scholarly journals Interleukin‐9 blockage reduces early hepatic granuloma formation and fibrosis during Schistosoma japonicum infection in mice

Immunology ◽  
2019 ◽  
Vol 158 (4) ◽  
pp. 296-303 ◽  
Author(s):  
Tingzheng Zhan ◽  
Huihui Ma ◽  
Suqin Jiang ◽  
Zirong Zhong ◽  
Xiaoli Wang ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Granuloma Formation ◽  
Hepatic Granuloma ◽  
Interleukin 9

scholarly journals Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1262 ◽  
Author(s):  
Wei Zhou ◽  
Yingying Yang ◽  
Congjin Mei ◽  
Panpan Dong ◽  
Shasha Mu ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Hepatic Fibrosis ◽  
Hepatic Stellate Cells ◽  
Th17 Cells ◽  
Worm Burden ◽  
Molecular Mechanisms ◽  
Stellate Cells ◽  
Granuloma Formation ◽  
Type I ◽  
Hepatic Granuloma

Background: Schistosomiasis is an immunopathogenic disease in which Th17 cells play vital roles. Hepatic granuloma formation and subsequent fibrosis are its main pathologic manifestations and the leading causes of hepatic cirrhosis, and effective therapeutic interventions are lacking. In this study, we explored the effects of fasudil, a selective RhoA–Rho-associated kinase (ROCK) inhibitor, on Th17 cells and the pathogenesis of schistosomiasis. Methods: Mice were infected with Schistosoma japonicum and treated with fasudil. The worm burden, hepatic granuloma formation, and fibrosis were evaluated. The roles of fasudil on Th17, Treg, and hepatic stellate cells were analyzed. Results: Fasudil therapy markedly reduced the granuloma size and collagen deposit in livers from mice infected with S. japonicum. However, fasudil therapy did not affect the worm burden in infected mice. The underlying cellular and molecular mechanisms were investigated. Fasudil suppressed the activation and induced the apoptosis of CD4+ T cells. Fasudil inhibited the differentiation and effector cytokine secretion of Th17 cells, whereas it upregulated Treg cells in vitro. It also restrained the in vivo interleukin (IL)-4 and IL-17 levels in infected mice. Fasudil directly induced the apoptosis of hepatic stellate cells and downregulated the expressions of hepatic fibrogenic genes, such as collagen type I (Col-I), Col-III, and transforming growth factor-1 (TGF-β1). These effects may contribute to its anti-pathogenic roles in schistosomiasis. Conclusions: Fasudil inhibits hepatic granuloma formation and fibrosis with downregulation of Th17 cells. Fasudil might serve as a novel therapeutic agent for hepatic fibrosis due to schistosome infections and perhaps other disorders.

Effect of IL-12 on granuloma formation induced by injected Schistosoma japonicum eggs

1997 ◽  
Vol 27 (7) ◽  
pp. 861-864 ◽  
Author(s):  
Jun-Qi Yang ◽  
Kachio Tasaka ◽  
Hideshi Yoshikawa ◽  
Cheng-Kuo Chuang ◽  
Masaru Minai ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Granuloma Formation

scholarly journals Erosive Arthritis and Hepatic Granuloma Formation Induced by Peptidoglycan Polysaccharide in Rats Is Aggravated by Prasugrel Treatment

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69093 ◽  
Author(s):  
Analia E. Garcia ◽  
Mario C. Rico ◽  
Elisabetta Liverani ◽  
Raul A. DeLa Cadena ◽  
Paul F. Bray ◽  
...  
Keyword(s):  
Granuloma Formation ◽  
Hepatic Granuloma ◽  
Erosive Arthritis

Characteristics of eosinophilic inclusions within Schistosoma japonicum eggs

Parasitology ◽  
1999 ◽  
Vol 118 (3) ◽  
pp. 269-274 ◽  
Author(s):  
M. HIRATA ◽  
T. NAKASHIMA ◽  
T. FUKUMA
Keyword(s):  
Schistosoma Japonicum ◽  
Granuloma Formation ◽  
Mouse Serum ◽  
Exact Nature ◽  
Factors Associated ◽  
Splenic Cells ◽  
Eosinophilic Inclusions ◽  
Egg Antigen

Although eosinophilic bar- or droplet-like inclusions are frequently detectable inside eggs deposited in the livers of Schistosoma japonicum-infected animals, little is known of their exact nature. In the livers of mice implanted with freshly laid eggs, inclusion-positive eggs were found in 28·7 and 46·2% of deposited eggs at 2 and 4 weeks, respectively, after implantation, but in 4·3% at 5 weeks when most of the eggs had already degenerated. When the extent of granuloma formation was investigated, granulomas around inclusion-positive eggs were smaller than those around negative eggs. Host factors associated with the formation of inclusion were sought using in vivo and in vitro studies. Following the administration of anti-egg antigen serum into egg-implanted mice, no increase in occurrence of inclusion-positive eggs was seen. In a co-culture of mature eggs with infected rabbit or mouse serum, inclusions were rarely found. In contrast, they were found in 17·9% of eggs in the presence of splenic cells. The present study is the first to show that there is decreased granuloma formation in the presence of eosinophilic inclusions inside eggs and our in vitro study suggests that host cell–egg interaction is responsible for the formation of inclusions.

The effects of T cell deficiency on the development of worms and granuloma formation in mice infected with Schistosoma japonicum

2008 ◽  
Vol 102 (6) ◽  
pp. 1129-1134 ◽  
Author(s):  
Yu-li Cheng ◽  
Wen-jian Song ◽  
Wen-qi Liu ◽  
Jia-hui Lei ◽  
Hong-mei Mo ◽  
...  
Keyword(s):  
T Cell ◽  
Schistosoma Japonicum ◽  
Granuloma Formation
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