Diagnostic utility of bone marrow examination for the assessment of patients with fever of unknown origin: a 10-year single-centre experience

2014 ◽  
Vol 44 (6) ◽  
pp. 610-612 ◽  
Author(s):  
J. Labrador ◽  
E. Pérez-López ◽  
A. Martín ◽  
M. Cabrero ◽  
N. Puig ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Bone Marrow Examination ◽  
Diagnostic Utility ◽  
Single Centre ◽  
Single Centre Experience

Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS

2015 ◽  
Vol 68 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Andrés E Quesada ◽  
Ashok Tholpady ◽  
Audrey Wanger ◽  
Andy N D Nguyen ◽  
Lei Chen
Keyword(s):  
Bone Marrow ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Bone Marrow Examination ◽  
Hiv Aids

Diagnostic yield of bone marrow examination in fever of unknown origin

2003 ◽  
Vol 115 (7) ◽  
pp. 591-592 ◽  
Author(s):  
Shahid Ahmed ◽  
Anita K. Siddiqui ◽  
Bhoomi Mehrotra
Keyword(s):  
Bone Marrow ◽  
Fever Of Unknown Origin ◽  
Diagnostic Yield ◽  
Unknown Origin ◽  
Bone Marrow Examination

Fever of unknown origin in 185 paediatric patients: A single-centre experience

2006 ◽  
Vol 95 (4) ◽  
pp. 463-466 ◽  
Author(s):  
Srdjan Pasic ◽  
Aleksandra Minic ◽  
Predrag Djuric ◽  
Dragan Micic ◽  
Milos Kuzmanovic ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Single Centre ◽  
Paediatric Patients ◽  
Single Centre Experience

scholarly journals Bone marrow evaluation in patients with fever of unknown origin

1970 ◽  
Vol 2 (3) ◽  
pp. 231-240 ◽  
Author(s):  
A Jha ◽  
RC Adhikari ◽  
R Sarda
Keyword(s):  
Bone Marrow ◽  
Blood Vessels ◽  
Cell Lines ◽  
Fever Of Unknown Origin ◽  
Hematological Parameters ◽  
Connective Tissue Diseases ◽  
Unknown Origin ◽  
Bone Marrow Examination ◽  
Infectious Agents ◽  
Collagen Vascular Diseases

Bone marrow examination is commonly requested investigations in cases of fever of unknown origin, irrespective of alteration in hematological parameters. More than 200 etiologies are associated with fever of unknown origin, and they are broadly divided into infectious, neoplastic, collagen vascular diseases, miscellaneous and undiagnosed. Many of these conditions directly or indirectly affect bone marrow. Marrow may show changes in cellular components, interstitium or in the blood vessels depending on the underlying local or systemic conditions. The three main hematopoietic cell lines may show variable hyperplasia, hypoplasia or aplasia of one or more than one cell lines, and occasionally dyspoiesis. Interstitium may show fibrosis, gelatinous transformation, or infiltration by abnormal cells. Amyloid deposits may be seen around blood vessels. Marrow may also show granulomas, infectious agents or neoplastic cells. Various reactive changes can be seen in the bone marrow in neoplastic, infectious and in connective tissue diseases. Infectious agents can be cultured from the marrow aspirate or can be demonstrated in marrow. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6029 JPN 2012; 2(3): 231-240

Fever of unknown origin in 185 paediatric patients: A single-centre experience

2007 ◽  
Vol 95 (4) ◽  
pp. 463-466
Author(s):  
Srdjan Pasic ◽  
Aleksandra Minic ◽  
Predrag Djuric ◽  
Dragan Micic ◽  
Milos Kuzmanovic ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Single Centre ◽  
Paediatric Patients ◽  
Single Centre Experience

scholarly journals Diagnostic utility of clinical and epidemiologic features in fever of unknown origin

2019 ◽  
Author(s):  
Victor Roca Campañá ◽  
Rosa Eugenia Jiménez Paneque ◽  
Héctor Manuel Rodríguez Silva
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Utility ◽  
Epidemiologic Features

The Certainty of a Post-Bone Marrow Diagnosis: A Study of the Yield of Bone Marrow Biopsies in a Community Hospital Setting

