scholarly journals Using two phases of the CD 4 T cell response to blood‐stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection

2020 ◽  
Vol 293 (1) ◽  
pp. 88-114 ◽  
Author(s):  
Komi Gbedande ◽  
Victor H. Carpio ◽  
Robin Stephens
Keyword(s):  
Plasmodium Falciparum ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Falciparum Infection ◽  
Blood Stage ◽  
Placental Pathology ◽  
Systemic Immunity ◽  
Plasmodium Falciparum Infection ◽  
Two Phases

scholarly journals Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection

2018 ◽  
Vol 218 (7) ◽  
pp. 1119-1129 ◽  
Author(s):  
Chelsea L Edwards ◽  
Susanna S Ng ◽  
Dillon Corvino ◽  
Marcela Montes de Oca ◽  
Fabian de Labastida Rivera ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Falciparum Infection ◽  
Blood Stage ◽  
Cd4 T Cell ◽  
Plasmodium Falciparum Infection

scholarly journals The Spleen CD4+ T Cell Response to Blood-Stage Plasmodium chabaudi Malaria Develops in Two Phases Characterized by Different Properties

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22434 ◽  
Author(s):  
Sandra Marcia Muxel ◽  
Ana Paula Freitas do Rosário ◽  
Cláudia Augusta Zago ◽  
Sheyla Inés Castillo-Méndez ◽  
Luiz Roberto Sardinha ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Blood Stage ◽  
Cd4 T Cell ◽  
Plasmodium Chabaudi ◽  
Two Phases

scholarly journals In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine

Gene Therapy ◽  
2007 ◽  
Vol 14 (20) ◽  
pp. 1481-1491
Author(s):  
S Cayeux ◽  
B Bukarica ◽  
C Buschow ◽  
J Charo ◽  
M Bunse ◽  
...  
Keyword(s):  
T Cell ◽  
Tumour Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cell Vaccine ◽  
Systemic Immunity

Low parasite specific T cell response in clinically immune individuals with low grade Plasmodium falciparum parasitaemia

1986 ◽  
Vol 80 (6) ◽  
pp. 1000-1001 ◽  
Author(s):  
T.G. Theander ◽  
I.C. Bygbjerg ◽  
L. Jacobsen ◽  
S. Jepsen ◽  
P.B. Larsen ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Low Grade

Epitope Analysis of Human T-Cell Response to MSP-1 of Plasmodium falciparum in Malaria-Nonexposed Individuals

1997 ◽  
Vol 114 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Nobuo Ohta ◽  
Kimiko Iwaki ◽  
Makoto Itoh ◽  
Jun Fu ◽  
Shigeko Nakashima ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Epitope Analysis ◽  
Human T Cell

scholarly journals A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys

2015 ◽  
Vol 17 (1) ◽  
pp. 130-139 ◽  
Author(s):  
Alexander D. Douglas ◽  
G. Christian Baldeviano ◽  
Carmen M. Lucas ◽  
Luis A. Lugo-Roman ◽  
Cécile Crosnier ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Infection ◽  
Blood Stage ◽  
Plasmodium Falciparum Infection

scholarly journals An Essential Role for C5aR Signaling in the Optimal Induction of a Malaria-Specific CD4+ T Cell Response by a Whole-Killed Blood-Stage Vaccine

2013 ◽  
Vol 191 (1) ◽  
pp. 178-186 ◽  
Author(s):  
Taiping Liu ◽  
Guilian Xu ◽  
Bo Guo ◽  
Yong Fu ◽  
Yuan Qiu ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Essential Role ◽  
T Cell Response ◽  
Blood Stage ◽  
Cd4 T Cell

scholarly journals The Th1 Immune Response to Plasmodium falciparum Circumsporozoite Protein Is Boosted by Adenovirus Vectors 35 and 26 with a Homologous Insert

2010 ◽  
Vol 17 (11) ◽  
pp. 1687-1694 ◽  
Author(s):  
Katarina Radošević ◽  
Ariane Rodriguez ◽  
Angelique A. C. Lemckert ◽  
Marjolein van der Meer ◽  
Gert Gillissen ◽  
...  
Keyword(s):  
Immune Response ◽  
Plasmodium Falciparum ◽  
T Cell ◽  
Cell Response ◽  
T Cell Responses ◽  
T Cell Response ◽  
Virus Surface ◽  
Cell Responses ◽  
Ifn Γ ◽  
Th1 Immune Response

ABSTRACT The most advanced malaria vaccine, RTS,S, is comprised of an adjuvant portion of the Plasmodium falciparum circumsporozoite (CS) protein fused to and admixed with the hepatitis B virus surface antigen. This vaccine confers short-term protection against malaria infection, with an efficacy of about 50%, and induces particularly B-cell and CD4+ T-cell responses. In the present study, we tested by the hypothesis that the Th1 immune response to CS protein, in particular the CD8+ T-cell response, which is needed for strong and lasting malaria immunity, is boosted to sustainable levels vectors adenovirus and 26 with an homologous insert 35 (Ad35.CS/Ad26.CS). In this study, we evaluated immune responses induced with vaccination regimens based on an adjuvant-containing, yeast-produced complete CS protein followed by two recombinant low-seroprevalence adenoviruses expressing P. falciparum CS antigen, Ad35.CS (subgroup B) and Ad26.CS (subgroup D). Our results show that (i) the yeast (Hansenula polymorpha)produced, adjuvanted full-length CS protein is highly potent in inducing high CS-specific humoral responses in mice but produces poor T-cell responses, (ii) the Ad35.CS vector boosts the gamma interferon-positive (IFN-γ+) CD8+ T-cell response induced by the CS protein immunization and shifts the immune response toward the Th1 type, and (iii) a three-component heterologous vaccination comprised of a CS protein prime followed by boosts with Ad35.CS and Ad26.CS elicits an even more robust and sustainable IFN-γ+ CD8+ T-cell response than one- or two-component regimens. The Ad35.CS/Ad26.CS combination boosted particularly the IFN-γ+ and tumor necrosis factor alpha-positive (TNF-α+) T cells, confirming the shift of the immune response from the Th2 type to the Th1 type. These results support the notion of first immunizations of infants with an adjuvanted CS protein vaccine, followed by a booster Ad35.CS/Ad26.CS vaccine at a later age, to induce lasting protection against malaria for which the Th1 response and immune memory is required.

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