scholarly journals EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances γδT-cell-mediated cytotoxicity via TCR and NKG2D

Immunology ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 673-682 ◽  
Author(s):  
Yu-mei Dai ◽  
Hai-ying Liu ◽  
Yun-feng Liu ◽  
Yuan Zhang ◽  
Wei He
Keyword(s):  
B Lymphocytes ◽  
Γδt Cell ◽  
Ebv Transformation

scholarly journals Improved efficiency of EBV transformation of B-lymphocytes

2004 ◽  
Vol 37 (6) ◽  
pp. 443-444 ◽  
Author(s):  
Helen Bass ◽  
Christopher Darke
Keyword(s):  
B Lymphocytes ◽  
Ebv Transformation

scholarly journals Interferon Regulatory Factor 4 Is Involved in Epstein-Barr Virus-Mediated Transformation of Human B Lymphocytes

2008 ◽  
Vol 82 (13) ◽  
pp. 6251-6258 ◽  
Author(s):  
Dongsheng Xu ◽  
Lingjun Zhao ◽  
Luis Del Valle ◽  
Judith Miklossy ◽  
Luwen Zhang
Keyword(s):  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Barr Virus ◽  
Ebv Transformation ◽  
Epstein Barr ◽  
Cns Lymphomas ◽  
Interferon Regulatory Factor 4

ABSTRACT Epstein-Barr virus (EBV) infection is associated with many human malignancies. In vitro, EBV transforms primary B lymphocytes into continuously growing lymphoblastoid cell lines. EBV latent membrane protein 1 (LMP-1) is required for EBV transformation processes. Interferon regulatory factor 4 (IRF-4) is a transcription factor and has oncogenic potential. We find that high levels of IRF-4 are associated with EBV transformation of human primary B cells in vitro and with EBV type III latency in which LMP-1 is expressed. We show that EBV LMP-1 stimulates IRF-4 expression in B lymphocytes. The stimulation of IRF-4 by LMP-1 requires signaling from LMP-1 and involves cellular NF-κB. The growth of EBV-transformed cells is inhibited when IRF-4 is specifically down-regulated. We further demonstrate that IRF-4 knockdown cells have lower proliferation but higher apoptotic rates than control cells. Finally, IRF-4 is expressed in significant numbers of specimens of primary central nervous system (CNS) lymphomas (12/27 [44.4%]), an EBV-associated malignancy. The association between the expression levels of LMP-1 and IRF-4 is statistically significant (P = 0.011) in these CNS lymphomas. Our data suggest that IRF-4 may be a critical factor in EBV transformation and a useful target in the therapy of EBV-mediated neoplasia.

Altered Fine Structure of B Lymphocytes Correlated with Defective Terminal Differentiation

1973 ◽  
Vol 31 ◽  
pp. 386-387
Author(s):  
Dale E. Bockman ◽  
L. Y. Frank Wu ◽  
Alexander R. Lawton ◽  
Max D. Cooper
Keyword(s):  
Immune Deficiency ◽  
B Lymphocytes ◽  
Plasma Cells ◽  
Present Report ◽  
Specific Antigen ◽  
Terminal Differentiation ◽  
Second Stage ◽  
Two Stages ◽  
Deficiency Diseases ◽  
Cell Line Generation

B-lymphocytes normally synthesize small amounts of immunoglobulin, some of which is incorporated into the cell membrane where it serves as receptor of antigen. These cells, on contact with specific antigen, proliferate and differentiate to plasma cells which synthesize and secrete large quantities of immunoglobulin. The two stages of differentiation of this cell line (generation of B-lymphocytes and antigen-driven maturation to plasma cells) are clearly separable during ontogeny and in some immune deficiency diseases. The present report describes morphologic aberrations of B-lymphocytes in two diseases in which second stage differentiation is defective.

Expression of CD81, am ligand for hepatitis C virus (HCV) is increased on CD5+ B-lymphocytes but may not be the receptor for internalisation of HCV

2001 ◽  
Vol 120 (5) ◽  
pp. A552-A552
Author(s):  
M CURRY ◽  
T DEIGNAN ◽  
P COSTELLO ◽  
L GOLDENMASON ◽  
M DUFFY ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Lymphocytes

Author response for "Autoreactive B‐Lymphocytes in SLE and RA patients: Isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads"

2019 ◽  
Author(s):  
Raquel la Varga‐Martínez ◽  
Beatriz Rodríguez‐Bayona ◽  
Antonio Campos‐Caro ◽  
Gustavo A Añez ◽  
Fermín Medina‐Varo
Keyword(s):  
B Lymphocytes ◽  
Author Response

Relationship among T- and B-lymphocytes of the peripheral blood and thyroid tissue in patients with Graves' disease

2019 ◽  
Author(s):  
Margarita A Dudina ◽  
Andrey A Savchenko ◽  
Sergey A Dogadin ◽  
Alexandr G Borisov ◽  
Igor V Kudryavcev ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Peripheral Blood ◽  
Thyroid Tissue ◽  
T And B Lymphocytes ◽  
Graves Disease
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