scholarly journals Effect on total microbial load and community composition with two vs six‐week topical Cadexomer Iodine for treating chronic biofilm infections in diabetic foot ulcers

2019 ◽  
Vol 16 (6) ◽  
pp. 1477-1486
Author(s):  
Matthew Malone ◽  
Saskia Schwarzer ◽  
Michael Radzieta ◽  
Thomas Jeffries ◽  
Annie Walsh ◽  
...  
Keyword(s):  
Community Composition ◽  
Diabetic Foot ◽  
Microbial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Determinants of Microbial Load in Infected Diabetic Foot Ulcers: A Pilot Study

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
M. Demetriou ◽  
N. Papanas ◽  
M. Panopoulou ◽  
K. Papatheodorou ◽  
E. Maltezos
Keyword(s):  
Pilot Study ◽  
Diabetic Foot ◽  
Microbial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

Quantification and relevance of the microbial load in diabetic foot ulcers

2000 ◽  
Vol 40 (2) ◽  
pp. A26
Author(s):  
I. Mantey ◽  
R.L.R. Hill ◽  
J.J. Wade ◽  
A.V.M. Foster ◽  
M. Bates ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Microbial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Clinical Signs of Infection in Diabetic Foot Ulcers With High Microbial Load

2009 ◽  
Vol 11 (2) ◽  
pp. 119-128 ◽  
Author(s):  
Sue E. Gardner ◽  
Stephen L. Hillis ◽  
Rita A. Frantz
Keyword(s):  
Diabetic Foot ◽  
Medical Center ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Microbial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Cross Sectional ◽  
Clinical Signs And Symptoms ◽  
Tissue Specimens

Aims. One proposed method to diagnose diabetic foot ulcers (DFUs) for infection is clinical examination. Twelve different signs of infection have been reported. The purpose of this study was to examine diagnostic validity of each individual clinical sign, a combination of signs recommended by the Infectious Disease Society of America (IDSA), and a composite predictor based on all signs of localized wound infection in identifying DFU infection, among a sample of DFUs. Methods. A cross-sectional research design was used. Sixty-four individuals with DFUs were recruited from a Department of Veterans Affairs Medical Center and an academic-affiliated hospital. Each DFU was independently assessed by 2 research team members using the clinical signs and symptoms checklist. Tissue specimens were then obtained via wound biopsy and quantitatively processed. Ulcers with more than 106 organisms per gram of tissue were defined as having high microbial load. Individual signs and the IDSA combination were assessed for validity by calculating sensitivity, specificity, and concordance probability. The composite predictor was analyzed using c-index and receiver operating curves. Results. Twenty-five (39%) of the DFUs had high microbial loads. No individual sign was a significant predictor of high microbial load. The IDSA combination was not a significant predictor either. The c-index of the composite predictor was .645 with a 95% confidence interval of .559-.732. Conclusions. Individual signs of infection do not perform well nor does the IDSA combination of signs. However, a composite predictor based on all signs provides a moderate level of discrimination, suggesting clinical use. Larger sample sizes and alternate reference standards are recommended.

scholarly journals Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo

2017 ◽  
Vol 72 (7) ◽  
pp. 2093-2101 ◽  
Author(s):  
M. Malone ◽  
K. Johani ◽  
S. O. Jensen ◽  
I. B. Gosbell ◽  
H. G. Dickson ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Microbial Load ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

Abstract #295 Epidemiologic and Clinical Characteristics of Diabetic Foot Ulcers – Report From South West Nigeria

2019 ◽  
Vol 25 ◽  
pp. 121-122
Author(s):  
Olufunmilayo Adeleye ◽  
Ejiofor Ugwu ◽  
Anthonia Ogbera ◽  
Akinola Dada ◽  
Ibrahim Gezawa ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Clinical Characteristics ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
South West
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