scholarly journals A single-arm trial indirect comparison investigation: a proof-of-concept method to predict venous leg ulcer healing time for a new acellular synthetic matrix matched to standard care control

2016 ◽  
Vol 14 (4) ◽  
pp. 729-741 ◽  
Author(s):  
Ronald Shannon ◽  
Andrea Nelson
Keyword(s):  
Ulcer Healing ◽  
Standard Care ◽  
Indirect Comparison ◽  
Healing Time ◽  
Leg Ulcer ◽  
Proof Of Concept ◽  
Venous Leg Ulcer ◽  
Synthetic Matrix

Venous leg ulcer healing time is increased with each subsequent bacterial strain identified in the ulcer. A retrospective study

2020 ◽  
pp. 026835552096194
Author(s):  
Karolina Kruszewska ◽  
Katarzyna Wesolowska-Gorniak ◽  
Bozena Czarkowska-Paczek
Keyword(s):  
Antibiotic Therapy ◽  
Ulcer Healing ◽  
Bacterial Strain ◽  
Bacterial Flora ◽  
Healing Time ◽  
Leg Ulcer ◽  
Leg Ulcers ◽  
Venous Leg Ulcer ◽  
Venous Leg Ulcers ◽  
Systemic Antibiotic Therapy

Objective The aim of the study was to analyze bacterial flora in venous leg ulcers, empiric and targeted antibiotic therapy, and factors influencing healing time. Materials and methods Data from 30 patients with venous leg ulcers were retrospectively analyzed. Collected data included: sociodemographic data, wounds information, number of comorbidities, results of the microbiological examination, and empiric and targeted antibiotic therapy. To compare the empiric and targeted treatment in terms of their compatibility, the group of patients was divided into the four subgroups: NEA (no empiric antibiotics), NA (no antibiotics), ETA+ (compatibility of empiric and targeted antibiotic), ETA− (no compatibility of empiric and targeted antibiotic). Results The average ulcer healing time was 163.4 ± 97.1 (range 51.0 to 426.0) days and increased by 28 days with each additional bacterial strain in the ulcer (p = 0.041). Healing time did not differ between the four groups. Staphylococcus aureus and Pseudomonas aeruginosa were the most frequent bacteria. Amoxicillinium/acidum clavulanicum was the most common empirical antibiotic and amoxicillinium/acidum clavulanicum, and levofloxacinum was the most common targeted antibiotic. Conclusions Venous leg ulcer healing time was prolonged with each subsequent bacterial strain in the ulcer, and it was independent from systemic antibiotic therapy.

Description of venous leg ulcer healing mechanism

Leczenie Ran ◽  
2015 ◽  
Vol 12 (2) ◽  
pp. 49-58
Author(s):  
Wojciech Twardokęs ◽  
Agata Kołodziej ◽  
Andrzej Ślęzak
Keyword(s):  
Ulcer Healing ◽  
Leg Ulcer ◽  
Venous Leg Ulcer

Effectiveness of two bundles in venous leg ulcer healing: A randomized controlled trial

2019 ◽  
Vol 37 (4) ◽  
pp. 232-245 ◽  
Author(s):  
Cynthia Assis de Barros Nunes ◽  
Paulla Guimarães Melo ◽  
Suelen Gomes Malaquias ◽  
Kelle Vanessa Álvares Amaral ◽  
Gabriela Rodrigues Alves ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Ulcer Healing ◽  
Controlled Trial ◽  
Leg Ulcer ◽  
Venous Leg Ulcer ◽  
Randomized Controlled

Controlling compression bandaging pressure in leg ulcer research trials: A summary of the literature

2019 ◽  
Vol 34 (8) ◽  
pp. 501-514 ◽  
Author(s):  
Sharon L Boxall ◽  
Keryln Carville ◽  
Gavin D Leslie ◽  
Shirley J Jansen
Keyword(s):  
Ulcer Healing ◽  
Gold Standard ◽  
Reliability And Validity ◽  
Leg Ulcer ◽  
Evidence Based ◽  
Leg Ulcers ◽  
Venous Leg Ulcer ◽  
Practice Recommendations ◽  
Compression Bandaging ◽  
Literature Searches

Compression bandaging remains the ‘gold standard’ intervention for the treatment of venous leg ulcers. Numerous studies have investigated the effect of a large variety of compression bandaging techniques and materials on venous leg ulcer healing. However, the majority of these studies failed to monitor both actual bandage application pressures and the bandaging competency of participating clinicians. A series of literature searches to explore the methods, practices, recommendations and results of monitoring compression bandaging pressures in leg ulcer research trials were undertaken. This included investigating the reliability and validity of sub-bandage pressure monitors and the degree to which compression bandaging achieves the recommended sub-bandage pressure. The literature revealed inconsistencies regarding the monitoring of sub-bandage pressure and in sub-bandage pressures produced by clinicians. This creates difficulties when comparing study outcomes and attempting to develop evidence-based practice recommendations.

The experience of self-management following venous leg ulcer healing

2014 ◽  
Vol 24 (9-10) ◽  
pp. 1300-1309 ◽  
Author(s):  
Suzanne Kapp ◽  
Charne Miller
Keyword(s):  
Ulcer Healing ◽  
Leg Ulcer ◽  
Self Management ◽  
Venous Leg Ulcer

Factors influencing concordance with compression stockings after venous leg ulcer healing

2004 ◽  
Vol 13 (3) ◽  
pp. 90-92 ◽  
Author(s):  
A.B. Jull ◽  
N. Mitchell ◽  
J. Aroll ◽  
M. Jones ◽  
J. Waters ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Leg Ulcer ◽  
Compression Stockings ◽  
Venous Leg Ulcer ◽  
Factors Influencing
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