scholarly journals The rise and fall of bone marrow plasma cells after influenza vaccination

Author(s):  
Marios Koutsakos ◽  
Ali H Ellebedy
Science ◽  
2020 ◽  
Vol 370 (6513) ◽  
pp. 237-241 ◽  
Author(s):  
Carl W. Davis ◽  
Katherine J. L. Jackson ◽  
Megan M. McCausland ◽  
Jaime Darce ◽  
Cathy Chang ◽  
...  

A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPCs), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPCs 4 weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their prevaccination levels after 1 year. This decline was driven by the loss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained. Our results suggest that most BMPCs generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.


2019 ◽  
Vol 10 ◽  
Author(s):  
Lingzhang Meng ◽  
Larissa Nogueira Almeida ◽  
Ann-Katrin Clauder ◽  
Timo Lindemann ◽  
Julia Luther ◽  
...  

Blood ◽  
1984 ◽  
Vol 64 (2) ◽  
pp. 352-356
Author(s):  
GJ Ruiz-Arguelles ◽  
JA Katzmann ◽  
PR Greipp ◽  
NJ Gonchoroff ◽  
JP Garton ◽  
...  

The bone marrow and peripheral blood of 14 patients with multiple myeloma were studied with murine monoclonal antibodies that identify antigens on plasma cells (R1–3 and OKT10). Peripheral blood lymphocytes expressing plasma cell antigens were found in six cases. Five of these cases expressed the same antigens that were present on the plasma cells in the bone marrow. Patients that showed such peripheral blood involvement were found to have a larger tumor burden and higher bone marrow plasma cell proliferative activity. In some patients, antigens normally found at earlier stages of B cell differentiation (B1, B2, and J5) were expressed by peripheral blood lymphocytes and/or bone marrow plasma cells.


2015 ◽  
Vol 17 (2) ◽  
pp. 127
Author(s):  
I. N. Chernyshova ◽  
M. V. Gavrilova ◽  
L. V. Komarova ◽  
E. V. Sidorova

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