scholarly journals Quantifying immunoregulation by autoantigen‐specific T‐regulatory type 1 cells in mice with simultaneous hepatic and extra‐hepatic autoimmune disorders

Immunology ◽  
2020 ◽  
Vol 161 (3) ◽  
pp. 209-229 ◽  
Author(s):  
Hassan Jamaleddine ◽  
Pere Santamaria ◽  
Anmar Khadra
Keyword(s):  
Autoimmune Disorders ◽  
Regulatory Type

scholarly journals APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Laurence Pellerin ◽  
Ping Chen ◽  
Silvia Gregori ◽  
Gabriela Hernandez-Hoyos ◽  
Rosa Bacchetta ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Regulatory Type

scholarly journals Cell therapy with human T regulatory type 1 cells in allogeneic transplantations

Immunotherapy ◽  
2011 ◽  
Vol 3 (4s) ◽  
pp. 27-27
Author(s):  
Rosa Bacchetta ◽  
Silvia Gregori ◽  
Barbarella Lucarelli ◽  
Maria Grazia Roncarolo
Keyword(s):  
Cell Therapy ◽  
Regulatory Type

Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment

2007 ◽  
Vol 56 (9) ◽  
pp. 1429-1442 ◽  
Author(s):  
Christoph Bergmann ◽  
Laura Strauss ◽  
Reinhard Zeidler ◽  
Stephan Lang ◽  
Theresa L. Whiteside
Keyword(s):  
Tumor Microenvironment ◽  
Regulatory Type

scholarly journals Antigen Microarrays for the Study of Autoimmune Diseases

2013 ◽  
Vol 59 (7) ◽  
pp. 1036-1044 ◽  
Author(s):  
Ada Yeste ◽  
Francisco J Quintana
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Disease Diagnosis ◽  
Autoimmune Disorders ◽  
Response To Therapy ◽  
Autoimmune Response ◽  
Molecular Pathways ◽  
Systemic Lupus

BACKGROUND The immune response involves the activation of heterogeneous populations of T cells and B cells that show different degrees of affinity and specificity for target antigens. Although several techniques have been developed to study the molecular pathways that control immunity, there is a need for high-throughput assays to monitor the specificity of the immune response. CONTENT Antigen microarrays provide a new tool to study the immune response. We reviewed the literature on antigen microarrays and their advantages and limitations, and we evaluated their use for the study of autoimmune diseases. Antigen arrays have been successfully used for several purposes in the investigation of autoimmune disorders: for disease diagnosis, to monitor disease progression and response to therapy, to discover mechanisms of pathogenesis, and to tailor antigen-specific therapies to the autoimmune response of individual patients. In this review we discuss the use of antigen microarrays for the study of 4 common autoimmune diseases and their animal models: type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. CONCLUSIONS Antigen microarrays constitute a new tool for the investigation of the immune response in autoimmune disorders and also in other conditions such as tumors and allergies. Once current limitations are overcome, antigen microarrays have the potential to revolutionize the investigation and management of autoimmune diseases.

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