, onto hexacationic polymer dumbbells. This strategy depends precisely on the number of redox cycles applied chemically or electrochemically, in both stepwise and one-pot manners.

One-pot aqueous phase synthesis of peptide–CdTe quantum dots

RSC Advances ◽  
2014 ◽  
Vol 4 (38) ◽  
pp. 20044-20047 ◽  
Author(s):  
Cuiling Zhang ◽  
Yuanyuan Zu ◽  
Xinghu Ji ◽  
Zhike He
Keyword(s):  
Quantum Dots ◽  
Aqueous Phase ◽  
High Salt ◽  
Cdte Quantum Dots ◽  
Salt Solutions ◽  
One Pot ◽  
Phase Synthesis ◽  
Short Peptide ◽  
Design And Synthesis ◽  
Excellent Stability

We report the design and synthesis of short peptide (hexapeptide)-capped CdTe quantum dots (peptide–QDs) by a one-pot method with excellent stability in acidic and high salt solutions.

Single-source-precursor Synthesis and High-temperature Behavior of SiC Ceramics Containing Boron

2014 ◽  
Vol 33 (6) ◽  
pp. 563-570 ◽  
Author(s):  
Miaomiao Gui ◽  
Yunhui Fang ◽  
Zhaoju Yu
Keyword(s):  
High Temperature ◽  
Temperature Behavior ◽  
Ceramic Yield ◽  
One Pot ◽  
High Temperature Behavior ◽  
Sic Ceramics ◽  
Sic Ceramic ◽  
Single Source Precursor ◽  
Ceramic Microstructure ◽  
Ft Ir

AbstractIn this paper, a hyperbranched polyborocarbosilane (HPBCS) was prepared by a one-pot synthesis with Cl2Si(CH3)CH2Cl, Cl3SiCH2Cl and BCl3 as the starting materials. The obtained HPBCS was characterized by GPC, FT-IR and NMR, and was confirmed to have hyperbranched structures. The thermal property of the resulting HPBCS was investigated by TGA. The ceramic yield of the HPBCS is about 84% and that of the counterpart hyperbranched hydridopolycarbosilane is only 45%, indicating that the introduction of boron into the preceramic polymer significantly improved the ceramic yield. With the polymer-derived ceramic route, the final ceramics were annealed at 1800 °C in argon atmosphere for 2 h in order to characterize the microstructure and to evaluate the high-temperature behavior. The final ceramic microstructure was studied by XRD and SEM, indicating that the introduction of boron dramatically inhibits SiC crystallization. The boron-containing SiC ceramic shows excellent high-temperature behavior against decomposition and crystallization at 1800 °C.

scholarly journals Formation of Bifunctional Octasilsesquioxanes via Silylative Coupling and Cross-Metathesis Reaction

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 3966
Author(s):  
Małgorzata Bołt ◽  
Patrycja Żak ◽  
Beata Dudziec ◽  
Anna Schulmann ◽  
Bogdan Marciniec
Keyword(s):  
Functional Materials ◽  
Metathesis Reaction ◽  
One Pot ◽  
Intermediate Products ◽  
Design And Synthesis ◽  
Cross Metathesis ◽  
Synthetic Procedure ◽  
Wide Range ◽  
Potential Applications ◽  
New Compounds

Bifunctional silsesquioxanes create an attractive group of compounds with a wide range of potential applications, and recently they have gained much interest. They are known to be obtained mainly via hydrosilylation, but we disclose novel synthetic protocols based on different but complementary reactions, i.e., cross-metathesis (CM) and silylative coupling (SC). A series of cubic T8 type silsesquioxane derivatives with a broad scope of styryl substituents were synthesized in a one-pot procedure and characterized by spectroscopic and spectrometric methods. All of the new compounds can be obtained in a one-pot manner, which has an attractive impact on the synthetic procedure, as it is economic in terms of the isolation of intermediate products. Additionally, the methodology disclosed here enables the (E)-stereoselective introduction of styrenes derivative to the cubic T8 type core. The presented compounds can be interesting precursors for a further functionalization that may significantly increase the possibility of their application in the design and synthesis of new functional materials.

Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One-Pot Multienzyme Systems

2013 ◽  
Vol 125 (45) ◽  
pp. 12068-12072 ◽  
Author(s):  
Yi Chen ◽  
Yanhong Li ◽  
Hai Yu ◽  
Go Sugiarto ◽  
Vireak Thon ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
One Pot ◽  
Design And Synthesis ◽  
Tailored Design
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