Endurance cycle ergometry tests performed at a sub‐maximal work rate elicit peak physiological and symptom responses in adults with cystic fibrosis

2021 ◽  
Vol 51 (7) ◽  
pp. 1168-1172
Author(s):  
Abbey Sawyer ◽  
Vinicius Cavalheri ◽  
Sue Jenkins ◽  
Jamie Wood ◽  
Bhajan Singh ◽  
...  
2020 ◽  
Vol 9 (10) ◽  
pp. 3098
Author(s):  
Abbey Sawyer ◽  
Vinicius Cavalheri ◽  
Sue Jenkins ◽  
Jamie Wood ◽  
Nola Cecins ◽  
...  

Background: To optimize outcomes in people with cystic fibrosis (CF), guidelines recommend 30 to 60 min of moderate-intensity aerobic exercise on most days. Accumulating this volume of exercise contributes importantly to the substantial treatment burden associated with CF. Therefore, the main aim of this study was to investigate the effects of low-volume high-intensity interval training (HIIT) on exercise capacity in people with CF. Methods: This randomized controlled trial included people with CF aged ≥15 years, who were allocated to either eight weeks of thrice-weekly 10-min sessions of HIIT (experimental group) or eight weeks of weekly contact (control group). Before and after the intervention period, participants completed measurements of time to symptom limitation (Tlim) during a constant work rate cycle ergometry test (primary outcome), and maximal work rate (Wmax) during a ramp-based cycle ergometry test and health-related quality of life (HRQoL). Results: Fourteen participants (median (IQR) age 31 (28, 35) years, forced expiratory volume in 1 second (FEV1) 61 (45, 80) % predicted) were included (seven in each group). Compared to the control group, participants in the experimental group demonstrated a greater magnitude of change in Tlim, Wmax (p = 0.017 for both) and in the physical function domain of HRQoL (p = 0.03). No other between-group differences were demonstrated. Mild post-exercise muscle soreness was reported on a single occasion by four participants. Overall, participants attended 93% of all HIIT sessions. Discussion: Eight weeks of low-volume (i.e., 30-min/week) HIIT produced gains in exercise capacity and self-reported physical function and was well tolerated by people with CF.


1997 ◽  
Vol 29 (6) ◽  
pp. 775-780 ◽  
Author(s):  
BEN R. LONDEREE ◽  
JULIA MOFFITT-GERSTENBERGER ◽  
JAMES A. PADFIELD ◽  
DIANE LOTTMANN

1986 ◽  
Vol 61 (3) ◽  
pp. 1203-1209 ◽  
Author(s):  
B. J. Legge ◽  
E. W. Banister

Relationships among O2 uptake (VO2), heart rate, and work rate during constant-load submaximal cycle ergometry and ramp-forced exercise to exhaustion have been studied in core groups of trained (n = 15) and untrained (n = 10), 20- to 29-yr-old males. A signal aim was to improve on the accuracy of the 1954 Astrand-Ryhming (A-R) nomogram predicting maximum aerobic power from heart rate elevation at submaximum work rates. A new nomogram has been developed based on a linear relationship, established in experimental groups, between VO2 and delta HR, the latter being defined as the elevation of exercise heart rate above that reached during zero-load pedaling at 90 rpm. The delta HR variable used in a nomogram linking it and submaximum VO2 (either derived by calculation from the concomitant steady-state work rate or measured directly from respiratory gas analysis) successfully differentiated maximum aerobic power of trained from untrained subjects in core groups whose different abilities could not otherwise be distinguished by the A-R nomogram itself. In a validation group of trained (n = 5), untrained (n = 5), and moderately trained (n = 4) 20- to 29-yr-old males, the correlation measured between VO2max values and those predicted from the new nomogram was significantly better (r = 0.98) (P less than 0.05) than predictions made from the A-R nomogram (r = 0.80).


2003 ◽  
Vol 284 (4) ◽  
pp. H1251-H1259 ◽  
Author(s):  
J. G. Poole ◽  
L. Lawrenson ◽  
J. Kim ◽  
C. Brown ◽  
R. S. Richardson

We measured leg blood flow (LBF), drew arterial-venous (A-V) blood samples, and calculated muscle O2 consumption (V˙o 2) during incremental cycle ergometry exercise [15, 30, and 99 W and maximal effort (maximal work rate, WRmax)] in nine sedentary young (20 ± 1 yr) and nine sedentary old (70 ± 2 yr) males. LBF was preserved in the old subjects at 15 and 30 W. However, at 99 W and at WRmax, leg vascular conductance was attenuated because of a reduced LBF (young: 4.1 ± 0.2 l/min and old: 3.1 ± 0.3 l/min) and an elevated mean arterial blood pressure (young: 112 ± 3 mmHg and old: 132 ± 3 mmHg) in the old subjects. Leg A-V O2 difference changed little with increasing WR in the old group but was elevated compared with the young subjects. Muscle maximal V˙o 2 and cycle WRmax were significantly lower in the old subjects (young: 0.8 ± 0.05 l/min and 193 ± 7 W; old: 0.5 ± 0.03 l/min and 117 ± 10 W). The submaximally unchanged and maximally reduced cardiac output associated with aging coupled with its potential maldistiribution are candidates for the limited LBF during moderate to heavy exercise in older sedentary subjects.


