Mesenchymal stem cell therapy in treatment of erectile dysfunction: Autologous or allogeneic cell sources?

2016 ◽  
Vol 23 (4) ◽  
pp. 348-349 ◽  
Author(s):  
Mustafa Kadihasanoglu ◽  
Emin Ozbek
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Allogeneic Cell ◽  
Cell Sources

Mesenchymal stem cell therapy in treatment of erectile dysfunction: Autologous or allogeneic cell sources?

2014 ◽  
Vol 21 (12) ◽  
pp. 1280-1285 ◽  
Author(s):  
Naside Mangir ◽  
Cem Akbal ◽  
Tufan Tarcan ◽  
Ferruh Simsek ◽  
Levent Turkeri
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Allogeneic Cell ◽  
Cell Sources

Mesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury

2019 ◽  
Vol 32 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Ömercan Albayrak ◽  
Tarık Emre Şener ◽  
Mehmet Erşahin ◽  
Suna Özbaş-Turan ◽  
Ceyda Ekentok ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Experimental Spinal Cord Injury ◽  
Cord Injury

Mesenchymal Stem Cell Therapy for the Treatment of Erectile Dysfunction

2015 ◽  
Vol 12 (5) ◽  
pp. 1105-1106 ◽  
Author(s):  
Mohit Khera ◽  
Maarten Albersen ◽  
John P. Mulhall
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Guan Qun Zhu ◽  
Seung Hwan Jeon ◽  
Woong Jin Bae ◽  
Sae Woong Choi ◽  
Hyun Cheol Jeong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Corpus Cavernosum ◽  
Low Energy ◽  
Control Group ◽  
Sprague Dawley ◽  
Mesenchymal Stem Cell Therapy

Background. Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy with MSCT and ESWT in a rat model of diabetic ED. Materials and Methods. Eight-week-old male Sprague-Dawley rats were randomly divided into 2 parts. Diabetic rats induced by streptozotocin (65 mg/kg) were randomly divided into 4 groups: (1) DM control group, (2) DM + ESWT group, (3) DM + MSCT group, and (4) DM + ESWT + MSCT group. The sham group was a normal control group (without streptozotocin). MSCT and (or) ESWT were, respectively, administered to each group according to the proposal for 8 weeks. Immediately after recording of intracavernous pressure (ICP), the penis was then harvested for histologic analysis, ELISA, and Western blotting. Results. The ratio of ICP/MAP was significantly higher in the DM + ESWT + MSCT group than in ESWT or MSCT treated group (P<0.05). Also, the treatment stimulated angiogenesis and vasodilatation in the corpus cavernosum (P<0.05). ESWT increased the quantity of MSCs in the corpus cavernosum and also induced MSCs to express more VEGF in vitro and vivo (P<0.05) which activated the PI3K/AKT/mTOR and NO/cGMP signaling pathways in the corpus cavernosum. The combination approach stimulated autophagy and decreased apoptosis in the corpus cavernosum. NGF and BDNF expressions were higher in the DM + ESWT + MSCT group than in the DM control group (P<0.01). Furthermore, the treatment promoted the MSC recruitment by inducing penile tissues to express more PECAM and SDF-1. Conclusions. Combination of LI-ESWT and MSCT can get a better result than a single treatment by expressing more VEGF which can take part in autophagy by triggering the PI3K/AKT/mTOR signaling pathway. This cooperative therapy would provide a new research direction in ED treatment for the future.

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