Outcomes Of Non‐Cystic Fibrosis Related Bronchiectasis Post Lung Transplantation

2021 ◽  
Author(s):  
Jessica Kennedy ◽  
Anne Walker ◽  
Claire M. Ellender ◽  
Kate Steinfort ◽  
Catherine Martin ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation

scholarly journals 1458. Uncharted territories: applying “precision medicine” to understand the treacherous landscape of extensively and multidrug resistant (XDR and MDR) Pseudomonas aeruginosa in a patient with cystic fibrosis and lung transplantation

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S731-S731
Author(s):  
Laura J Rojas ◽  
Mohamad Yasmin ◽  
Jacquelynn Benjamino ◽  
Steven Marshall ◽  
Kailynn DeRonde ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Transplantation ◽  
Precision Medicine ◽  
Clinical Sample ◽  
Phylogenetic Reconstruction ◽  
Multidrug Resistant ◽  
Population Diversity ◽  
Before And After ◽  
Research Grant

Abstract Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with cystic fibrosis (CF). Herein, we describe our experience managing a young woman suffering from CF with XDR P. aeruginosa who underwent lung transplantation. We highlight the contemporary difficulties reconciling the clinical, microbiological, and genetic information. Methods Mechanism-based-susceptibility disk diffusion synergy testing with double and triple antibiotic combinations aided in choosing tailored antimicrobial combinations to control the infection in the pre-transplant period, create an effective perioperative prophylaxis regimen, and manage recurrent infections in the post-transplant period. Thirty-six sequential XDR and PDR P. aeruginosa isolates obtained from the patient within a 17-month period, before and after a double-lung transplant were analyzed by whole genome sequencing (WGS) and RNAseq in order to understand the genetic basis of the observed resistance phenotypes, establish the genomic population diversity, and define the nature of sequence changes over time Results Our phylogenetic reconstruction demonstrates that these isolates represent a genotypically and phenotypically heterogeneous population. The pattern of mutation accumulation and variation of gene expression suggests that a group of closely related strains was present in the patient prior to transplantation and continued to evolve throughout the course of treatment regardless of antibiotic usage.Our findings challenge antimicrobial stewardship programs that assist with the selection and duration of antibiotic regimens in critically ill and immunocompromised patients based on single-isolate laboratory-derived resistant profiles. We propose that an approach sampling the population of pathogens present in a clinical sample instead of single colonies be applied instead when dealing with XDR P. aeruginosa, especially in patients with CF. Conclusion In complex cases such as this, real-time combination testing and genomic/transcriptomic data could lead to the application of true “precision medicine” by helping clinicians choose the combination antimicrobial therapy most likely to be successful against a population of MDR pathogens present. Disclosures Federico Perez, MD, MS, Accelerate (Research Grant or Support)Merck (Research Grant or Support)Pfizer (Research Grant or Support) Robert A. Bonomo, MD, Entasis, Merck, Venatorx (Research Grant or Support)

scholarly journals Advances in lung transplantation for cystic fibrosis that may improve outcome

2010 ◽  
Vol 38 (5) ◽  
pp. 637-643 ◽  
Author(s):  
Pierre Mordant ◽  
Pierre Bonnette ◽  
Philippe Puyo ◽  
Edouard Sage ◽  
Dominique Grenet ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Improve Outcome

Ethical dilemma: ELX/TEZ/IVA or Lung Transplantation in Cystic Fibrosis and End Stage Lung Disease?

CHEST Journal ◽  
2021 ◽  
Author(s):  
Oded Breuer ◽  
David Shoseyov ◽  
Shifra Koretz ◽  
Nadia Alyan ◽  
Joel Reiter ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Lung Disease ◽  
Ethical Dilemma ◽  
End Stage

scholarly journals Scedosporium colonisation challenges in cystic fibrosis (CF) lung transplantation (LT) – a report of 7 monocentric series

2010 ◽  
Vol 9 ◽  
pp. S36
Author(s):  
E.M. Billaud ◽  
C. Amrein ◽  
E. Dannaoui ◽  
A. Benlmouden ◽  
P. Parize ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation

scholarly journals The First Successful Lung Transplantation in a Korean Child with Cystic Fibrosis

2017 ◽  
Vol 32 (12) ◽  
pp. 2073 ◽  
Author(s):  
Soo Ran Noh ◽  
Eun Lee ◽  
Jisun Yoon ◽  
Sungsu Jung ◽  
Song-I Yang ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Korean Child

Effect of infection with transmissible strains of Pseudomonas aeruginosa on lung transplantation outcomes in patients with cystic fibrosis

2015 ◽  
Vol 34 (4) ◽  
pp. 588-593 ◽  
Author(s):  
Nadim Srour ◽  
Cecilia Chaparro ◽  
Katherine Vandemheen ◽  
Lianne G. Singer ◽  
Shaf Keshavjee ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Lung Transplantation ◽  
Transplantation Outcomes
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