scholarly journals Clinical application and efficacy of negative pressure wound therapy with instillation and dwell time ( NPWTi ‐d): A systematic review and meta‐analysis

2020 ◽  
Vol 17 (6) ◽  
pp. 1948-1959
Author(s):  
Muholan Kanapathy ◽  
Angelos Mantelakis ◽  
Natasha Khan ◽  
Ibby Younis ◽  
Afshin Mosahebi
Keyword(s):  
Systematic Review ◽  
Clinical Application ◽  
Negative Pressure ◽  
Dwell Time ◽  
Negative Pressure Wound Therapy ◽  
Meta Analysis ◽  
Wound Therapy

225 Clinical application and efficacy of Negative Pressure Wound Therapy with Instillation and Dwell Time (NPWTi-d): A Systematic Review and Meta-Analysis

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Mantelakis
Keyword(s):  
Clinical Application ◽  
Negative Pressure ◽  
Dwell Time ◽  
Negative Pressure Wound Therapy ◽  
Meta Analysis ◽  
Complete Healing ◽  
Current Data ◽  
Wound Therapy ◽  
The Mean ◽  
Mean Time

Abstract Background This study evaluates the current clinical evidence of Negative Pressure Wound Therapy with Instillation and dwell time (NPWTi-d) to establish its clinical application and efficacy. Method MEDLINE, EMBASE, and CENTRAL databases were searched from 1946 to July 2019 for studies reporting clinical outcomes on wounds treated with NPWTi-d. The primary outcome was proportion of wounds with complete healing. The secondary outcomes were mean time for healing, NPWTi-d settings, cost, length of stay and adverse events. Results Thirteen articles were included with a total of 624 wounds in 542 patients involving wounds of various aetiology. The pooled proportion of wound that achieved complete healing was 93.65% (95%CI: 84.02-99.04). Normal saline was the most commonly used instillation solution with the mean dwell time of 14.23 minutes (95%CI: 10.88-17.59) and instillation cycle every 4.17 ± 2.32 hourly. The mean therapy duration was 10.69 days (95%CI: 10.46-10.91) with daily cost of $194.80. The mean hospital stay was 18.1 days (95%CI: 17.20-19.00). There were no severe adverse effects reported. Discussion NPWTi-d is an adjuntive therapy to aid complete healing of the vast majority of wounds. However, the current data is limited by the lack of level 1 evidence.

The Effectiveness of Negative Pressure Wound Therapy Versus Conventional Dressing in the Treatment of Open Fractures: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 34 (5) ◽  
pp. 223-230 ◽  
Author(s):  
Marc C. Grant-Freemantle ◽  
Éanna J. Ryan ◽  
Sean O. Flynn ◽  
Darren P. Moloney ◽  
Michael A. Kelly ◽  
...  
Keyword(s):  
Systematic Review ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Meta Analysis ◽  
Open Fractures ◽  
Wound Therapy
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