scholarly journals Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors

Immunology ◽  
2014 ◽  
Vol 143 (4) ◽  
pp. 640-650 ◽  
Author(s):  
Alan D. Guerrero ◽  
Matthew B. Dong ◽  
Yongge Zhao ◽  
Annie Lau-Kilby ◽  
Kristin V. Tarbell
Keyword(s):  
Dendritic Cell ◽  
Interleukin 2 ◽  
Cell Development ◽  
Macrophage Precursors

scholarly journals Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer

2019 ◽  
Vol 110 ◽  
pp. 24-39 ◽  
Author(s):  
Taylor T. Chrisikos ◽  
Yifan Zhou ◽  
Natalie Slone ◽  
Rachel Babcock ◽  
Stephanie S. Watowich ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Development ◽  
Molecular Regulation ◽  
And Function

Transcriptional profiling identifies Id2 function in dendritic cell development

10.1038/ni903 ◽  
2003 ◽  
Vol 4 (4) ◽  
pp. 380-386 ◽  
Author(s):  
Christine Hacker ◽  
Ralf D. Kirsch ◽  
Xin-Sheng Ju ◽  
Thomas Hieronymus ◽  
Tatjana C. Gust ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Transcriptional Profiling ◽  
Cell Development

Loss of Function of the Homeobox Gene Hoxa-9 Perturbs Early T-Cell Development and Induces Apoptosis in Primitive Thymocytes

Blood ◽  
1998 ◽  
Vol 92 (2) ◽  
pp. 383-393 ◽  
Author(s):  
David J. Izon ◽  
Sofia Rozenfeld ◽  
Stephen T. Fong ◽  
László Kömüves ◽  
Corey Largman ◽  
...  
Keyword(s):  
T Cell ◽  
Hox Genes ◽  
Apoptotic Cell ◽  
T Cell Development ◽  
Interleukin 2 ◽  
Homeobox Gene ◽  
Cell Receptor ◽  
Cell Development ◽  
Loss Of Function ◽  
Double Positive

Abstract Hox homeobox genes play a crucial role in specifying the embryonic body pattern. However, a role for Hox genes in T-cell development has not been explored. The Hoxa-9 gene is expressed in normal adult and fetal thymuses. Fetal thymuses of mice homozygous for an interruption of the Hoxa-9 gene are one eighth normal size and have a 25-fold decrease in the number of primitive thymocytes expressing the interleukin-2 receptor (IL-2R, CD25). Progression to the double positive (CD4+CD8+) stage is dramatically retarded in fetal thymic organ cultures. This aberrant development is associated with decreased amounts of intracellular CD3 and T-cell receptor β (TCRβ) and reduced surface expression of IL-7R and E-cadherin. Mutant thymocytes show a significant increase in apoptotic cell death and premature downregulation of bcl-2 expression. A similar phenotype is seen in primitive thymocytes from adult Hoxa-9−/− mice and from mice transplanted with Hoxa-9−/−marrow. Hoxa-9 appears to play a previously unsuspected role in T-cell ontogeny by modulating cell survival of early thymocytes and by regulating their subsequent differentiation.

scholarly journals Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 ◽  
Vol 201 (5) ◽  
pp. 769-777 ◽  
Author(s):  
Allison L. Bayer ◽  
Aixin Yu ◽  
Dennis Adeegbe ◽  
Thomas R. Malek
Keyword(s):  
Treg Cell ◽  
Interleukin 2 ◽  
Treg Cells ◽  
Cell Development ◽  
Wild Type ◽  
T Regulatory Cell ◽  
Neonatal Mice ◽  
Early Developmental ◽  
Normal Neonates

Although many aspects of CD4+CD25+ T regulatory (Treg) cell development remain largely unknown, signaling through the IL-2R represents one feature for the production of Treg cells. Therefore, the present study was undertaken to further define early developmental steps in the production of Treg cells, including a more precise view on the role of interleukin (IL)-2 in this process. After adoptive transfer of wild-type Treg cells into neonatal IL-2Rβ−/− mice, only a small fraction of donor Treg cells selectively seeded the lymph node (LN). These donor Treg cells underwent rapid and extensive IL-2–dependent proliferation, followed by subsequent trafficking to the spleen. Thus, IL-2 is essential for Treg cell proliferation in neonatal LN. The number and distribution of Treg cells in the periphery of normal neonatal mice closely paralleled that seen for IL-2Rβ−/− mice that received Treg cells. However, for normal neonates, blockade of IL-2 decreased Treg cells in both the thymus and LN. Therefore, two steps of Treg cell development depend upon IL-2 in neonatal mice, thymus production, and subsequent expansion in the LN.

scholarly journals Protease-Activated Receptor-2 Signaling Triggers Dendritic Cell Development

2003 ◽  
Vol 162 (6) ◽  
pp. 1817-1822 ◽  
Author(s):  
Ryan C. Fields ◽  
Jonathan G. Schoenecker ◽  
Justin P. Hart ◽  
Maureane R. Hoffman ◽  
Salvatore V. Pizzo ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Development ◽  
Protease Activated Receptor 2
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