Ketogenic diet in drug‐resistant epilepsy with encephalopathy

2020 ◽  
Vol 50 (10) ◽  
pp. 1291-1292
Author(s):  
Eileen J. Mc Manus ◽  
Stacey Mc Coy ◽  
Christopher D. P. Lynch ◽  
Matthew C. L. Phillips
Keyword(s):  
Ketogenic Diet ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

Long-term effectiveness and adverse effects of ketogenic diet therapy in infants with drug-resistant epilepsy treated at a single center in Argentina

2021 ◽  
pp. 106793
Author(s):  
Marisa Armeno ◽  
Antonella Verini ◽  
Eugenia Caballero ◽  
Araceli Cresta ◽  
Gabriela Reyes Valenzuela ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Ketogenic Diet ◽  
Diet Therapy ◽  
Drug Resistant ◽  
Single Center ◽  
Drug Resistant Epilepsy

scholarly journals Ketogenic diet in Zambia: Managing drug-resistant epilepsy in a low and middle income country

2020 ◽  
Vol 14 ◽  
pp. 100380
Author(s):  
Kafula Lisa Nkole ◽  
Nfwama Kawatu ◽  
Archana A. Patel ◽  
Chimbizyani Kanyinji ◽  
Theresa Njobvu ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Middle Income Country ◽  
Income Country ◽  
Drug Resistant ◽  
Middle Income ◽  
Drug Resistant Epilepsy ◽  
Low And Middle Income

scholarly journals Ketogenic Diet Therapies for Seizures and Status Epilepticus

2020 ◽  
Vol 40 (06) ◽  
pp. 719-729
Author(s):  
Tanya J. W. McDonald ◽  
Mackenzie C. Cervenka
Keyword(s):  
Status Epilepticus ◽  
Ketogenic Diet ◽  
Care Setting ◽  
Drug Resistant ◽  
Anesthetic Agents ◽  
Ketogenic Diets ◽  
Potential Efficacy ◽  
Low Carbohydrate ◽  
History Of ◽  
Drug Resistant Epilepsy

AbstractKetogenic diet therapies are high-fat, low-carbohydrate diets designed to mimic a fasting state. Although initially developed nearly one century ago for seizure management, most clinical trials for the management of drug-resistant epilepsy in children as well as adults have been conducted over the last 3 decades. Moreover, ketogenic diets offer promising new adjunctive strategies in the critical care setting for the resolution of acute status epilepticus when traditional antiseizure drugs and anesthetic agents fail. Here, we review the history of ketogenic diet development, the clinical evidence supporting its use for the treatment of drug-resistant epilepsy in children and adults, and the early evidence supporting ketogenic diet feasibility, safety, and potential efficacy in the management of status epilepticus.

Use of the ketogenic diet in drug resistant epilepsy syndromes during early infancy: Differences between 3: 1 and 4: 1 formula, a pilot study

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
A Dressler ◽  
P Zarits ◽  
E Reithofer ◽  
F Benninger ◽  
A Mühlebner ◽  
...  
Keyword(s):  
Pilot Study ◽  
Ketogenic Diet ◽  
Early Infancy ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

scholarly journals Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1442 ◽  
Author(s):  
Ferraris ◽  
Guglielmetti ◽  
Pasca ◽  
De Giorgis ◽  
Ferraro ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Growth Retardation ◽  
Glucose Transporter ◽  
Linear Growth ◽  
Deficiency Syndrome ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy ◽  
Age Range ◽  
The Impact

Data on the impact of the ketogenic diet (KD) on children’s growth remain controversial. Here, we retrospectively investigated the occurrence of linear growth retardation in 34 children (47% males; age range: 2−17 years) diagnosed with drug-resistant epilepsy (DRE; n = 14) or glucose transporter type 1 deficiency syndrome (GLUT1-DS; n = 20) who had been treated with the KD for 12 months. The general characteristics of children with and without growth retardation were also compared. All participants received a full-calorie, traditional KD supplemented with vitamins, minerals, and citrate. Most children (80%; 11/14 in the DRE subgroup and 16/20 in the GLUT1-DS subgroup) treated with the KD did not show growth retardation at 12 months. Although participants with and without delay of growth did not differ in terms of baseline clinical characteristics, dietary prescriptions, or supplementation patterns, marked ketosis at 12 months tended to occur more frequently in the latter group. Altogether, our results indicate that growth retardation may occur in a minority of children treated with the KD. However, further research is required to identify children at risk and to clarify how increased ketones levels may affect endocrine pathways regulating growth during KD administration.

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