Novel oral anticoagulant drugs and severe oesophagitis dissecans

2016 ◽  
Vol 46 (12) ◽  
pp. 1456-1457 ◽  
Author(s):  
R. Cox ◽  
E. Roche ◽  
S. Fairley
2015 ◽  
Vol 242 (2) ◽  
pp. 639-646 ◽  
Author(s):  
Tomoya Hara ◽  
Daiju Fukuda ◽  
Kimie Tanaka ◽  
Yasutomi Higashikuni ◽  
Yoichiro Hirata ◽  
...  

EP Europace ◽  
2018 ◽  
Vol 20 (suppl_1) ◽  
pp. i70-i71
Author(s):  
A Monteiro ◽  
P Cunha ◽  
M Oliveira ◽  
M Cruz ◽  
S Aguiar ◽  
...  

2018 ◽  
Vol 5 (1) ◽  
pp. 11
Author(s):  
Daniela Dobrovoljski

Oral anticoagulant drugs (OALs) are effective agents in the prevention and treatment of thromboembolic complications. However, despite standardization and application progression, OALs represent a significant clinical problem because they are small-therapeutic medicines that easily interact with food and medicine, which can substantially affect the increased or weakened therapeutic effect. Oral anticoagulants are 4-hydroxycoumarin derivatives and vitamin K antagonists, and their pharmacological activity is based on inhibition of the synthesis of coagulation factors in the liver. These drugs are effective in the prevention of venous thromboembolism, acute myocardial infarction (AIM), heart rhythm disorders by type of atrial fibrillation, stroke prevention, and the like. The most important and clinically commonly undesirable effect of OAL is bleeding. The risk of bleeding is greatest during the introduction of the drug in therapy and for the first few months of the onset of therapy. HAS-BLED scor is a skoring system developed to estimate the 1-year risk of major bleeding in patients with atrial fibrillation and is also used for other indications.


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