scholarly journals P44: SPECIFIC IGE TO GALACTOSE-ALPHA-1,3-GALACTOSE (ALPHA-GAL) DOES NOT ADD TO THE DIAGNOSIS OF MAMMALIAN MEAT ALLERGY IN A TICK-ENDEMIC POPULATION

2017 ◽  
Vol 47 ◽  
pp. 18-18
Author(s):  
J Li ◽  
RB Fulton ◽  
J Yun ◽  
SL Fernando
Keyword(s):  
Specific Ige ◽  
Meat Allergy ◽  
Endemic Population ◽  
Mammalian Meat

Specific-IgE to galactose-α-1,3-galactose (alpha-gal) has limited utility in diagnosing meat allergy in a tick-endemic population

2018 ◽  
Vol 121 (4) ◽  
pp. 509-511 ◽  
Author(s):  
Jamma Li ◽  
Richard B. Fulton ◽  
Rachel O'Connell ◽  
Helena S. Jang ◽  
Suran L. Fernando
Keyword(s):  
Specific Ige ◽  
Meat Allergy ◽  
Endemic Population

scholarly journals Mammalian Meat Allergy Accompanied by Venom Allergy: A Review of 12 Cases

2019 ◽  
Author(s):  
Ali Kutlu ◽  
Derya Unal
Keyword(s):  
Black Sea ◽  
Specific Ige ◽  
The Black Sea ◽  
Venom Allergy ◽  
Black Sea Region ◽  
Meat Allergy ◽  
Prick Test ◽  
Increased Risk ◽  
History Of ◽  
Mammalian Meat

There has recently been an increase in mammalian meat allergy (MMA) in the Black Sea Region of Turkey. It has been associated with the expansion of tick populations.Tick bites appear to result in sensitization to the carbohydrate allergen galactose-alpha–1, 3-galactose, which is present in many types of mammalian meats. In this study, we have emphasized that  Ixodes ricinus named tick type which is implicated in meat allergy, is found in domestic animals of Black Sea Region of Turkey. A new concept has been recently raized; suggesting that having an alpha-gal allergy is associated with an increased risk of sensitization to multiple venom spesific immunoglobulin (Ig) E. Our aim is to evaluate the clinical characteristics of adult patients with MMA and its relationship with insect sting reactions in Turkey. Patients referring to the allergy outpatient clinic with possible MMA were interviewed regarding reactions to a stinging insect. Demographic features and detailed histories of the patients were recorded. Skin prick test (SPT) with commercial beef extract and venom allergens, as well as prick to prick tests with raw beef and cooked beef were performed. Serum total IgE and beef meat specific IgE were measured. Of 50 interviewed patients, 12 patients (4 male [33,3%] and 8 female [66,6%]) had a history of venom hypersensitivity reaction. The mean age was 36.50±13.35 years (range:18–61). History of other allergic diseases was present in 8 (66.6%) patients. Both venom and meat allergy were confirmed with SPT or prick to prick tests in these 12 patients. Among these patients sensitization to honey bee venom was more frequent (83%). MMA and venom allergy are influenced by the same environmental exposures. We believe that there may be shared immunologic factors and similar antigens; making venom allergic patients more susceptible to MMA.

scholarly journals Could chiggers be contributing to the prevalence of galactose-alpha-1,3-galactose sensitization and mammalian meat allergy?

2019 ◽  
Vol 7 (2) ◽  
pp. 664-666 ◽  
Author(s):  
Lindsey P. Stoltz ◽  
Leslie M. Cristiano ◽  
Ashley P.G. Dowling ◽  
Jeffrey M. Wilson ◽  
Thomas A.E. Platts-Mills ◽  
...  
Keyword(s):  
Meat Allergy ◽  
Mammalian Meat

scholarly journals Tick Bites Induce Anti-α-Gal Antibodies in Dogs

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 114 ◽  
Author(s):  
Adnan Hodžić ◽  
Lourdes Mateos-Hernández ◽  
Michael Leschnik ◽  
Pilar Alberdi ◽  
Ryan Rego ◽  
...  
Keyword(s):  
Enzyme Linked Immunosorbent Assay ◽  
Tick Bites ◽  
Gene Encoding ◽  
Meat Allergy ◽  
Organ Rejection ◽  
Specific Igg ◽  
Functional Inactivation ◽  
Underlying Mechanisms ◽  
Mammalian Meat ◽  
Pathogenic Agents

Due to the functional inactivation of the gene encoding for the enzyme that is involved in the oligosaccharide galactose-α-1,3-galactose (α-Gal) synthesis, humans and Old-World primates are able to produce a large amount of antibodies against the glycan epitope. Apart from being involved in the hyperacute organ rejection in humans, anti-α-Gal antibodies have shown a protective effect against some pathogenic agents and an implication in the recently recognized tick-induced mammalian meat allergy. Conversely, non-primate mammals, including dogs, have the ability to synthetize α-Gal and, thus, their immune system is not expected to naturally generate the antibodies toward this self-antigen molecule. However, in the current study, we detected specific IgG, IgM, and IgE antibodies to α-Gal in sera of clinically healthy dogs by an indirect enzyme-linked immunosorbent assay (ELISA) for the first time. Furthermore, in a tick infestation experiment, we showed that bites of Ixodes ricinus induce the immune response to α-Gal in dogs and that the resulting antibodies (IgM) might be protective against Anaplasma phagocytophilum. These findings may help lead to a better understanding of the underlying mechanisms involved in mammalian meat allergy and tick-host-pathogen interactions, but they also open up the question about the possibility that dogs could develop an allergy to mammalian meat after tick bites, similar to that in humans.

Meat allergy: I–Specific IgE to BSA and OSA in atopic, beef sensitive children.

1995 ◽  
Vol 14 (3) ◽  
pp. 239-244 ◽  
Author(s):  
A Fiocchi ◽  
P Restani ◽  
E Riva ◽  
R Qualizza ◽  
P Bruni ◽  
...  
Keyword(s):  
Specific Ige ◽  
Meat Allergy
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