scholarly journals NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model

Immunology ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. 374-385 ◽  
Author(s):  
João Antônio Chaves de Souza ◽  
Sabrina Cruz Tfaile Frasnelli ◽  
Fabiana de Almeida Curylofo-Zotti ◽  
Mário Julio Ávila-Campos ◽  
Luis Carlos Spolidório ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Periodontal Disease ◽  
Disease Model ◽  
Microbe Interactions ◽  
Host Microbe Interactions

scholarly journals Role of NOD2 and RIP2 in host–microbe interactions with Gram-negative bacteria: insights from the periodontal disease model

2016 ◽  
Vol 22 (8) ◽  
pp. 598-611 ◽  
Author(s):  
Joao AC Souza ◽  
Marcell C Medeiros ◽  
Fernanda RG Rocha ◽  
Sabrina G de Aquino ◽  
Mario J Ávila-Campos ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Osteoclast Differentiation ◽  
Disease Model ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Macrophage Response ◽  
Chronic Inflammatory Condition ◽  
Host Microbe Interactions

NOD2 is a member of the NLR family of proteins that participate in the activation of the innate immune response. RIP2 is a downstream kinase activated by both NOD1 and NOD2. There is scarcity of information regarding the relevance of NOD2 in periodontitis, a chronic inflammatory condition characterized by inflammatory bone resorption. We used NOD2-KO and RIP2-KO mice in a model of microbial-induced periodontitis. Heat-killed Aggregatibacter actinomycetemcomitans was injected in the gingival tissues three times/wk for 4 wk. Bone resorption was assessed by μCT analysis; osteoclasts were identified by immunohistochemical staining for TRAP and inflammation was assessed using a severity score system in H/E-stained sections. In vitro studies using primary macrophages assessed the response macrophages using qPCR-based array and multi-ligand ELISA. Bone resorption and osteoclastogenesis were significantly reduced in NOD2-KO mice. Severity of inflammation was not affected. qPCR-focused arrays and multi-ligand ELISA showed that expression of pro-inflammatory mediators was reduced in NOD2- and RIP2-deficient cells. RANKL-induced osteoclastogenesis was impaired in NOD2- and RIP2-deficient macrophages. We conclude that NOD2 is important for osteoclast differentiation and inflammatory bone resorption in vivo and also for the macrophage response to Gram-negative bacteria.

Photodynamic Therapy Reduces Bone Resorption and Decreases Inflammatory Response in an Experimental Rat Periodontal Disease Model

2011 ◽  
Vol 29 (11) ◽  
pp. 735-740 ◽  
Author(s):  
Alexandre S. Carvalho ◽  
Marcelo H. Napimoga ◽  
Jozafá Coelho-Campos ◽  
Vilmar J. Silva-Filho ◽  
Geraldo Thedei
Keyword(s):  
Photodynamic Therapy ◽  
Bone Resorption ◽  
Inflammatory Response ◽  
Periodontal Disease ◽  
Disease Model

Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model

2018 ◽  
Vol 89 (4) ◽  
pp. 466-475 ◽  
Author(s):  
Vinícius de Paiva Gonçalves ◽  
Adriana Alicia C. Ortega ◽  
João Paulo Steffens ◽  
Denise Madalena Palomari Spolidorio ◽  
Carlos Rossa ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Periodontal Disease ◽  
Disease Model

Exploring Host-Microbe Interactions in Hydra

2009 ◽  
Vol 4 (10) ◽  
pp. 457-462 ◽  
Author(s):  
Sebastian Fraune ◽  
Thomas C. G. Bosch ◽  
René Augustin
Keyword(s):  
Microbe Interactions ◽  
Host Microbe Interactions

Pharmacology of T2R Mediated Host–Microbe Interactions

2021 ◽  
Author(s):  
Manoj Reddy Medapati ◽  
Anjali Y. Bhagirath ◽  
Nisha Singh ◽  
Prashen Chelikani
Keyword(s):  
Microbe Interactions ◽  
Host Microbe Interactions
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