scholarly journals Horizontal transmission of anR4clade non-long terminal repeat retrotransposon between the divergentAedesandAnophelesmosquito genera

2015 ◽  
Vol 24 (3) ◽  
pp. 331-337 ◽  
Author(s):  
J. K. Biedler ◽  
X. Chen ◽  
Z. Tu
Keyword(s):  
Long Terminal Repeat ◽  
Horizontal Transmission ◽  
Terminal Repeat ◽  
Long Terminal Repeat Retrotransposon

scholarly journals A novel discovery of a long terminal repeat retrotransposon-induced hybrid weakness in rice

2018 ◽  
Vol 70 (4) ◽  
pp. 1197-1207
Author(s):  
Sadia Nadir ◽  
Wei Li ◽  
Qian Zhu ◽  
Sehroon Khan ◽  
Xiao-Ling Zhang ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Long Terminal Repeat Retrotransposon ◽  
Hybrid Weakness

scholarly journals The L1Tc C-Terminal Domain from Trypanosoma cruzi Non-Long Terminal Repeat Retrotransposon Codes for a Protein That Bears Two C2H2 Zinc Finger Motifs and Is Endowed with Nucleic Acid Chaperone Activity

2005 ◽  
Vol 25 (21) ◽  
pp. 9209-9220 ◽  
Author(s):  
Sara R. Heras ◽  
Manuel C. López ◽  
José Luis García-Pérez ◽  
Sandra L. Martin ◽  
M. Carmen Thomas
Keyword(s):  
Nucleic Acid ◽  
Trypanosoma Cruzi ◽  
Long Terminal Repeat ◽  
Zinc Finger ◽  
Chaperone Activity ◽  
Terminal Repeat ◽  
Duplex Dna ◽  
Long Terminal Repeat Retrotransposon ◽  
Nucleic Acid Chaperone ◽  
Zinc Finger Motifs

ABSTRACT L1Tc, a non-long terminal repeat retrotransposon from Trypanosoma cruzi, is a 4.9-kb actively transcribed element which contains a single open reading frame coding for the machinery necessary for its autonomous retrotransposition. In this paper, we analyze the protein encoded by the L1Tc 3′ region, termed C2-L1Tc, which contains two zinc finger motifs similar to those present in the TFIIIA transcription factor family. C2-L1Tc binds nucleic acids with different affinities, such that RNA > tRNA > single-stranded DNA > double-stranded DNA, without any evidence for sequence specificity. C2-L1Tc also exhibits nucleic acid chaperone activity on different DNA templates that may participate in the mechanism of retrotransposition of the element. C2-L1Tc promotes annealing of complementary oligonucleotides, prevents melting of perfect DNA duplexes, and facilitates the strand exchange between DNAs to form the most stable duplex DNA in competitive displacement assays. Mapping of regions of C2-L1Tc using specific peptides showed that nucleic acid chaperone activity required a short basic sequence accompanied by a zinc finger motif or by another basic region such as RRR. Thus, a short basic polypeptide containing the two C2H2 motifs promotes formation of the most stable duplex DNA at a concentration only three times higher than that required for C2-L1Tc.

Gulliver, a long terminal repeat retrotransposon from the genome of the oriental blood fluke Schistosoma japonicum

Gene ◽  
2001 ◽  
Vol 264 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Thewarach Laha ◽  
Alex Loukas ◽  
Christiana K. Verity ◽  
Donald P. McManus ◽  
Paul J. Brindley
Keyword(s):  
Long Terminal Repeat ◽  
Schistosoma Japonicum ◽  
Terminal Repeat ◽  
Blood Fluke ◽  
Long Terminal Repeat Retrotransposon

pido , a non-long terminal repeat retrotransposon of the chicken repeat 1 family from the genome of the Oriental blood fluke, Schistosoma japonicum

Gene ◽  
2002 ◽  
Vol 284 (1-2) ◽  
pp. 149-159 ◽  
Author(s):  
Thewarach Laha ◽  
Paul J Brindley ◽  
Christiana K Verity ◽  
Donald P McManus ◽  
Alex Loukas
Keyword(s):  
Long Terminal Repeat ◽  
Schistosoma Japonicum ◽  
Terminal Repeat ◽  
Blood Fluke ◽  
Long Terminal Repeat Retrotransposon ◽  
Chicken Repeat

scholarly journals The MOV10 Helicase Inhibits LINE-1 Mobility

2013 ◽  
Vol 288 (29) ◽  
pp. 21148-21160 ◽  
Author(s):  
Xiaoyu Li ◽  
Jianyong Zhang ◽  
Rui Jia ◽  
Vicky Cheng ◽  
Xin Xu ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Genomic Dna ◽  
Rna Degradation ◽  
Terminal Repeat ◽  
Host Cells ◽  
Control Line ◽  
Helicase Activity ◽  
Long Terminal Repeat Retrotransposon ◽  
Cellular Control ◽  
Long Interspersed Element

LINE-1 (long interspersed element 1) is an autonomous non-long terminal repeat retrotransposon. Its replication often causes mutation and rearrangement of host genomic DNA. Accordingly, host cells have evolved mechanisms to control LINE-1 mobility. Here, we report that a helicase named MOV10 effectively suppresses LINE-1 transposition. Mutating the helicase motifs impairs this function of MOV10, suggesting that MOV10 requires its helicase activity to suppress LINE-1 replication. Further studies show that MOV10 post-transcriptionally diminishes the level of LINE-1 RNA. The association of MOV10 with both LINE-1 RNA and ORF1 suggests that MOV10 interacts with LINE-1 RNP and consequently causes its RNA degradation. These data demonstrate collectively that MOV10 contributes to the cellular control of LINE-1 replication.

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