Benefit and harm of anticoagulation in the prevention of thromboembolic stroke for non‐ valvular atrial fibrillation in haemodialysis patients ‐ a Top End of Northern Australia study

2021 ◽  
Author(s):  
By Chi Xu ◽  
Asanga Abeyaratne ◽  
Yun Hui Sheryl Wong ◽  
Sandawana William Majoni
Keyword(s):  
Atrial Fibrillation ◽  
Northern Australia ◽  
Thromboembolic Stroke

scholarly journals Prevention of stroke in chronic andrecurrent atrial fibrillation

2001 ◽  
Vol 24 (3) ◽  
pp. 61 ◽  
Author(s):  
Anne-Maree Kelly ◽  
Debra Kerr ◽  
Ruth Hew
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
American Heart ◽  
Anticoagulation Therapy ◽  
Heart Association ◽  
Chronic Atrial Fibrillation ◽  
Prior History ◽  
Demographic Information ◽  
Thromboembolic Stroke ◽  
History Of

The objective was to determine the proportion of patients presenting to the Emergency Department (ED) in atrialfibrillation (AF) who are at high risk of thromboembolic stroke as defined by the American Heart Association andwho might benefit from anticoagulation therapy.We enrolled all patients identified as having AF between 28th June 1999 and 26th March 2000. Data collectedincluded demographic information, presenting complaint, discharge diagnosis, risk factors for thromboembolic stroke,contraindications to anticoagulation (as defined by the Stroke Prevention in AF Investigators), admission anddischarge medications, and cardiac rhythm on presentation and at discharge.193 patients were identified within the study period. Two patient histories were not available for review. 121 patientshad a prior history of AF. Of these, 65 patients were at high risk for thromboembolic stroke and had no contra-indicationto anticoagulation therapy. 43 (66%) were on Warfarin at presentation but 14 (22%) were on Aspirinand 8 (12%) were on neither.34% of patients with chronic atrial fibrillation presenting to the ED, at high risk of thromboembolic stroke andwithout contra-indication to anticoagulation, were not anticoagulated on presentation. ED attendance provides anopportunity for intervention for the prevention of stroke in this group.

scholarly journals Genome-Wide Copy Number Variation Association Study of Atrial Fibrillation Related Thromboembolic Stroke

2019 ◽  
Vol 8 (3) ◽  
pp. 332 ◽  
Author(s):  
Chia-Shan Hsieh ◽  
Pang-Shuo Huang ◽  
Sheng-Nan Chang ◽  
Cho-Kai Wu ◽  
Juey-Jen Hwang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Signaling Pathway ◽  
Copy Number ◽  
Genetic Factors ◽  
Copy Number Variations ◽  
Nucleotide Polymorphisms ◽  
Thromboembolic Stroke ◽  
Genome Wide ◽  
A Genome ◽  
The Impact

Atrial fibrillation (AF) is a common cardiac arrhythmia and is one of the major causes of ischemic stroke. In addition to the clinical factors such as CHADS2 or CHADS2-VASC score, the impact of genetic factors on the risk of thromboembolic stroke in patients with AF has been largely unknown. Single-nucleotide polymorphisms in several genomic regions have been found to be associated with AF. However, these loci do not contribute to all the genetic risks of AF or AF related thromboembolic risks, suggesting that there are other genetic factors or variants not yet discovered. In the human genome, copy number variations (CNVs) could also contribute to disease susceptibility. In the present study, we sought to identify CNVs determining the AF-related thromboembolic risk. Using a genome-wide approach in 109 patients with AF and thromboembolic stroke and 14,666 controls from the Taiwanese general population (Taiwan Biobank), we first identified deletions in chromosomal regions 1p36.32-1p36.33, 5p15.33, 8q24.3 and 19p13.3 and amplifications in 14q11.2 that were significantly associated with AF-related stroke in the Taiwanese population. In these regions, 148 genes were involved, including several microRNAs and long non-recoding RNAs. Using a pathway analysis, we found deletions in GNB1, PRKCZ, and GNG7 genes related to the alpha-adrenergic receptor signaling pathway that play a major role in determining the risk of an AF-related stroke. In conclusion, CNVs may be genetic predictors of a risk of a thromboembolic stroke for patients with AF, possibly pointing to an impaired alpha-adrenergic signaling pathway in the mechanism of AF-related thromboembolism.

Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation

2013 ◽  
Vol 324 (1-2) ◽  
pp. 49-52 ◽  
Author(s):  
Gökhan Ertaş ◽  
Osman Sönmez ◽  
Murat Turfan ◽  
Şeref Kul ◽  
Ercan Erdoğan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Thromboembolic Stroke ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Left atrial appendage occlusion: an alternative to anticoagulation for stroke prevention in kidney disease

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0004082021
Author(s):  
Srikanth Vallurupalli ◽  
Tanya Sharma ◽  
Subhi Al'Aref ◽  
Subodh R. Devabhaktuni ◽  
Gaurav Dhar
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Stroke Risk ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
High Risk Population ◽  
Thromboembolic Stroke ◽  
Nonvalvular Atrial Fibrillation ◽  
Left Atrial Appendage Occlusion ◽  
Pros And Cons

Anticoagulation to reduce thromboembolic stroke risk due to nonvalvular atrial fibrillation in ESRD is associated with increased bleeding. Existing debate in ESRD centers around the pros and cons of anticoagulation. We propose percutaneous left atrial appendage occlusion as a third alternative to balance thrombosis and bleeding risks in this high risk population.

scholarly journals Epicardial obesity and atrial fibrillation: emphasis on atrial fat depot

2020 ◽  
Vol 17 (3) ◽  
pp. 316-325
Author(s):  
Evgeniy S. Mazur ◽  
Vera V. Mazur ◽  
Nikolay D. Bazhenov ◽  
Sergey V. Kolbasnicov ◽  
Oksana V. Nilova
Keyword(s):  
Atrial Fibrillation ◽  
Transesophageal Echocardiography ◽  
Strong Predictor ◽  
Interatrial Septum ◽  
Epicardial Fat ◽  
Thromboembolic Complications ◽  
Thromboembolic Stroke ◽  
Lateral Ridge ◽  
Fat Depot ◽  
The Relationship

The studies, performed with MRI and CT, showed that the increase of fat, immediately adjacent to the myocardium (epicardial fat) is correlated more strongly with the risk of atrial fibrillation than the general or abdominal obesity. According to some studies, epicardial fat around the left atrium is a strong predictor of the development at atrial fibrillation. Also, the amount of the fat is associated with the effectiveness of cardioversion and the risk of developing thromboembolic stroke in patients with atrial fibrillation. The number of such works is small, since tomographic examinations are not needed if intra-atrial thrombosis is suspected, and transthoracic echocardiograthy does not allow visualization of atrial fat. However, transesophageal echocardiography is widely used in patients with atrial fibrillation and allows to measure the structures that serve as depots of epicardial fat, namely the interatrial septum and left lateral ridge. Accumulation of epicardial fat leads to thickening of these structures. This can be used to study the relationship between epicardial obesity and the risk of thromboembolic complications in patients with atrial fibrillations.

scholarly journals Early Thromboembolic Stroke Risk of Postoperative Atrial Fibrillation Following Cardiac Surgery

2021 ◽  
Author(s):  
Ramon Pierik ◽  
Miriam Zeillemaker-Hoekstra ◽  
Thomas W.L. Scheeren ◽  
Michiel E. Erasmus ◽  
Gert-Jan R. Luijckx ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Stroke Risk ◽  
Postoperative Atrial Fibrillation ◽  
Thromboembolic Stroke
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