scholarly journals Adult‐onset Still disease post‐adenovirus vector COVID ‐19 vaccine

2021 ◽  
Vol 51 (12) ◽  
pp. 2144-2145
Author(s):  
Aoife Sweeney ◽  
Gerald Tracey ◽  
Katherine Garnham
Keyword(s):  
Adenovirus Vector ◽  
Adult Onset ◽  
Still Disease

scholarly journals Severe Adult-onset Still Disease with Constrictive Pericarditis and Pleuritis That Was Successfully Treated with Tocilizumab in Addition to Corticosteroids and Cyclosporin A

2018 ◽  
Vol 57 (7) ◽  
pp. 1033-1038 ◽  
Author(s):  
Hoshimi Kawaguchi ◽  
Hiroto Tsuboi ◽  
Mizuki Yagishita ◽  
Toshihiko Terasaki ◽  
Mayu Terasaki ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Constrictive Pericarditis ◽  
Adult Onset ◽  
Still Disease

scholarly journals 一例肺部感染引起的成人still病合并嗜血细胞综合征的护理

2020 ◽  
Vol 3 (5) ◽  
pp. 194
Author(s):  
美英 王 ◽  
玉琴 吕
Keyword(s):  
Adult Onset ◽  
Still Disease

成人 still 病 (Adult Onset Still Disease, AOSD) 是一种病因不明，发病机制不清楚，以高热、一过性多型性皮疹和关节炎或关节痛为主要临床表现，伴有周围血粒细胞增高、肝脾及淋巴结肿大等系统受累的临床综合征。其患病率低于十万分之一。噬血细胞综合征（HPS）也称为噬血细胞性淋巴组织细胞增多症（HLH），是一种威胁生命的高炎症综合征，其特征是骨髓和其他网状内皮系统中巨噬细胞和组织细胞的活化，具有显著的噬血细胞作用。主要症状包括高烧、全血细胞减少、淋巴结肿大、肝脾肿大和 SF 水平升高。由于非典型 HPS 的缺乏特异性的表现，早期诊断是困难的，临床表现复杂，给患者带来极大痛苦。

scholarly journals Dermato-pathologic clues to diagnosis of adult onset still disease: A case report

2021 ◽  
Vol 12 (5) ◽  
pp. 741
Author(s):  
Suman Patra ◽  
Tummidi Santosh ◽  
Garima Goel ◽  
Richa Rupla
Keyword(s):  
Case Report ◽  
Adult Onset ◽  
Still Disease

scholarly journals Cytokine levels in persistent skin lesions of adult-onset Still disease

2018 ◽  
Vol 79 (5) ◽  
pp. 947-949 ◽  
Author(s):  
Elina Zuelgaray ◽  
Maxime Battistella ◽  
Marie-Dominique Vignon-Pennamen ◽  
Sophie Ly Ka So ◽  
Michel Rybojad ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Adult Onset ◽  
Cytokine Levels ◽  
Still Disease

Neutrophil Extracellular Traps May Contribute to the Pathogenesis in Adult-onset Still Disease

2019 ◽  
Vol 46 (12) ◽  
pp. 1560-1569 ◽  
Author(s):  
Mi-Hyun Ahn ◽  
Jae Ho Han ◽  
Young-Jun Chwae ◽  
Ju-Yang Jung ◽  
Chang-Hee Suh ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Serum Levels ◽  
Neutrophil Extracellular Traps ◽  
Polymorphonuclear Neutrophils ◽  
Adult Onset ◽  
Cell Free Dna ◽  
Extracellular Traps ◽  
Free Dna ◽  
Still Disease

Objective.Release of neutrophil extracellular traps (NET) has been described as an effector mechanism of polymorphonuclear neutrophils in several inflammatory diseases. Thus, this study was performed to evaluate the role of NET in the pathogenesis of adult-onset Still disease (AOSD).Methods.We determined the serum levels of NET molecules and investigated their associations with clinical disease activities in patients with AOSD. Further, we analyzed the differences in the NETosis response in AOSD patients compared to healthy controls (HC). To explore the in vivo involvement of NET in AOSD, we performed immunohistochemical analysis of skin and lymph node (LN) biopsies for proteins related to NET in patients with active AOSD.Results.Serum levels of cell-free DNA, myeloperoxidase (MPO)-DNA complex, and α-defensin were significantly increased in patients with AOSD compared to HC. Serum levels of the NET molecules, cell-free DNA, MPO-DNA, and α-defensin were correlated with several disease activity markers for AOSD. In followup of patients with AOSD after treatment with corticosteroid, the levels of cell-free DNA and α-defensin decreased significantly. On immunohistochemistry, neutrophil elastase–positive and MPO-positive inflammatory cells were detected in skin and LN of patients with AOSD, and were expressed in fiber form in the lesions. The serum from patients with active AOSD induced NETosis in neutrophils from HC. NET molecules induced interleukin 1β production in monocytes, representing a novel mechanism in the pathogenesis of AOSD.Conclusion.The findings presented here suggest that NET may contribute to the inflammatory response and pathogenesis in AOSD.

scholarly journals Myocarditis in Adult-Onset Still Disease

Medicine ◽  
2014 ◽  
Vol 93 (17) ◽  
pp. 280-289 ◽  
Author(s):  
Mathieu Gerfaud-Valentin ◽  
Pascal Sève ◽  
Jean Iwaz ◽  
Anne Gagnard ◽  
Christiane Broussolle ◽  
...  
Keyword(s):  
Adult Onset ◽  
Still Disease

scholarly journals Endocarditis in Adult-onset Still Disease: A Case Report and Literature Review

2018 ◽  
Vol 45 (8) ◽  
pp. 1200-1200
Author(s):  
XIN DANG ◽  
YONGMEI HAN ◽  
XINHUA ZHANG
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Adult Onset ◽  
Still Disease

Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease

2020 ◽  
Vol 26 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Takashi Shimizu ◽  
Akie Kikuchi-Taura ◽  
Soichiro Tsuji ◽  
Masato Matsushita ◽  
Shiro Ohshima ◽  
...  
Keyword(s):  
Adult Onset ◽  
Cd64 Expression ◽  
Still Disease

scholarly journals Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis

Medicine ◽  
2017 ◽  
Vol 96 (24) ◽  
pp. e6656 ◽  
Author(s):  
Federico Parisi ◽  
Annamaria Paglionico ◽  
Valentina Varriano ◽  
Gianfranco Ferraccioli ◽  
Elisa Gremese
Keyword(s):  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Acute Myocarditis ◽  
Adult Onset ◽  
Still Disease ◽  
Activation Syndrome
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