scholarly journals Minimally invasive device for intravesical instillation by urological syringe adapter ( MID ‐ii U.S.A.) for catheter‐free instillation therapy of the bladder in interstitial cystitis/bladder pain syndrome

2019 ◽  
Vol 26 (S1) ◽  
pp. 57-60 ◽  
Author(s):  
Sandor Lovasz
Keyword(s):  
Minimally Invasive ◽  
Interstitial Cystitis ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Intravesical Instillation ◽  
Bladder Pain ◽  
Instillation Therapy ◽  
Invasive Device ◽  
Minimally Invasive Device

scholarly journals Pain Management in a Model of Interstitial Cystitis/Bladder Pain Syndrome by a Vaccinal Strategy

2021 ◽  
Vol 2 ◽  
Author(s):  
Céline Augé ◽  
Lilian Basso ◽  
Catherine Blanpied ◽  
Nathalie Vergnolle ◽  
Xavier Gamé ◽  
...  
Keyword(s):  
Pain Management ◽  
T Lymphocytes ◽  
Interstitial Cystitis ◽  
Visceral Pain ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Intravesical Instillation ◽  
T Cell Response ◽  
Vaccine Antigen ◽  
Bladder Pain

Current analgesic treatments for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) are limited. Here, we propose a novel antinociceptive strategy exploiting the opioid-mediated analgesic properties of T lymphocytes to relieve from bladder pain. In a chronic model of IC/BPS in rats, we show that a secondary T cell response against intravesically administered ovalbumin prevents from visceral pain in OVA-primed animals. The analgesic effect is associated with the recruitment of T lymphocytes within the inflamed mucosa and is reversed by naloxone-methiodide, a peripheral opioid receptor antagonist. Similarly, intravesical instillation of BCG or tetanus toxoid antigens in vaccinated rats protects from pain in the same model. We show opioid-dependent analgesic properties of local vaccine antigen recall in a preclinical rat model of chronic cystitis. Since BCG bladder instillation is regularly used in humans (as anticancer therapy), our results open it as a new therapeutic positioning for a pain management indication for IC/BPS patients.

Sign in / Sign up

Export Citation Format

Share Document