scholarly journals Phenotypic characterization of regulatory T cells from antiretroviral-naive HIV-1-infected people

Immunology ◽  
2017 ◽  
Vol 151 (4) ◽  
pp. 405-416 ◽  
Author(s):  
Georgia N. Ambada ◽  
Claudine E. Ntsama ◽  
Nadesh N. Nji ◽  
Loveline N. Ngu ◽  
Carole N. Sake ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Phenotypic Characterization ◽  
Infected People ◽  
Hiv 1

scholarly journals Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection

2013 ◽  
Vol 9 (1) ◽  
pp. e1003140 ◽  
Author(s):  
Chun Li ◽  
Ilona Toth ◽  
Julian Schulze zur Wiesch ◽  
Florencia Pereyra ◽  
Jennifer Rychert ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Functional Characterization ◽  
Hiv 1

scholarly journals Phenotypic Characterization of HIV-Specific CD8+ T Cells during Early and Chronic Infant HIV-1 Infection

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e20375 ◽  
Author(s):  
Jennifer A. Slyker ◽  
Grace C. John-Stewart ◽  
Tao Dong ◽  
Barbara Lohman-Payne ◽  
Marie Reilly ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Phenotypic Characterization ◽  
Hiv 1

Phenotypic characterization of regulatory T cells populations in maternal blood, cord blood and placenta from diabetic mothers

2017 ◽  
Vol 32 (7) ◽  
pp. 1098-1104 ◽  
Author(s):  
Adriele A. Queiroz ◽  
Eduardo L. França ◽  
Cristiane C. P. Hara ◽  
Mariana S. Honorio ◽  
Danny L. G. Fagundes ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cord Blood ◽  
Maternal Blood ◽  
Phenotypic Characterization ◽  
Diabetic Mothers

scholarly journals Functional and Phenotypic Characterization of CD57+CD4+T Cells and Their Association with HIV-1-Induced T Cell Dysfunction

2005 ◽  
Vol 175 (12) ◽  
pp. 8415-8423 ◽  
Author(s):  
Brent E. Palmer ◽  
Naomi Blyveis ◽  
Andrew P. Fontenot ◽  
Cara C. Wilson
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Phenotypic Characterization ◽  
Cell Dysfunction ◽  
T Cell Dysfunction ◽  
Hiv 1

scholarly journals Phenotypic characterization of regulatory T cells in the human decidua

2004 ◽  
Vol 136 (2) ◽  
pp. 373-378 ◽  
Author(s):  
J. HEIKKINEN ◽  
M. MOTTONEN ◽  
A. ALANEN ◽  
O. LASSILA
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Phenotypic Characterization ◽  
Human Decidua

scholarly journals Proteomic characterization of signal transduction by P2X7 in regulatory T cells (609.8)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Gabriella Tedeschi ◽  
Elisa Maffioli ◽  
Armando Negri ◽  
Andrea Romagnani ◽  
Fabio Grassi
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Regulatory T Cells

scholarly journals Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

2017 ◽  
Author(s):  
Sean Matthew McCauley ◽  
Kyusik Kim ◽  
Anetta Nowosielska ◽  
Ann Dauphin ◽  
Leonid Yurkovetskiy ◽  
...  
Keyword(s):  
T Cells ◽  
Antiviral Therapy ◽  
Antiviral Drug ◽  
Cell Types ◽  
Innate Immune ◽  
Type I ◽  
Infected People ◽  
Innate Immune Signaling ◽  
Post Transcriptional Regulation ◽  
Hiv 1

ABSTRACTHIV-1-infected people who take drugs that suppress viremia to undetectable levels are protected from developing AIDS. Nonetheless, these individuals have chronic inflammation associated with heightened risk of cardiovascular pathology. HIV-1 establishes proviruses in long-lived CD4+memory T cells, and perhaps other cell types, that preclude elimination of the virus even after years of continuous antiviral therapy. Though the majority of proviruses that persist during antiviral therapy are defective for production of infectious virions, many are expressed, raising the possibility that the HIV-1provirus or its transcripts contribute to ongoing inflammation. Here we found that the HIV-1 provirus activated innate immune signaling in isolated dendritic cells, macrophages, and CD4+T cells. Immune activation required transcription from the HIV-1 provirus and expression of CRM1-dependent, Rev-dependent, RRE-containing, unspliced HIV-1 RNA. Ifrevwas providedin trans, all HIV-1 coding sequences were dispensable for activation except thosecis-acting sequences required for replication or splicing. These results indicate that the complex, post-transcriptional regulation intrinsic to HIV-1 RNA is detected by the innate immune system as a danger signal, and that drugs which disrupt HIV-1 transcription or HIV-1 RNA metabolism would add qualitative benefit to current antiviral drug regimens.

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