scholarly journals LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

2018 ◽  
Vol 96 (9) ◽  
pp. 981-993 ◽  
Author(s):  
Damien Zanker ◽  
Kenneth Pang ◽  
Sara Oveissi ◽  
Chunni Lu ◽  
Pierre Faou ◽  
...  
Keyword(s):  
Lymphocyte Survival

The role of Rel/NF-κB transcription factors in B lymphocyte survival

2003 ◽  
Vol 15 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Steve Gerondakis ◽  
Andreas Strasser
Keyword(s):  
Transcription Factors ◽  
B Lymphocyte ◽  
Lymphocyte Survival

BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development

2009 ◽  
pp. 19-41 ◽  
Author(s):  
Wasif N. Khan ◽  
Nicholas P. Shinners ◽  
Iris Castro ◽  
Kristen L. Hoek
Keyword(s):  
B Lymphocyte ◽  
Receptor Regulation ◽  
Survival And Development ◽  
Lymphocyte Survival

Lymphocyte Survival: A Red Queen Hypothesis

Science ◽  
1997 ◽  
Vol 277 (5334) ◽  
pp. 1950-1950 ◽  
Author(s):  
Antonio A. Freitas ◽  
Benedita Rocha
Keyword(s):  
Red Queen Hypothesis ◽  
Red Queen ◽  
Lymphocyte Survival

scholarly journals Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension

2016 ◽  
Vol 36 (8) ◽  
pp. 1638-1646 ◽  
Author(s):  
Sri N. Batchu ◽  
Angie Hughson ◽  
Kristine M. Wadosky ◽  
Craig N. Morrell ◽  
Deborah J. Fowell ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Survival

158 Altered T-lymphocyte survival occurs as a result of interaction with the prostate cancer microenvironment

2004 ◽  
Vol 3 (2) ◽  
pp. 42
Author(s):  
S. Shine ◽  
N. Farrell ◽  
R.N.T. Coffey ◽  
J.M. Fitzpatrick ◽  
W.R.G. Watson
Keyword(s):  
Prostate Cancer ◽  
T Lymphocyte ◽  
Cancer Microenvironment ◽  
Lymphocyte Survival

scholarly journals Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 ◽  
Vol 191 (10) ◽  
pp. 1721-1734 ◽  
Author(s):  
Russell G. Jones ◽  
Michael Parsons ◽  
Madeleine Bonnard ◽  
Vera S.F. Chan ◽  
Wen-Chen Yeh ◽  
...  
Keyword(s):  
T Cells ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Protein Kinase B ◽  
Active Form ◽  
Nuclear Factor ◽  
Clonal Deletion ◽  
Lymphocyte Survival

The serine/threonine kinase protein kinase B (PKB)/Akt mediates cell survival in a variety of systems. We have generated transgenic mice expressing a constitutively active form of PKB (gag-PKB) to examine the effects of PKB activity on T lymphocyte survival. Thymocytes and mature T cells overexpressing gag-PKB displayed increased active PKB, enhanced viability in culture, and resistance to a variety of apoptotic stimuli. PKB activity prolonged the survival of CD4+CD8+ double positive (DP) thymocytes in fetal thymic organ culture, but was unable to prevent antigen-induced clonal deletion of thymocytes expressing the major histocompatibility complex class I–restricted P14 T cell receptor (TCR). In mature T lymphocytes, PKB can be activated in response to TCR stimulation, and peptide-antigen–specific proliferation is enhanced in T cells expressing the gag-PKB transgene. Both thymocytes and T cells overexpressing gag-PKB displayed elevated levels of the antiapoptotic molecule Bcl-XL. In addition, the activation of peripheral T cells led to enhanced nuclear factor (NF)-κB activation via accelerated degradation of the NF-κB inhibitory protein IκBα. Our data highlight a physiological role for PKB in promoting survival of DP thymocytes and mature T cells, and provide evidence for the direct association of three major survival molecules (PKB, Bcl-XL, and NF-κB) in vivo in T lymphocytes.

scholarly journals Krüppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo

2007 ◽  
Vol 178 (9) ◽  
pp. 5496-5504 ◽  
Author(s):  
Meixia Zhou ◽  
Lisa McPherson ◽  
Dongdong Feng ◽  
An Song ◽  
Chen Dong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
T Lymphocyte ◽  
Lymphocyte Survival
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