scholarly journals Impact of salt and the osmoprotective transcription factor NFAT‐5 on macrophages during mechanical strain

2020 ◽  
Vol 99 (1) ◽  
pp. 84-96
Author(s):  
Agnes Schröder ◽  
Alexandra Leikam ◽  
Paul Käppler ◽  
Patrick Neubert ◽  
Jonathan Jantsch ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mechanical Strain ◽  
Transcription Factor Nfat

scholarly journals Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells?

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Bin Zhang ◽  
Wei Shi
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Cyclosporine A ◽  
Immunosuppressive Effect ◽  
Molecular Event ◽  
Podocyte Injury ◽  
Antiproteinuric Effect ◽  
Nfat Activation ◽  
Per Se ◽  
Transcription Factor Nfat

The antiproteinuric effect of cyclosporine A(CsA) has been believed to result from its immunosuppressive effect on the transcription factor NFAT in T cells. However, current evidences supporting this hypothesis are missing. A recent study showed that CsA has a direct antiproteinuric effect on podocytes, suggesting a novel non-immunosuppressive mechanism for CsA's antiproteinuric effect. Conditional NFATc1 activation in podoyctes per se is sufficient to induce proteinuria in mice, indicating that NFAT activation in podocytes is a critical pathogenic molecular event leading to podocyte injury and proteinuria. Meanwhile, evidence showed that TRPC6-mediated Ca2+influx stimulates NFAT-dependent TRPC6 expression. Altogether, these advances in podocyte research indicate that calcineurin-NFAT signal or calcineurin-synaptopodin axis has a direct proteinuric effect on podocytes which raises the possibility of developing specific antiproteinuric drugs that lack the unwanted effects of calcineurin or NFAT inhibition.

scholarly journals Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT

2006 ◽  
Vol 22 (1) ◽  
pp. 145
Author(s):  
Merav Yoeli-Lerner ◽  
Gary K. Yiu ◽  
Isaac Rabinovitz ◽  
Peter Erhardt ◽  
Sebastien Jauliac ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Motility ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Motility ◽  
Transcription Factor Nfat

scholarly journals The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

2011 ◽  
Vol 12 (11) ◽  
pp. 1063-1070 ◽  
Author(s):  
Zhihua Liu ◽  
Jinwoo Lee ◽  
Scott Krummey ◽  
Wei Lu ◽  
Huaibin Cai ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Transcription Factor ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Transcription Factor Nfat

scholarly journals Isoform-specific Regulation Of The Ca-sensitive Transcription Factor NFAT In The Cardiovascular System

2009 ◽  
Vol 96 (3) ◽  
pp. 559a ◽  
Author(s):  
Andreas Rinne ◽  
Kathrin Banach ◽  
Donald M. Bers ◽  
Lothar A. Blatter
Keyword(s):  
Transcription Factor ◽  
Cardiovascular System ◽  
Specific Regulation ◽  
Transcription Factor Nfat
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