scholarly journals Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions

Immunology ◽  
2017 ◽  
Vol 151 (3) ◽  
pp. 304-313 ◽  
Author(s):  
Letícia de Aquino Penteado ◽  
Naiara Naiana Dejani ◽  
Felipe Fortino Verdan ◽  
Allan Botinhon Orlando ◽  
Victoria Eugenia Niño ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
And Migration ◽  
Distinctive Role

scholarly journals Controls for Lung Dendritic Cell Maturation and Migration during Respiratory Viral Infection

2007 ◽  
Vol 179 (3) ◽  
pp. 1438-1448 ◽  
Author(s):  
Mitchell H. Grayson ◽  
Madeleine S. Ramos ◽  
Michelle M. Rohlfing ◽  
Robert Kitchens ◽  
Howard D. Wang ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Viral Infection ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Respiratory Viral Infection ◽  
And Migration

CD40 Ligand-Dependent Maturation of Human Monocyte-Derived Dendritic Cells by Activated Platelets

2003 ◽  
Vol 16 (3) ◽  
pp. 225-231 ◽  
Author(s):  
N.C. Kaneider ◽  
A. Kaser ◽  
H. Tilg ◽  
G. Ricevuti ◽  
C.J. Wiedermann
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Thrombus Formation ◽  
Cd40 Ligand ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Monocyte Migration ◽  
Activated Platelets

Atherosclerosis is defined as an inflammatory immunological disease that is triggered by platelet activation, endothelial injury and consequent innate and adaptive immune processes. Dendritic cells are critical for the cell-mediated arm of the immune response as they activate naïve T cells after maturation. Platelets play a crucial role in thrombus formation in the injured vessel walls. We investigated the role of resting and thrombin-activated platelets in dendritic cell maturation in vitro using platelets and monocyte-derived dendritic cells from healthy donors. Resting platelet supernatants did not affect maturation, whereas supernatants from thrombin-activated platelets induced dendritic cell maturation as demonstrated by FACS analysis of HLA-DR expression. This effect was inhibited by anti CD40 ligand antibody, but not by aspirin pretreatment of platelets. Supernatants of platelet-dendritic cell co-cultures induced augmented monocyte migration when platelets were activated by thrombin, again reversible by blocking CD40 ligand. These data show that activated platelets trigger dendritic cell maturation independent of cyclooxygenase-derived arachidonic acid metabolites by mechanisms involving CD40 ligand, which is also involved in monocyte chemotactic mediator release from platelets and dendritic cells. The results of this study suggest a role of CD40 ligand from activated platelets in connecting innate and adaptive immunity.

scholarly journals Central Role of MyD88-Dependent Dendritic Cell Maturation and Proinflammatory Cytokine Production to ControlBrucella abortusInfection

2008 ◽  
Vol 180 (2) ◽  
pp. 1080-1087 ◽  
Author(s):  
Gilson Costa Macedo ◽  
Diogo Matos Magnani ◽  
Natalia Barbosa Carvalho ◽  
Oscar Bruna-Romero ◽  
Ricardo T. Gazzinelli ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Proinflammatory Cytokine ◽  
Cytokine Production ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Proinflammatory Cytokine Production

Heme Oxygenase-1 Ameliorates Ischemia/Reperfusion Injury by Targeting Dendritic Cell Maturation and Migration

2007 ◽  
Vol 9 (12) ◽  
pp. 2049-2064 ◽  
Author(s):  
Katja Kotsch ◽  
Paulo N.A. Martins ◽  
Roman Klemz ◽  
Uwe Janssen ◽  
Bernhard Gerstmayer ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Heme Oxygenase 1 ◽  
And Migration

scholarly journals Role of natural interferon-producing cells and T lymphocytes in porcine monocyte-derived dendritic cell maturation

Immunology ◽  
2006 ◽  
Vol 118 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Laurence Guzylack-Piriou ◽  
Sytse Piersma ◽  
Kenneth McCullough ◽  
Artur Summerfield
Keyword(s):  
Dendritic Cell ◽  
T Lymphocytes ◽  
Dendritic Cell Maturation ◽  
Cell Maturation
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