scholarly journals Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer

Immunology ◽  
2018 ◽  
Vol 155 (2) ◽  
pp. 263-272 ◽  
Author(s):  
Rong Yang ◽  
Ting-ting Cai ◽  
Xiao-jun Wu ◽  
Yi-na Liu ◽  
Jia He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Expansion ◽  
Suppressor Cell ◽  
Pten Expression ◽  
Myeloid Suppressor Cell

Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion

2007 ◽  
Vol 7 (2) ◽  
pp. 140-151 ◽  
Author(s):  
James E. Talmadge ◽  
Keith C. Hood ◽  
Lori C. Zobel ◽  
Laura R. Shafer ◽  
Melissa Coles ◽  
...  
Keyword(s):  
Cell Expansion ◽  
Suppressor Cell ◽  
Cyclooxygenase 2 ◽  
Myeloid Suppressor Cell

scholarly journals Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor

2020 ◽  
Vol 123 (6) ◽  
pp. 955-964
Author(s):  
Kazuya Iwamoto ◽  
Hidekazu Takahashi ◽  
Daisuke Okuzaki ◽  
Hideo Osawa ◽  
Takayuki Ogino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Prostaglandin E2 Receptor

Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart Transplantation

2018 ◽  
Vol 102 ◽  
pp. S599
Author(s):  
Keiichi Fujimoto ◽  
Koichiro Uchida ◽  
Enzhi Yin ◽  
mio mejima ◽  
Kazuyoshi Takeda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Heart Transplantation ◽  
Graft Survival ◽  
Suppressor Cell ◽  
Myeloid Suppressor Cell

842 Cancer-Derived Myofibroblasts Promote Tumor Initiating Cell Expansion in Colorectal Cancer

2009 ◽  
Vol 136 (5) ◽  
pp. A-128
Author(s):  
Randy C. Mifflin ◽  
Iryna V. Pinchuk ◽  
Jamal I. Saada ◽  
Sahil Mittal ◽  
Suimin Qiu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Expansion ◽  
Tumor Initiating Cell

miR-203 Regulates Proliferation and Apoptosis of Colorectal Cancer Cells Through Targeting DJ-1

2020 ◽  
Vol 10 (3) ◽  
pp. 365-370
Author(s):  
Qiupeng Du ◽  
Na Du ◽  
Chenchen Zhu ◽  
Qingqing Shang ◽  
Haiyan Mao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Pten Expression ◽  
Proliferation And Apoptosis ◽  
Colorectal Cancer Cells ◽  
Colorectal Cell ◽  
Sw480 Cells

Objective: To assess whether miR-203 regulates DJ-1 expression, affects colorectal cancer cells through PTEN-PI3K/AKT signaling. Methods: Colorectal cancer (CRC) tissues and adjacent tissues were collected followed by analysis of the level of miR-203, DJ-1 and PTEN. miR-203 and DJ-1 level was measured in HCT116, SW480 and normal colorectal cell NCM460. miR-203 mimic or miR-NC was transfected into HCT116 or SW480 cells followed by measuring the level of miR-203, DJ-1, PTEN, p-AKT as well as cell apoptosis and proliferation. Results: Compared with tumor adjacent tissues, tumor tissues showed significantly lower level of miR-203 and PTEN, and higher level of DJ-1. There is a targeted relationship between miR-203 and DJ-1. Compared with NCM460 cell, HCT116 and SW480 cells displayed significantly lower miR-203 level and higher DJ-1 expression. miR-203 mimic significantly reduced DJ-1 and p-AKT level, increased PTEN expression, cell apoptosis and inhibited cell proliferation. Conclusion: Lower miR-203 and higher DJ-1 level is found in CRC patients. Upregulation of miR-203 inhibits DJ-1 expression, increases PTEN expression, impairs PI3K/AKT signaling, inhibits CRC cell proliferation and promotes apoptosis.

scholarly journals Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4+ T cells from patients with GI malignancy

2011 ◽  
Vol 60 (9) ◽  
pp. 1269-1279 ◽  
Author(s):  
Bethany L. Mundy-Bosse ◽  
Gregory S. Young ◽  
Todd Bauer ◽  
Elaine Binkley ◽  
Mark Bloomston ◽  
...  
Keyword(s):  
T Cells ◽  
Interferon Alpha ◽  
Cd4 T Cells ◽  
Suppressor Cell ◽  
Myeloid Suppressor Cell
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