scholarly journals Kinks in the chain: examining recombination‐activating gene scanning during V(D)J recombination

2019 ◽  
Vol 97 (10) ◽  
pp. 859-861
Author(s):  
Timothy M Johanson ◽  
Rhys S Allan
Keyword(s):  
Recombination Activating Gene ◽  
Gene Scanning

Omenn Syndrome Caused By a Novel Homozygous Mutation in Recombination Activating Gene 1

Immunobiology ◽  
2021 ◽  
pp. 152090
Author(s):  
Ibtihal Benhsaien ◽  
Soukaina Essadssi ◽  
Lamiae Elkhattabi ◽  
Amina Bakhchane ◽  
Houria Abdelghaffar ◽  
...  
Keyword(s):  
Omenn Syndrome ◽  
Homozygous Mutation ◽  
Recombination Activating Gene

High-Resolution Melting Analyses for Gene Scanning of APC, MLH1, MSH2, and MSH6 Associated with Hereditary Colorectal Cancer

2012 ◽  
Vol 16 (5) ◽  
pp. 406-411 ◽  
Author(s):  
Jurat Obul ◽  
Sakae Itoga ◽  
Maynur Abliz ◽  
Kenichi Sato ◽  
Takayuki Ishige ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Resolution ◽  
High Resolution Melting ◽  
Hereditary Colorectal Cancer ◽  
Gene Scanning

scholarly journals Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

2002 ◽  
Vol 196 (4) ◽  
pp. 469-480 ◽  
Author(s):  
Michael J. Difilippantonio ◽  
Simone Petersen ◽  
Hua Tang Chen ◽  
Roger Johnson ◽  
Maria Jasin ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Cleavage ◽  
Chromosomal Rearrangements ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Telomere Capture ◽  
Culture Models ◽  
Recombination Activating Gene ◽  
Dna Repair Protein ◽  
Break Induced Replication

Nonreciprocal translocations and gene amplifications are commonly found in human tumors. Although little is known about the mechanisms leading to such aberrations, tissue culture models predict that they can arise from DNA breakage, followed by cycles of chromatid fusion, asymmetric mitotic breakage, and replication. Mice deficient in both a nonhomologous end joining (NHEJ) DNA repair protein and the p53 tumor suppressor develop lymphomas at an early age harboring amplification of an IgH/c-myc fusion. Here we report that these chromosomal rearrangements are initiated by a recombination activating gene (RAG)-induced DNA cleavage. Subsequent DNA repair events juxtaposing IgH and c-myc are mediated by a break-induced replication pathway. Cycles of breakage-fusion-bridge result in amplification of IgH/c-myc while chromosome stabilization occurs through telomere capture. Thus, mice deficient in NHEJ provide excellent models to study the etiology of unbalanced translocations and amplification events during tumorigenesis.

The Recombination Activating Gene and Lymphoid Differentiation

1989 ◽  
pp. 385-388
Author(s):  
D. Baltimore ◽  
M. Oettinger ◽  
D. Schatz
Keyword(s):  
Recombination Activating Gene
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