Regulation of EAE by spontaneously generated IL‐10 secreting regulatory T cells in HLA‐DR15/TCR.Ob1A12 double transgenic mice

Immunology ◽  
2021 ◽  
Author(s):  
Ester Leno‐Durán ◽  
Sze‐Ling Ng ◽  
Jack L. Strominger
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transgenic Mice ◽  
Double Transgenic Mice

Modulation of T-Cell Functions in KIR2DL3 (CD158b) Transgenic Mice

Blood ◽  
1999 ◽  
Vol 94 (7) ◽  
pp. 2396-2402 ◽  
Author(s):  
Anna Cambiaggi ◽  
Sylvie Darche ◽  
Sophie Guia ◽  
Philippe Kourilsky ◽  
Jean-Pierre Abastado ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Activation ◽  
Cell Activation ◽  
Killer Cell ◽  
In Vitro Proliferation ◽  
Cell Functions ◽  
Double Transgenic Mice

In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with KIR+ β and γδ T-cell clones showed that engagement of KIR molecules can extinguish T-cell activation signals induced via the CD3/T-cell receptor (TCR) complex. We analyzed the T-cell compartment in mice transgenic for KIR2DL3 (Tg-KIR2DL3), an inhibitory receptor for HLA-Cw3. As expected, mixed lymphocyte reaction and anti-CD3 monoclonal antibody (MoAb)-redirected cytotoxicity exerted by freshly isolated splenocytes can be inhibited by engagement of transgenic KIR2DL3 molecules. In contrast, antigen and anti-CD3 MoAb-induced cytotoxicity exerted by alloreactive cytotoxic T lymphocytes cannot be inhibited by KIR2DL3 engagement. In double transgenic mice, Tg-KIR2DL3 × Tg-HLA-Cw3, no alteration of thymic differentiation could be documented. Immunization of double transgenic mice with Hen egg white lysozime (HEL) or Pigeon Cytochrome-C (PCC) was indistinguishable from immunization of control mice, as judged by recall antigen-induced in vitro proliferation and TCR repertoire analysis. These results indicate that KIR effect on T cells varies upon cell activation stage and show unexpected complexity in the biological function of KIRs in vivo.

scholarly journals Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Elisabeth Zinser ◽  
Ronald Naumann ◽  
Andreas B. Wild ◽  
Julia Michalski ◽  
Andrea Deinzer ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transgenic Mice ◽  
Endogenous Expression

scholarly journals IL-2 Immunotoxin Therapy Modulates Tumor-Associated Regulatory T Cells and Leads to Lasting Immune-Mediated Rejection of Breast Cancers in neu-Transgenic Mice

2006 ◽  
Vol 177 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Keith L. Knutson ◽  
Yushe Dang ◽  
Hailing Lu ◽  
Jason Lukas ◽  
Bond Almand ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transgenic Mice ◽  
Breast Cancers ◽  
Immune Mediated

scholarly journals Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points

2011 ◽  
Vol 108 (6) ◽  
pp. 2420-2425 ◽  
Author(s):  
K. K. Dietze ◽  
G. Zelinskyy ◽  
K. Gibbert ◽  
S. Schimmer ◽  
S. Francois ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Transgenic Mice ◽  
Cd8 T Cells

Anti-LFA-1 Antibody Postpones T-cell Receptor Triggering While Preserving Generation of Regulatory T Cells in T-cell Receptor Anti-HY Transgenic Mice

2006 ◽  
Vol 82 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Seitetsu Go ◽  
Audrey Fleischmann ◽  
Olivier Lantz ◽  
C??lia Cretolle ◽  
Nicole Brousse ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Transgenic Mice ◽  
T Cell Receptor ◽  
Cell Receptor
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