Building tolerance by dismantling synapses: inhibitory receptor signaling in natural killer cells

2012 ◽  
Vol 251 (1) ◽  
pp. 143-153 ◽  
Author(s):  
Morgan Huse ◽  
S. Catherine Milanoski ◽  
Thushara P. Abeyweera
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Receptor Signaling ◽  
Inhibitory Receptor ◽  
Killer Cells

scholarly journals Increased frequency of human leukocyte antigen–E inhibitory receptor CD94/NKG2A–expressing peritoneal natural killer cells in patients with endometriosis

2008 ◽  
Vol 89 (5) ◽  
pp. 1490-1496 ◽  
Author(s):  
Ricciarda Galandrini ◽  
Maria Grazia Porpora ◽  
Antonella Stoppacciaro ◽  
Federica Micucci ◽  
Cristina Capuano ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Human Leukocyte Antigen ◽  
Natural Killer ◽  
Human Leukocyte ◽  
Inhibitory Receptor ◽  
Killer Cells ◽  
Leukocyte Antigen

scholarly journals Matched Sizes of Activating and Inhibitory Receptor/Ligand Pairs Are Required for Optimal Signal Integration by Human Natural Killer Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e15374 ◽  
Author(s):  
Karsten Köhler ◽  
Shiqiu Xiong ◽  
Joanna Brzostek ◽  
Maryam Mehrabi ◽  
Philipp Eissmann ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Signal Integration ◽  
Inhibitory Receptor ◽  
Receptor Ligand ◽  
Killer Cells ◽  
Human Natural Killer Cells ◽  
Optimal Signal

scholarly journals Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis

2002 ◽  
Vol 77 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Nagamasa Maeda ◽  
Chiaki Izumiya ◽  
Yorito Yamamoto ◽  
Hiroyoshi Oguri ◽  
Tomoaki Kusume ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Inhibitory Receptor ◽  
Pelvic Endometriosis ◽  
Killer Cells ◽  
Killer Inhibitory Receptor

scholarly journals Identification and Molecular Cloning of P75/Airm1, a Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells

1999 ◽  
Vol 190 (6) ◽  
pp. 793-802 ◽  
Author(s):  
Michela Falco ◽  
Roberto Biassoni ◽  
Cristina Bottino ◽  
Massimo Vitale ◽  
Simona Sivori ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Sequence Similarity ◽  
Tyrosine Phosphatase ◽  
Amino Acid Sequence Similarity ◽  
Inhibitory Receptor ◽  
Killer Cells ◽  
Human Natural Killer Cells ◽  
Src Homology ◽  
Src Homology 2 Domain

In this study, by the generation of a specific monoclonal antibody, we identified p75/AIRM1 (for adhesion inhibitory receptor molecule 1), a novel inhibitory receptor that is mostly confined to human natural killer cells. p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-1. The p75/AIRM1 gene is located on human chromosome 19 and encodes a novel member of the sialoadhesin family characterized by three immunoglobulin-like extracellular domains (one NH2-terminal V-type and two C2-type) and a classical immunoreceptor tyrosine–based inhibitory motif (ITIM) in the cytoplasmic portion. The highest amino acid sequence similarity has been found with the myeloid-specific CD33 molecule and the placental CD33L1 protein. Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid–dependent ligand recognition.

scholarly journals Inhibitory Receptor-Mediated Regulation of Natural Killer Cells

2014 ◽  
Vol 34 (6) ◽  
pp. 455-465 ◽  
Author(s):  
Elisenda Alari-Pahissa ◽  
Camille Grandclement ◽  
Beena Jeevan-Raj ◽  
Werner Held
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Inhibitory Receptor ◽  
Killer Cells
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