Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients

2018 ◽  
Vol 25 (7) ◽  
pp. 678-683 ◽  
Author(s):  
Yuta Inoue ◽  
Terukazu Nakamura ◽  
Hiroyuki Nakanishi ◽  
Masakatsu Oishi ◽  
Fumiya Hongo ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Myeloid Leukemia ◽  
Cell Tumor ◽  
Tumor Patients ◽  
Acute Myeloid

P072 Mediastinal germ cell tumor and acute myeloid leukemia

Blood Reviews ◽  
2007 ◽  
Vol 21 ◽  
pp. S109
Author(s):  
J. Csomor ◽  
J. Sinkó ◽  
Z. Sápi ◽  
E. Ráthonyi ◽  
B. Timár ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Myeloid Leukemia ◽  
Cell Tumor ◽  
Mediastinal Germ Cell Tumor ◽  
Acute Myeloid

scholarly journals GCT-56. ACUTE MYELOID LEUKEMIA FOLLOWING CHEMORADIOTHERAPY FOR INTRACRANIAL GERMINOMA: A CASE REPORT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii339-iii339
Author(s):  
Masato Nakaya ◽  
Yuya Koda ◽  
Kentaro Yamaguchi ◽  
Kazunari Yoshida ◽  
Hikaru Sasaki
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Fourth Ventricle ◽  
Myeloid Leukemia ◽  
Cell Tumor ◽  
Histopathological Diagnosis ◽  
Bleeding Tendency ◽  
Acute Myeloid

Abstract INTRODUCTION Therapy-related acute myeloid leukemia (t-AML) is known as　possible complication of chemotherapy, especially topoisomerase Ⅱ　inhibitor,　alkylating agents, and platinum agents. Although there are many reports of therapy-related leukemia associated with gonadal germ cell tumor, few cases have been reported on central nervous system (CNS) germ cell tumor. CASE REPORT: A 35-year old gentleman presented with diplopia. CT and MR imaging showed enhancing nodules on his right hypothalamus and around fourth ventricle, and differential diagnoses included sarcoidosis and germinoma. Biopsy for fourth ventricle lesion was performed via transvermian approach, and histopathological diagnosis was germinoma. He was treated by 3 cycles of CARE chemotherapy (carboplatin and etoposide) followed by craniospinal irradiation (CSI, 24Gy). After completion of chemoradiotherapy, he was followed up every half year by MRI, and there had been no evidence of tumor recurrence. Two years after chemoradiotherapy, however, the patient presented with bleeding tendency, which led to the diagnosis of AML. Based on the history of chemoradiotherapy and the presence of t(16;21)(q24; q22), t-AML was diagnosed. Complete remission was successfully achieved by chemotherapy consisting of idarubicin and cytarabine. DISCUSSION t-AML was diagnosed after chemoradiotherapy in a patient with CNS germinoma probably due to the administration of　topoisomerase II inhibitor, etoposide. The prognosis of t-AML is known to be poorer as compared with de novo AML. Therefore, intensive therapy such as allogeneic stem cell transplantation should be considered in younger patients. CONCLUSION A possibility of t-AML should be kept in mind following chemotherapy for CNS germ cell tumors.

scholarly journals Acute myeloid leukemia following a primary mediastinal germ cell tumor

2020 ◽  
Vol 4 (3) ◽  
pp. 218-221 ◽  
Author(s):  
Huimin Hong ◽  
Yan Su ◽  
Chenghao Chen ◽  
Lejian He ◽  
Shuai Zhu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Myeloid Leukemia ◽  
Cell Tumor ◽  
Mediastinal Germ Cell Tumor ◽  
Acute Myeloid

Chromosome abnormalities in a patient with acute myeloid leukemia following mediastinal germ cell tumor

1996 ◽  
Vol 91 (2) ◽  
pp. 175
Author(s):  
P. Scaravaglio ◽  
P. Facta ◽  
B. Ceresole ◽  
T. Guglielminetti ◽  
A. Berruti ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Myeloid Leukemia ◽  
Chromosome Abnormalities ◽  
Cell Tumor ◽  
Mediastinal Germ Cell Tumor ◽  
Acute Myeloid
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