scholarly journals Accelerated wound healing after wide excisions in Hidradenitis Suppurativa using autologous split-thickness skin grafting and platelet-rich plasma

2016 ◽  
Vol 14 (3) ◽  
pp. 583-586 ◽  
Author(s):  
Allard RJV Vossen ◽  
Hessel H van der Zee ◽  
Errol P Prens
Keyword(s):  
Wound Healing ◽  
Hidradenitis Suppurativa ◽  
Platelet Rich Plasma ◽  
Skin Grafting ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting

Utility of Porcine-Derived Xenograft as an Adjunct to Split-Thickness Skin Grafting in Lower-Extremity Wounds

2021 ◽  
Vol 111 (3) ◽  
Author(s):  
Jenna C. Bekeny ◽  
Christopher Kennedy ◽  
Jon D. Turissini ◽  
Iram Naz ◽  
Elliot T. Walters ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Hemoglobin A1c ◽  
Skin Grafting ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Patient Reported ◽  
Wound Bed Preparation ◽  
Future Work

Objective Porcine-derived xenograft biological dressings (PXBDs) are occasionally used to prepare chronic wound beds for definitive closure before split-thickness skin grafts (STSGs). We sought to determine whether PXBD influences rate of STSG take in lower-extremity wounds. Methods Lower-extremity wounds treated with STSGs were retrospectively reviewed. Patients were included in one of two groups: wound bed preparation with PXBD before STSG or no preparation. Patients were excluded if they received wound bed preparation via another method. Patient demographics, comorbidities, wound history, wound bed preparation, and 30- and 60-day outcomes were collected. Results There was no difference in healing outcomes between the PXBD (n = 27) and no preparation (n = 39) groups. At 30- and 60-day follow-up, percentage of STSG take was not significantly different between groups (77.9% versus 79.0%, P30 = .818; 82.2% versus 80.9%, P60 = .422). Mean wound sizes at these follow-up periods were not different (4.4 cm2 versus 5.1 cm2, P30 = .902; 1.2 cm2 versus 1.1 cm2, P60 = .689). The PXBD group had a higher mean ± SD hemoglobin A1c level (8.3 ± 3.5 versus 6.9 ± 1.6; P = .074) and age (64.9 ± 12.8 years versus 56.3 ± 11.9 years; P = .007) versus the no preparation group. Conclusions Application of PXBDs for wound bed preparation had no effect on wound healing compared with no wound bed preparation. The two groups varied only by mean age and hemoglobin A1c level. The PXBD may be beneficial, but these results call for randomized controlled trials to determine the true impact of PXBDs on wound healing. In addition, PXBDs may have utility outside of clinically oriented outcomes, and future work should address patient-reported outcomes and pain scores with this adjunct.

Reconstructive options in severe cases of Hidradenitis suppurativa

Open Medicine ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. 674-678 ◽  
Author(s):  
Birol Civelek ◽  
Kadir Aksoy ◽  
Esra Bilgen ◽  
Ibrahim İnal ◽  
Unal. Sahin ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Skin Grafting ◽  
Surgical Removal ◽  
Apocrine Glands ◽  
Reconstruction Methods ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Topical Antibacterial ◽  
Systemic Antibiotics

AbstractHidradenitis suppurativa is a chronic, debilitating inflammatory disease of apocrine glands characterized with abscesses and nodular lesions. The treatment of Hidradenitis suppurativa consists of topical antibacterial or antiseptic solutions, systemic antibiotics, steroids, hormonal therapy, anti-tumor necrosis factor, and various surgical procedures. In this report, we present a series of 14 cases with severe Hidradenitis suppurativa. Surgical options are reviewed to show the best outcomes in the long term. A total of 14 patients (9 female, 5 male) were treated for advanced cases of Hidradenitis suppurativa. They underwent excision of the affected regions followed by reconstruction. The reconstruction methods consisted of split-thickness skin grafting and various cutaneous and myocutaneous flaps. There was no flap necrosis or dehiscence. One patient developed contracture in the axilla, for which he underwent release surgery. There were recurrences in 4 cases. There was no limitation of the arm movements in cases with flap reconstruction. In the long-term, they were satisfied with the results. In conclusion, incision and drainage should be avoided because it is of limited value. Surgical removal of the involved tissue should be the first treatment of choice. Depending on the defect following excision, local flaps should be preferred over the grafts for recurrence prevention.

