scholarly journals The rise and fall of bone marrow plasma cells after influenza vaccination

2020 ◽  
Author(s):  
Marios Koutsakos ◽  
Ali H Ellebedy
Keyword(s):  
Bone Marrow ◽  
Influenza Vaccination ◽  
Plasma Cells ◽  
Bone Marrow Plasma

scholarly journals Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination

Science ◽  
2020 ◽  
Vol 370 (6513) ◽  
pp. 237-241 ◽  
Author(s):  
Carl W. Davis ◽  
Katherine J. L. Jackson ◽  
Megan M. McCausland ◽  
Jaime Darce ◽  
Cathy Chang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Immune Responses ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Plasma Cells ◽  
Serum Antibody ◽  
Universal Vaccine ◽  
Bone Marrow Plasma ◽  
Antibody Levels

A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPCs), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPCs 4 weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their prevaccination levels after 1 year. This decline was driven by the loss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained. Our results suggest that most BMPCs generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.

scholarly journals Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10

2019 ◽  
Vol 10 ◽  
Author(s):  
Lingzhang Meng ◽  
Larissa Nogueira Almeida ◽  
Ann-Katrin Clauder ◽  
Timo Lindemann ◽  
Julia Luther ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Plasma Cells ◽  
Myeloid Lineage ◽  
Lineage Differentiation ◽  
Bone Marrow Plasma

scholarly journals Multiple myeloma: circulating lymphocytes that express plasma cell antigens

Blood ◽  
1984 ◽  
Vol 64 (2) ◽  
pp. 352-356
Author(s):  
GJ Ruiz-Arguelles ◽  
JA Katzmann ◽  
PR Greipp ◽  
NJ Gonchoroff ◽  
JP Garton ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cell ◽  
Peripheral Blood ◽  
Plasma Cells ◽  
Peripheral Blood Lymphocytes ◽  
Tumor Burden ◽  
B Cell Differentiation ◽  
Blood Lymphocytes ◽  
Bone Marrow Plasma

The bone marrow and peripheral blood of 14 patients with multiple myeloma were studied with murine monoclonal antibodies that identify antigens on plasma cells (R1–3 and OKT10). Peripheral blood lymphocytes expressing plasma cell antigens were found in six cases. Five of these cases expressed the same antigens that were present on the plasma cells in the bone marrow. Patients that showed such peripheral blood involvement were found to have a larger tumor burden and higher bone marrow plasma cell proliferative activity. In some patients, antigens normally found at earlier stages of B cell differentiation (B1, B2, and J5) were expressed by peripheral blood lymphocytes and/or bone marrow plasma cells.

scholarly journals LONG-LIVED BONE MARROW PLASMA CELLS DURING IMMUNE RESPONSE TO ALPHA (1→3) DEXTRAN

2015 ◽  
Vol 17 (2) ◽  
pp. 127
Author(s):  
I. N. Chernyshova ◽  
M. V. Gavrilova ◽  
L. V. Komarova ◽  
E. V. Sidorova
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Plasma Cells ◽  
Bone Marrow Plasma
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