scholarly journals Metabolic determinants of lupus pathogenesis

2020 ◽  
Vol 295 (1) ◽  
pp. 167-186 ◽  
Author(s):  
Xiangyu Teng ◽  
Josephine Brown ◽  
Seung‐Chul Choi ◽  
Wei Li ◽  
Laurence Morel
Keyword(s):  
Lupus Pathogenesis

scholarly journals A Novel Method for Real-Time, Continuous, Fluorescence-Based Analysis of Anti-DNA Abzyme Activity in Systemic Lupus

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Michelle F. Cavallo ◽  
Anna M. Kats ◽  
Ran Chen ◽  
James X. Hartmann ◽  
Mirjana Pavlovic
Keyword(s):  
Lupus Erythematosus ◽  
Molecular Mechanisms ◽  
Hydrolytic Activity ◽  
Disease Diagnosis ◽  
Response To Therapy ◽  
Systemic Lupus ◽  
Lupus Pathogenesis ◽  
Indirect Identification ◽  
Dna Antibodies ◽  
Novel Method

Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of antibodies against a variety of self-antigens including nucleic acids. These antibodies are cytotoxic, catalytic (hydrolyzing DNA, RNA, and protein), and nephritogenic. Current methods for investigating catalytic activities of natural abzymes produced by individuals suffering from autoimmunity are mostly discontinuous and often employ hazardous reagents. Here we demonstrate the utility of dual-labeled, fluorogenic DNA hydrolysis probes in highly specific, sensitive, continuous, fluorescence-based measurement of DNA hydrolytic activity of anti-ssDNA abzymes purified from the serum of patients suffering from SLE. An assay for the presence and levels of antibodies exhibiting hydrolytic activity could facilitate disease diagnosis, prediction of flares, monitoring of disease state, and response to therapy. The assay may allow indirect identification of additional targets of anti-DNA antibodies and the discovery of molecules that inhibit their activity. Combined, these approaches may provide new insights into molecular mechanisms of lupus pathogenesis.

A Genetic Model for IRF5, Autoantibodies, and Interferon Alpha in Human Lupus Pathogenesis

2009 ◽  
Vol 131 ◽  
pp. S4
Author(s):  
Timothy Niewold ◽  
Jennifer Kelly ◽  
Silvia Kariuki ◽  
Kenaz Thomas ◽  
Daniel Walker ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Genetic Model ◽  
Lupus Pathogenesis

scholarly journals The role of B cells in lupus pathogenesis

2010 ◽  
Vol 42 (4) ◽  
pp. 543-550 ◽  
Author(s):  
Emil Nashi ◽  
YingHua Wang ◽  
Betty Diamond
Keyword(s):  
B Cells ◽  
Lupus Pathogenesis

scholarly journals Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

1999 ◽  
Vol 103 (12) ◽  
pp. 1685-1695 ◽  
Author(s):  
Chandra Mohan ◽  
Laurence Morel ◽  
Ping Yang ◽  
Hiroshi Watanabe ◽  
Byron Croker ◽  
...  
Keyword(s):  
Genetic Dissection ◽  
Lupus Pathogenesis

scholarly journals Interferon regulatory factors in human lupus pathogenesis

2011 ◽  
Vol 157 (6) ◽  
pp. 326-331 ◽  
Author(s):  
Rafah Salloum ◽  
Timothy B. Niewold
Keyword(s):  
Regulatory Factors ◽  
Interferon Regulatory Factors ◽  
Lupus Pathogenesis
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