Impact of Type 2 Diabetes on the capacity of human macrophages infected with Mycobacterium tuberculosis to modulate monocyte differentiation through a bystander effect

2021 ◽  
Author(s):  
Monica Alejandra Valtierra‐Alvarado ◽  
Geanncarlo Lugo‐Villarino ◽  
Fátima Dueñas‐Arteaga ◽  
Beatriz Elena González‐Contreras ◽  
Anahí Lugo‐Sánchez ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Bystander Effect ◽  
Monocyte Differentiation ◽  
Human Macrophages

scholarly journals Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis

2018 ◽  
Vol 113 (4) ◽  
Author(s):  
Nallely Lopez-Lopez ◽  
Ana Gabriela Ramos Martinez ◽  
Mariana Haydee Garcia-Hernandez ◽  
Rogelio Hernandez-Pando ◽  
Julio Enrique Castañeda-Delgado ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Human Macrophages ◽  
Basal Phenotype ◽  
And Control

scholarly journals Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

2020 ◽  
Vol 65 (1) ◽  
pp. e01422-20
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Diabetic Mice ◽  
Antidiabetic Drug ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Content Type

ABSTRACTComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

scholarly journals IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis

2019 ◽  
Vol 15 (12) ◽  
pp. e1008140 ◽  
Author(s):  
Deepak Tripathi ◽  
Rajesh Kumar Radhakrishnan ◽  
Ramya Sivangala Thandi ◽  
Padmaja Paidipally ◽  
Kamakshi Prudhula Devalraju ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type 3

scholarly journals Type 2 Diabetes Mellitus

2019 ◽  
Author(s):  
Vishwanath Venketaraman ◽  
Aram Yegiazaryan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Altered Metabolism

Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

2020 ◽  
Author(s):  
Stacey Bartlett ◽  
Adrian Tandhyka Gemiarto ◽  
Minh Dao Ngo ◽  
Haressh Sajiir ◽  
Semira Hailu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Severity ◽  
Mycobacterial Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Important Regulator ◽  
Chest X Ray ◽  
Mycobacterial Growth

AbstractOxidized cholesterols have emerged as important signaling molecules of immune function, but little is known about the role of these oxysterols during mycobacterial infections. We found that expression of the oxysterol-receptor GPR183 was reduced in blood from patients with tuberculosis (TB) and type 2 diabetes (T2D) compared to TB patients without T2D and was associated with TB disease severity on chest x-ray. GPR183 activation by 7α,25-hydroxycholesterol (7α,25-OHC) reduced growth of Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis BCG in primary human monocytes, an effect abrogated by the GPR183 antagonist GSK682753. Growth inhibition was associated with reduced IFN-β and IL-10 expression and enhanced autophagy. Mice lacking GPR183 had significantly increased lung Mtb burden and dysregulated IFNs during early infection. Together, our data demonstrate that GPR183 is an important regulator of intracellular mycobacterial growth and interferons during mycobacterial infection.Graphical Abstract

scholarly journals Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice

2020 ◽  
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Tuberculosis Infection ◽  
Diabetic Mice ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Global Control

AbstractComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals.

scholarly journals BCG vaccination reduces the mortality of Mycobacterium tuberculosis–infected type 2 diabetes mellitus mice

JCI Insight ◽  
2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Rajesh Kumar Radhakrishnan ◽  
Ramya Sivangala Thandi ◽  
Deepak Tripathi ◽  
Padmaja Paidipally ◽  
Madeline Kay McAllister ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Bcg Vaccination

Immunological response to Mycobacterium tuberculosis infection in blood from type 2 diabetes patients

2017 ◽  
Vol 186 ◽  
pp. 41-45 ◽  
Author(s):  
Sara Raposo-García ◽  
José Manuel Guerra-Laso ◽  
Silvia García-García ◽  
Javier Juan-García ◽  
Eduardo López-Fidalgo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Immunological Response ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Diabetes Patients
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