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 34-35
Author(s):  
Manasi M. Godbole ◽  
Peter A. Kouides
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Fever Of Unknown Origin ◽  
Conflicts Of Interest ◽  
Diagnostic Yield ◽  
Hospital Setting ◽  
Unknown Origin ◽  
Nutritional Deficiencies ◽  
Bone Marrow Biopsies

Introduction: Most studies on the diagnostic yield of bone marrow biopsy including the one by Hot et al. have focused on the yield of bone marrow biopsies in diagnosing the source of fever of unknown origin. However, there have not been any studies performed to our knowledge looking at overall practice patterns and yield of bone marrow biopsies for diagnoses other than fever of unknown origin. We aim to determine the most common indications for performing bone marrow biopsies in a community-based teaching hospital as well as the yield of the biopsies in patients with specified and unspecified pre-test indications to estimate the rate of uncertain post-test diagnoses. Methods: We performed a retrospective data collection study at Rochester General Hospital, NY. A comprehensive search was conducted in our electronic medical data to identify all patients who underwent bone marrow biopsies over a 5 year period from January 2011 - December 2016 for indications other than fever of unknown origin. Patient data including demographics, pre-bone marrow biopsy diagnosis and post-bone marrow diagnosis was obtained. All patients above the age of 18 who underwent bone marrow biopsy for indications other than fever of unknown origin or follow up treatment of a hematological malignancy were included. Results: A total of 223 biopsies were performed. The median age was 59 years (age range- 23-95). One hundred and sixteen patients were male and 107 were female. The most common indications for performing bone marrow biopsy were evaluation of the following possible conditions: multiple myeloma (n=54), myelodysplastic syndrome [MDS] (n=47), lymphoma (n=28) and leukemia (n=18) as well as non-specific indications such as pancytopenia (n=40), anemia (n=22) and thrombocytopenia (n=11). The proportion of cases confirmed by bone marrow biopsy was 45/54 (83%) with the pre-marrow diagnosis of multiple myeloma, 34/47 cases (72%) with the pre-marrow diagnosis of MDS, 15/18 (83%) with the pre-marrow diagnosis of leukemia and 13/28 (46%) in those with the pre-marrow diagnosis of rule out lymphoma. Thirteen cases (18%) with possible MDS had post-bone marrow diagnoses of leukemia, anemia of chronic disease, myelofibrosis or medication-related changes. Five out of twenty two cases (23%) for anemia and 3/11 cases (27%) for thrombocytopenia without otherwise specified pre-bone marrow etiology had uncertain diagnosis after bone marrow biopsy. Conclusion: In about a fifth of patients necessitating a bone marrow, the diagnosis is discordant and can be surprising. It is also worth reporting that in these discordant results, non-hematological causes such as medications, anemia due to chronic diseases or conditions such as cirrhosis or splenomegaly from other etiologies were among the final diagnoses. Interestingly, 20% of the patients with unspecified pre-bone marrow diagnoses such as anemia or thrombocytopenia in our study had an unclear post-bone marrow diagnosis despite undergoing bone marrow biopsy. Our findings are a reminder that the bone marrow exam does not always lead to a definitive diagnosis and the need by exclusion to include in the differential non-hematological etiologies such as nutritional deficiencies, chronic kidney disease or autoimmune disorders. Disclosures No relevant conflicts of interest to declare.

scholarly journals Localized lymphadenopathy with myelodysplastic syndrome associated with tuberculosis

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Aya Nakaya ◽  
Kazuyoshi Ishii ◽  
Toshiki Shimizu ◽  
Takeshi Tamaki ◽  
Yoshihisa Ishiura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Myelodysplastic Syndrome ◽  
Valve Replacement ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Replacement Surgery ◽  
Laboratory Examinations ◽  
Valve Replacement Surgery

We report the case of a man who developed myelodysplastic syndrome (MDS) and refractory cytopenia of unilineage dysplasia, 5 months after aortic valve replacement surgery. He also developed fever of unknown origin. After bone marrow- and other laboratory examinations, he was diagnosed with tuberculosis.

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