Fesoterodine normalizes the brain function in overactive bladder patients due to central nervous system lesion: A real‐time measure of oxyhemoglobin concentration changes during urodynamics

2019 ◽  
Vol 26 (10) ◽  
pp. 1014-1015
Author(s):  
Ryuji Sakakibara ◽  
Fuyuki Tateno ◽  
Masashi Yano ◽  
Osamu Takahashi ◽  
Yosuke Aiba ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Overactive Bladder ◽  
Real Time ◽  
Brain Function ◽  
Central Nervous System Lesion ◽  
Concentration Changes ◽  
The Brain

Gut–brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: gut dysbiosis and altered brain function

2018 ◽  
Vol 94 (1114) ◽  
pp. 446-452 ◽  
Author(s):  
Borros M Arneth
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Well Being ◽  
Immune System Activation ◽  
Published Evidence ◽  
Bidirectional Communication ◽  
The Central Nervous System ◽  
Intestinal Functions ◽  
The Brain

BackgroundThe gut–brain axis facilitates a critical bidirectional link and communication between the brain and the gut. Recent studies have highlighted the significance of interactions in the gut–brain axis, with a particular focus on intestinal functions, the nervous system and the brain. Furthermore, researchers have examined the effects of the gut microbiome on mental health and psychiatric well-being.The present study reviewed published evidence to explore the concept of the gut–brain axis.AimsThis systematic review investigated the relationship between human brain function and the gut–brain axis.MethodsTo achieve these objectives, peer-reviewed articles on the gut–brain axis were identified in various electronic databases, including PubMed, MEDLINE, CIHAHL, Web of Science and PsycINFO.ResultsData obtained from previous studies showed that the gut–brain axis links various peripheral intestinal functions to brain centres through a broad range of processes and pathways, such as endocrine signalling and immune system activation. Researchers have found that the vagus nerve drives bidirectional communication between the various systems in the gut–brain axis. In humans, the signals are transmitted from the liminal environment to the central nervous system.ConclusionsThe communication that occurs in the gut–brain axis can alter brain function and trigger various psychiatric conditions, such as schizophrenia and depression. Thus, elucidation of the gut–brain axis is critical for the management of certain psychiatric and mental disorders.

Can irisin be a linker between physical activity and brain function?

2016 ◽  
Vol 7 (4) ◽  
pp. 253-258 ◽  
Author(s):  
Jing Zhang ◽  
Weizhen Zhang
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Function ◽  
Neural Differentiation ◽  
Pros And Cons ◽  
Differentiation And Proliferation ◽  
Neuronal Functions ◽  
The Brain

AbstractIrisin was initially discovered as a novel hormone-like myokine released from skeletal muscle during exercise to improve obesity and glucose dysfunction by stimulating the browning of white adipose tissue. Emerging evidence have indicated that irisin also affects brain function. FNDC5 mRNA and FNDC5/irisin immunoreactivity are present in various regions of the brain. Central irisin is involved in the regulation of neural differentiation and proliferation, neurobehavior, energy expenditure and cardiac function. Elevation of peripheral irisin level stimulates hippocampal genes related to neuroprotection, learning and memory. In this brief review, we summarize the current understanding on neuronal functions of irisin. In addition, we discuss the pros and cons for this molecule as a potential messenger mediating the crosstalk between skeletal muscle and central nervous system during exercise.

scholarly journals Brainwave assistive system for paralyzed individuals

2021 ◽  
Vol 2 (3) ◽  
pp. 79-89
Author(s):  
Md Ahnaf Shariar ◽  
Syeda Maliha Monowara ◽  
Md. Shafayat Ul Islam ◽  
Muhammed Junaid Noor Jawad ◽  
Saifur Rahman Sabuj
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Real Time ◽  
Brain Computer Interface ◽  
Computer Interface ◽  
Cursor Control ◽  
Eeg Data ◽  
The Central Nervous System ◽  
The Brain ◽  
Real Time Application

The Brain-Computer Interface (BCI) is a system based on brainwaves that can be used to translate and comprehend the innumerable activities of the brain. Brainwave refers to the bioelectric impulses invariably produced in the human brain during neurotransmission, often measured as the action potential. Moreover, BCI essentially uses the widely studied Electroencephalography (EEG) technique to capture brainwave data. Paralysis generally occurs when there is a disturbance in the central nervous system prompted by a neurodegenerative or unforeseen event. To overcome the obstacles associated with paralysis, this paper on the brainwave-assistive system is based on the BCI incorporated with Internet-of-things. BCI can be implemented to achieve control over external devices and applications. For instance, the process of cursor control, motor control, neuroprosthetics and wheelchair control, etc. In this paper, the OpenBCI Cyton-biosensing board has been used for the collection of the EEG data. The accumulated EEG data is executed subsequently to obtain control over the respective systems in real-time. Hence, it can be concluded that the experiments of the paper support the idea of controlling an interfaced system through the real-time application of EEG data.

scholarly journals Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

2018 ◽  
Vol 215 (6) ◽  
pp. 1627-1647 ◽  
Author(s):  
James C. Cronk ◽  
Anthony J. Filiano ◽  
Antoine Louveau ◽  
Ioana Marin ◽  
Rachel Marsh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Bone Marrow Transplantation ◽  
Brain Function ◽  
Cell Type ◽  
Cns Inflammation ◽  
Conditioning Regimens ◽  
The Brain

Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during central nervous system (CNS) inflammation. It was initially suggested that these engrafting cells were newly derived microglia and that irradiation was essential for engraftment to occur. However, it remains unclear whether brain-engrafting macrophages (beMφs) acquire a unique phenotype in the brain, whether long-term engraftment may occur without irradiation, and whether brain function is affected by the engrafted cells. In this study, we demonstrate that chronic, partial microglia depletion is sufficient for beMφs to populate the niche and that the presence of beMφs does not alter behavior. Furthermore, beMφs maintain a unique functional and transcriptional identity as compared with microglia. Overall, this study establishes beMφs as a unique CNS cell type and demonstrates that therapeutic engraftment of beMφs may be possible with irradiation-free conditioning regimens.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Complex Trauma and Prenatal Alcohol Exposure: Clinical Implications

2012 ◽  
Vol 13 (2) ◽  
pp. 32-42 ◽  
Author(s):  
Yvette D. Hyter
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Child Development ◽  
Academic Outcomes ◽  
Complex Trauma ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Clinical Implications ◽  
Prenatal Alcohol ◽  
The Brain

Abstract Complex trauma resulting from chronic maltreatment and prenatal alcohol exposure can significantly affect child development and academic outcomes. Children with histories of maltreatment and those with prenatal alcohol exposure exhibit remarkably similar central nervous system impairments. In this article, I will review the effects of each on the brain and discuss clinical implications for these populations of children.

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

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