Evidence for a role of oestrogen receptor-related receptor in the regulation of male sexual behaviour in the mothAgrotis ipsilon

2017 ◽  
Vol 26 (4) ◽  
pp. 403-413 ◽  
Author(s):  
F. Bozzolan ◽  
N. Durand ◽  
E. Demondion ◽  
T. Bourgeois ◽  
E. Gassias ◽  
...  
Keyword(s):  
Sexual Behaviour ◽  
Oestrogen Receptor ◽  
Male Sexual Behaviour

scholarly journals Oestrogen's masculine side: mediation of mating in male mice

Reproduction ◽  
2002 ◽  
pp. 331-338 ◽  
Author(s):  
EM Scordalakes ◽  
DB Imwalle ◽  
EF Rissman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Dopamine Agonist ◽  
Sexual Behaviour ◽  
Oestrogen Receptor ◽  
Neuronal Nitric Oxide Synthase ◽  
Receptor Alpha ◽  
Male Sexual Behaviour ◽  
Oestrogen Receptor Alpha ◽  
Oxide Synthase

This review focuses on the role of oestrogen in male sexual behaviour using oestrogen receptor alpha and beta knockout (ERalphaKO and ERbetaKO) mouse models. ERbetaKO mice are capable of mating and producing offspring, whereas ERalphaKO mice are unable to do either. When ERalphaKO males are treated with testosterone or dihydrotestosterone (DHT), < 50% display mounting behaviour, few intromit and none ejaculate. However, concurrent treatment with testosterone and a dopamine agonist instates masculine sexual behaviour in both male and female ERalphaKO mice. Dopamine content in the preoptic area and associated regions is not affected by oestrogen receptor alpha gene disruption. However, expression of neuronal nitric oxide synthase immunoreactivity is severely reduced in ERalphaKO males compared with wild-type males. These findings, together with studies conducted in aromatase knockout mice, are at odds with the dogma that oestrogen is required during development for expression of male sexual behaviour in adults. However, they do support a role for oestrogens, mediated by oestrogen receptor alpha, in regulation and production of neuronal nitric oxide synthase, which in turn may control dopamine agonist release. As has been shown in male rats, in mice dopamine agonist release is likely to be an essential component of the neural pathway that mediates male sexual behaviour.

The role of kisspeptin in the medial amygdala on male sexual behaviour in rats

2016 ◽  
Author(s):  
Rebecca Gresham ◽  
Shengyun Li Li ◽  
Daniel Adekunbi ◽  
Minghan Hu ◽  
Xiao Feng Li Li ◽  
...  
Keyword(s):  
Sexual Behaviour ◽  
Medial Amygdala ◽  
Male Sexual Behaviour

Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency

1999 ◽  
Vol 51 (4) ◽  
pp. 517-524 ◽  
Author(s):  
Cesare Carani ◽  
Vincenzo Rochira ◽  
Marco Faustini-Fustini ◽  
Antonio Balestrieri ◽  
Granata
Keyword(s):  
Sexual Behaviour ◽  
Male Sexual Behaviour

Male Sexual Behaviour: Further Studies on the Role of Alpha 2-Adrenoceptors

1993 ◽  
Vol 28 (1) ◽  
pp. 35-45 ◽  
Author(s):  
A. Benelli ◽  
R. Arletti ◽  
R. Basaglia ◽  
A. Bertolini
Keyword(s):  
Sexual Behaviour ◽  
Male Sexual Behaviour

A Method for Chronically Implanting Stimulating Electrodes into the Brains of Locusts, and some Results of Stimulation

1963 ◽  
Vol 40 (2) ◽  
pp. 271-284
Author(s):  
C. H. FRASER ROWELL
Keyword(s):  
Stainless Steel ◽  
Brain Stimulation ◽  
Sexual Behaviour ◽  
Foraging Behaviour ◽  
Stimulating Electrodes ◽  
The Brain ◽  
Antennal Movement ◽  
Steel Electrodes

1. Methods are described for implanting permanent stainless-steel electrodes into the brains of locusts, for stimulating the brain under near-normal conditions, and for localizing the electrode subsequently. 2. Threshold currents measured under these conditions are lower than those required in acute preparations, or if the animal is restrained. 3. The results of stimulation are described for four common aspects of behaviour. These are antennal movement, locomotion, feeding and sexual behaviour. 4. The effect of stimulation on antennal and locomotory movements largely confirms previous work on crickets. 5. Feeding and foraging behaviour, which is a very common result, is shown to be almost completely determined by peripheral stimuli at the time of brain stimulation. The role of the latter is permissive or disinhibitory rather than causal or excitatory. 6. Integrated sexual behaviour is occasionally inhibited, but never elicited, by stimulation. This contrasts with observations on crickets, and its implications are discussed.

scholarly journals Oestrogen receptors and antioestrogen treatment of hormone-dependent tumours

2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Sequences ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Specific Gene ◽  
Oestrogen Receptors ◽  
Human Breast ◽  
Potential Use

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.

scholarly journals The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer

2020 ◽  
Vol 16 (8) ◽  
pp. 1388-1402
Author(s):  
Wei Xu ◽  
Minghua Huang ◽  
Jia Guo ◽  
Huiting Zhang ◽  
Depeng Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
The Status

Male sexual behaviour not abolished after medial preoptic lesion in adult rats

Neuroreport ◽  
1996 ◽  
Vol 7 (9) ◽  
pp. 1481-1484 ◽  
Author(s):  
Velayudhan Mohan Kumar ◽  
Naseem Ahmad Khan ◽  
Joshi John
Keyword(s):  
Sexual Behaviour ◽  
Adult Rats ◽  
Male Sexual Behaviour

POSSIBLE INVOLVEMENT OF CYCLIC AMP IN REGULATION OF MASCULINE SEXUAL BEHAVIOUR BY TESTOSTERONE

1974 ◽  
Vol 61 (1) ◽  
pp. 153-161 ◽  
Author(s):  
L. W. CHRISTENSEN ◽  
L. G. CLEMENS
Keyword(s):  
Cyclic Amp ◽  
Sexual Behaviour ◽  
Adrenal Glands ◽  
Testosterone Propionate ◽  
Major Effect ◽  
Concurrent Administration ◽  
Adrenal Androgen ◽  
Mediating Role ◽  
Male Sexual Behaviour ◽  
Masculine Sexual Behaviour

SUMMARY Experiments were carried out to assess the possible involvement of cyclic AMP in the regulation of masculine sexual behaviour by testosterone in the laboratory rat. Doses of testosterone propionate which were ineffective in maintaining or inducing male sexual behaviour were potentiated by concurrent administration of theophylline. Since removal of the adrenal glands had no effect on this potentiation, the possibility that theophylline increased adrenal androgen secretion and thereby influenced sexual behaviour, can be ruled out. A major effect of theophylline is to increase levels of cyclic AMP by inhibiting the enzyme which inactivates this nucleotide. These results suggest that cyclic AMP may play a mediating role in the regulation of masculine sexual behaviour by testosterone.

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