scholarly journals Sialomucin CD 43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration

Immunology ◽  
2019 ◽  
Vol 157 (1) ◽  
pp. 52-69 ◽  
Author(s):  
Francisco E. Velázquez ◽  
Marina Anastasiou ◽  
Francisco J. Carrillo‐Salinas ◽  
Njabulo Ngwenyama ◽  
Ane M. Salvador ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Transendothelial Migration ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
T Helper ◽  
Intercellular Adhesion Molecule 1 ◽  
Helper Type

Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

Blood ◽  
2005 ◽  
Vol 105 (7) ◽  
pp. 2852-2861 ◽  
Author(s):  
Olga Barreiro ◽  
María Yáñez-Mó ◽  
Mónica Sala-Valdés ◽  
María Dolores Gutiérrez-López ◽  
Susana Ovalle ◽  
...  
Keyword(s):  
Adhesion Molecule ◽  
Leukocyte Adhesion ◽  
Transendothelial Migration ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Glutathione S Transferase ◽  
Large Extracellular Loop ◽  
And Migration ◽  
Cell Adhesion Molecule 1

AbstractTetraspanins associate with several transmembrane proteins forming microdomains involved in intercellular adhesion and migration. Here, we show that endothelial tetraspanins relocalize to the contact site with transmigrating leukocytes and associate laterally with both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Alteration of endothelial tetraspanin microdomains by CD9–large extracellular loop (LEL)–glutathione S–transferase (GST) peptides or CD9/CD151 siRNA oligonucleotides interfered with ICAM-1 and VCAM-1 function, preventing lymphocyte transendothelial migration and increasing lymphocyte detachment under shear flow. Heterotypic intercellular adhesion mediated by VCAM-1 or ICAM-1 was augmented when expressed exogenously in the appropriate tetraspanin environment. Therefore, tetraspanin microdomains have a crucial role in the proper adhesive function of ICAM-1 and VCAM-1 during leukocyte adhesion and transendothelial migration.

Control of islet intercellular adhesion molecule-1 expression by interferon-alpha and hypoxia

Diabetes ◽  
1996 ◽  
Vol 45 (10) ◽  
pp. 1336-1343 ◽  
Author(s):  
D. Chakrabarti ◽  
X. Huang ◽  
J. Beck ◽  
J. Henrich ◽  
N. McFarland ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1
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