scholarly journals Pharmacological blockade of the CD 39/ CD 73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐ versus ‐host disease

2019 ◽  
Vol 97 (6) ◽  
pp. 597-610 ◽  
Author(s):  
Nicholas J Geraghty ◽  
Debbie Watson ◽  
Ronald Sluyter
Keyword(s):  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Adenosine Receptors ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Host Disease ◽  
Graft Versus Host ◽  
Pharmacological Blockade

scholarly journals Correction: Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
Author(s):  
Matthew B. Greenblatt ◽  
Vladimir Vrbanac ◽  
Trevor Tivey ◽  
Kelly Tsang ◽  
Andrew M. Tager ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Host Disease ◽  
Graft Versus Host

Immunomodulatory Effect of IVIG in a Humanized Mouse Model of Graft-versus-host Disease

2010 ◽  
Vol 135 ◽  
pp. S92
Author(s):  
Joelle Gregoire-Gauthier ◽  
François Fontaine ◽  
Arnaud Duval ◽  
Ludovic Durrieu ◽  
Mame Massar Dieng ◽  
...  
Keyword(s):  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Immunomodulatory Effect ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44664 ◽  
Author(s):  
Matthew B. Greenblatt ◽  
Vladimir Vbranac ◽  
Trevor Tivey ◽  
Kelly Tsang ◽  
Andrew M. Tager ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Compound a Increases Cell Infiltration in Target Organs of Acute Graft-versus-Host Disease (aGVHD) in a Mouse Model

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4237
Author(s):  
Abdellatif Bouazzaoui ◽  
Ahmed A. H. Abdellatif ◽  
Faisal A. Al-Allaf ◽  
Neda M. Bogari ◽  
Mohiuddin M. Taher ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Cell Infiltration ◽  
Compound A ◽  
Host Disease ◽  
Graft Versus Host ◽  
Target Organs ◽  
Acute Graft

Systemic steroids are used to treat acute graft-versus-host disease (aGVHD) caused by allogenic bone marrow transplantation (allo-BMT); however, their prolonged use results in complications. Hence, new agents for treating aGVHD are required. Recently, a new compound A (CpdA), with anti-inflammatory activity and reduced side effects compared to steroids, has been identified. Here, we aimed to determine whether CpdA can improve the outcome of aGVHD when administered after transplantation in a mouse model (C57BL/6 in B6D2F1). After conditioning with 9Gy total body irradiation, mice were infused with bone marrow (BM) cells and splenocytes from either syngeneic (B6D2F1) or allogeneic (C57BL/6) donors. The animals were subsequently treated (3 days/week) with 7.5 mg/kg CpdA from day +15 to day +28; the controls received 0.9% NaCl. Thereafter, the incidence and severity of aGVHD in aGVHD target organs were analyzed. Survival and clinical scores did not differ significantly; however, CpdA-treated animals showed high cell infiltration in the target organs. In bulk mixed lymphocyte reactions, CpdA treatment reduced the cell proliferation and expression of inflammatory cytokines and chemokines compared to controls, whereas levels of TNF, IL-23, chemokines, and chemokine receptors increased. CpdA significantly reduced proliferation in vitro but increased T cell infiltration in target organs.

Post‐transplant cyclophosphamide limits reactive donor T cells and delays the development of graft‐versus‐host disease in a humanised mouse model

Immunology ◽  
2021 ◽  
Author(s):  
Sam Raj Adhikary ◽  
Peter Cuthbertson ◽  
Leigh Nicholson ◽  
Katrina M. Bird ◽  
Chloe Sligar ◽  
...  
Keyword(s):  
T Cells ◽  
Mouse Model ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Post Transplant ◽  
Donor T Cells
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