2009 ◽  
Vol 34 (6) ◽  
pp. 1001-1007 ◽  
Author(s):  
Akira Miura ◽  
Chiaki Shiragiku ◽  
Yuiko Hirotoshi ◽  
Asami Kitano ◽  
Masako Yamaoka Endo ◽  
...  

The tolerable duration (t) of high-intensity cycle ergometry is well characterized by a hyperbolic function of power output (P) with an asymptote (termed the critical power (CP)) and a curvature constant (denoted W′). The purpose of this study was to investigate the effect of prior heavy exercise (W-up) that specifically engenders an acidosis on CP and W′. Eight healthy subjects performed 2 sets of 4 high-intensity square-wave exercise bouts on a bicycle ergometer to estimate CP and W′, with (W-up) and without (control) prior exercise, respectively. Exercise intensities of the 4 main bouts were selected in the range of 90% to 135% peak oxygen uptake so as to reach the limit of tolerance between approximately 1.5 and 10 min. The W-up bout was preceded by 6 min cycling at a work rate halfway between the lactate threshold and peak oxygen uptake (mean ± SD of 153.8 ± 29.8 W) starting 12 min before the main bout. Blood lactate levels ([La]b) just before the main exercise bouts in W-up conditions were significantly higher than those of the control (4.7 ± 1.1 and 1.4 ± 0.4 mEq·L–1, respectively; p < 0.05). However, there were no significant differences in end-exercise [La]b. W-up increased significantly the tolerable duration at every work rate compared with the control, which was attributable exclusively to increased CP (176.5 ± 34.3 and 168.7 ± 31.3 W, respectively; p < 0.05), without any significant change in W′ (11.0 ± 3.2 and 11.0 ± 3.1 kJ, respectively). It is concluded that the prior heavy exercise improved performance mainly because of an enhanced aerobic component of exercise energetics, as indicated by a higher CP and lower increment in the [La]b.


Respiration ◽  
2011 ◽  
Vol 81 (2) ◽  
pp. 124-128 ◽  
Author(s):  
A.E. Holland ◽  
K. Hill ◽  
J.A. Alison ◽  
N. Luxton ◽  
M.G. Mackey ◽  
...  

2006 ◽  
Vol 100 (3) ◽  
pp. 764-770 ◽  
Author(s):  
H. B. Rossiter ◽  
J. M. Kowalchuk ◽  
B. J. Whipp

The O2 uptake (V̇o2) response to ramp incremental (RI) exercise does not consistently demonstrate plateau-like behavior at the limit of tolerance, and hence the requirements for a maximum V̇o2 commonly are not met, despite apparent maximum effort. We sought to determine whether an appended step exercise (SE) test at a work rate greater than that achieved in a preceding ramp test would establish the plateau criterion. Seven healthy male adults performed RI cycle ergometry (20 W/min) to the limit of tolerance, followed by 5-min recovery (20 W) and then an SE test at 105% (RISE-105) of the final work rate (WRpeak) achieved during RI. Five of these subjects also performed an RI test followed by SE at 95% WRpeak (RISE-95). V̇o2 was measured breath by breath using a turbine and mass spectrometer. The average of the final 15 s of RI or SE was used to establish respective V̇o2 peaks. When V̇o2 peak was approached, a constant V̇o2 value (e.g., a plateau) was not discernable during any RI or SE component of the tests. Although the WRpeak [mean (SD)] was higher during the SE portion [359 W (SD 31)] than during the RI portion [341 W (SD 29)] of the RISE-105, the peak V̇o2 was not different [SE, 4.30 l/min (SD 0.51); RI, 4.33 l/min (SD 0.52); P = 0.49; n = 7]. Similarly, in the RISE-95 test, WRpeak was 310 W (SD 31) for the SE portion and 326 W (SD 32) for the RI portion, yet the peak V̇o2 values were not different [SE, 4.12 l/min (SD 0.53); RI, 4.11 l/min (SD 0.48); P = 0.78; n = 5]. The lack of notable difference between the V̇o2 peaks established at different WRpeak values in our RISE protocols provides the plateau criterion for verification of maximum V̇o2 in a single test session, even when the data response profiles do not themselves evidence a plateau.


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