scholarly journals Mesenteric lymph node CD11b− CD103+ PD-L1High dendritic cells highly induce regulatory T cells

Immunology ◽  
2017 ◽  
Vol 152 (1) ◽  
pp. 52-64 ◽  
Author(s):  
Aya Shiokawa ◽  
Ryutaro Kotaki ◽  
Tomohiro Takano ◽  
Haruyo Nakajima-Adachi ◽  
Satoshi Hachimura
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Regulatory T Cells ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph

scholarly journals Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance

Blood ◽  
2010 ◽  
Vol 116 (13) ◽  
pp. 2266-2276 ◽  
Author(s):  
Tomohiro Fukaya ◽  
Hideaki Takagi ◽  
Yumiko Sato ◽  
Kaori Sato ◽  
Kawori Eizumi ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Regulatory T Cells ◽  
Mesenteric Lymph Node ◽  
Oral Tolerance ◽  
Family Members ◽  
T Cell Response ◽  
Mesenteric Lymph ◽  
B7 Family

Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to fed antigens. However, the molecular mechanism mediating oral tolerance remains unclear. In this study, we examined the role of the B7 family members of costimulatory molecules in the establishment of oral tolerance. Deficiencies of B7-H1 and B7-DC abrogated the oral tolerance, accompanied by enhanced antigen-specific CD4+ T-cell response and IgG1 production. Mesenteric lymph node (MLN) dendritic cells (DCs) displayed higher levels of B7-H1 and B7-DC than systemic DCs, whereas they showed similar levels of CD80, CD86, and B7-H2. MLN DCs enhanced the antigen-specific generation of CD4+Foxp3+ inducible regulatory T cells (iTregs) from CD4+Foxp3− T cells rather than CD4+ effector T cells (Teff) relative to systemic DCs, owing to the dominant expression of B7-H1 and B7-DC. Furthermore, the antigen-specific conversion of CD4+Foxp3− T cells into CD4+Foxp3+ iTregs occurred in MLNs greater than in peripheral organs during oral tolerance under steady-state conditions, and such conversion required B7-H1 and B7-DC more than other B7 family members, whereas it was severely impaired under inflammatory conditions. In conclusion, our findings suggest that B7-H1 and B7-DC expressed on MLN DCs are essential for establishing oral tolerance through the de novo generation of antigen-specific CD4+Foxp3+ iTregs.

scholarly journals Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells

2017 ◽  
Vol 47 (12) ◽  
pp. 2142-2152 ◽  
Author(s):  
Maria Pasztoi ◽  
Joern Pezoldt ◽  
Michael Beckstette ◽  
Christoph Lipps ◽  
Dagmar Wirth ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Regulatory T Cells ◽  
Extracellular Vesicles ◽  
Mesenteric Lymph Node ◽  
Stromal Cell ◽  
De Novo ◽  
Mesenteric Lymph

scholarly journals Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells

2008 ◽  
Vol 180 (10) ◽  
pp. 6501-6507 ◽  
Author(s):  
Raul Elgueta ◽  
Fernando E. Sepulveda ◽  
Felipe Vilches ◽  
Leonardo Vargas ◽  
J. Rodrigo Mora ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Cd4 T Cells ◽  
Mesenteric Lymph

scholarly journals IFN-γ Secreted by CD103+Dendritic Cells Leads to IgG Generation in the Mesenteric Lymph Node in the Absence of Vitamin A

2011 ◽  
Vol 186 (12) ◽  
pp. 6999-7005 ◽  
Author(s):  
Jae-Hoon Chang ◽  
Hye-Ran Cha ◽  
Sun-Young Chang ◽  
Hyun-Jeong Ko ◽  
Sang-Uk Seo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Vitamin A ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph ◽  
Ifn Γ
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