scholarly journals Reducing split-thickness skin grafting donor site agony; faster healing and decreased pain-role of platelet-rich plasma

2021 ◽  
Vol 15 (2) ◽  
pp. 195
Author(s):  
GhisulalM Choudhary ◽  
RakeshKumar Jain ◽  
Gajendra Gupta ◽  
AdityaN Patil ◽  
GautamD Prakash ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Donor Site ◽  
Skin Grafting ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting

scholarly journals Surgery for scar revision and reduction: from primary closure to flap surgery

2019 ◽  
Vol 7 ◽  
Author(s):  
Rei Ogawa
Keyword(s):  
Wound Healing ◽  
Review Paper ◽  
Surgical Techniques ◽  
Skin Grafting ◽  
Free Flaps ◽  
Flap Surgery ◽  
Reticular Dermis ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Atrophic Scars

Abstract Scars are the final result of the four processes that constitute cutaneous wound healing, namely, coagulation, inflammation, proliferation, and remodeling. Permanent scars are produced if the wounds reach the reticular dermis. The nature of these scars depends on the four wound healing processes. If the remodeling process is excessive, collagen degradation exceeds collagen synthesis and atrophic scars are produced. If the inflammation phase is prolonged and/or more potent for some reason, inflammatory/pathological scars such as keloids or hypertrophic scars can arise. If these pathological scars are located on joints or mobile regions, scar contractures can develop. When used with the appropriate timing and when selected on the basis of individual factors, surgical techniques can improve mature scars. This review paper focuses on the surgical techniques that are used to improve mature scars, burn scars, and scar contractures. Those methods include z-plasties, w-plasties, split-thickness skin grafting, full-thickness skin grafting, local flaps (including the square flap method and the propeller flap), and expanded flaps, distant flaps, regional flaps, and free flaps.

scholarly journals TO STUDY THE EFFICACY OF AUTOLOGOUS PLATELET RICH PLASMA OVER CONVENTIONAL MECHANICAL FIXATION METHODS IN SPLIT THICKNESS SKIN GRAFTING

2021 ◽  
pp. 1-4
Author(s):  
Ankur Deshwali ◽  
Peeyush Kesharwani ◽  
Rohan Gupta
Keyword(s):  
Skin Graft ◽  
Platelet Rich Plasma ◽  
Skin Grafting ◽  
Controlled Study ◽  
Study Group ◽  
Fixation Methods ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

TITLE Efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting . AIMS AND OBJECTIVES to determine the efficacy of autologous platelet rich plasma over conventional mechanical fixation methods in split thickness skin grafting. METHODS  This a prospective randomized controlled study, conducted in the Department of surgery, SAIMS Medical College and P.G Institute, Indore for a period of two years from September 2016 to September 2018. A total of 20 patients were included in the study, and divided into two groups of 10 each randomly. The study was approved by the local ethical committee of our hospital. An informed written consent was obtained from all patients.  Total of 20 patients were studied; 10 cases were randomly chosen for study with autologous platelet rich plasma and 10 cases received conventional methods like staples/sutures used to anchor the skin grafts in a control group. RESULTS Autologous PRP showed faster and better healing rates. With PRP study group instant graft adherence was seen in all cases. Hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in hospital were significantly less in the PRP. There were no adverse effects or reactions seen with the use of autologous PRP among the study group. CONCLUSION  The combination of PRP with Split Thickness Skin Graft (STSG) significantly improved clinical outcomes and shortened the wound healing time. Therefore, this treatment combination could provide a way to heal skin after skin graft reconstruction with minimal recovery time. It is found to be highly beneficial in many aspects both to the patient and surgeon based on our results.

scholarly journals One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay

2019 ◽  
Vol 7 ◽  
Author(s):  
Tong Liu ◽  
Chao Qiu ◽  
Chi Ben ◽  
Haihang Li ◽  
Shihui Zhu
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Skin Grafting ◽  
Skin Defect ◽  
Skin Grafts ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Split Thickness Skin Grafting

Abstract Background Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss. However, for patients with extensive burns, split-thickness skin grafting is limited by donor skin availability. Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality. Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds, but their application currently requires two surgeries. The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model. Methods A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old. The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac, respectively, were overlaid on minced split-thickness skin grafts to repair the defects. Wound healing rate and quality were compared between the two groups. For better illustration of the quality of wound healing, some results were compared with those obtained for normal skin of rats. Results We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis. In addition, this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation. Conclusions Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of full-thickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing.

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