scholarly journals Targeting Aspirin in Acute Disabling Ischemic Stroke: An Individual Patient Data Meta-Analysis of Three Large Randomized Trials

2015 ◽  
Vol 10 (7) ◽  
pp. 1024-1030 ◽  
Author(s):  
Douglas D. Thompson ◽  
Gordon D. Murray ◽  
Livia Candelise ◽  
Zhengming Chen ◽  
Peter A. G. Sandercock ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data

scholarly journals Age and organ damage correlate with poor survival in myeloma patients: meta-analysis of 1435 individual patient data from 4 randomized trials

Haematologica ◽  
2013 ◽  
Vol 98 (6) ◽  
pp. 980-987 ◽  
Author(s):  
S. Bringhen ◽  
M. V. Mateos ◽  
S. Zweegman ◽  
A. Larocca ◽  
A. P. Falcone ◽  
...  
Keyword(s):  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Organ Damage ◽  
Patient Data ◽  
Poor Survival

Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials

2016 ◽  
Vol 194 (6) ◽  
pp. 681-691 ◽  
Author(s):  
Jason A. Roberts ◽  
Mohd-Hafiz Abdul-Aziz ◽  
Joshua S. Davis ◽  
Joel M. Dulhunty ◽  
Menino O. Cotta ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data

scholarly journals Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials

2008 ◽  
Vol 26 (35) ◽  
pp. 5802-5812 ◽  
Keyword(s):  
Cervical Cancer ◽  
Survival Benefit ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Late Toxicity ◽  
Tumor Stage ◽  
Distant Recurrence ◽  
Patient Data

BackgroundAfter a 1999 National Cancer Institute (NCI) clinical alert was issued, chemoradiotherapy has become widely used in treating women with cervical cancer. Two subsequent systematic reviews found that interpretation of the benefits was complicated, and some important clinical questions were unanswered.Patients and MethodsWe initiated a meta-analysis seeking updated individual patient data from all randomized trials to assess the effect of chemoradiotherapy on all outcomes. We prespecified analyses to investigate whether the effect of chemoradiotherapy differed by trial or patient characteristics.ResultsOn the basis of 13 trials that compared chemoradiotherapy versus the same radiotherapy, there was a 6% improvement in 5-year survival with chemoradiotherapy (hazard ratio [HR] = 0.81, P < .001). A larger survival benefit was seen for the two trials in which chemotherapy was administered after chemoradiotherapy. There was a significant survival benefit for both the group of trials that used platinum-based (HR = 0.83, P = .017) and non–platinum-based (HR = 0.77, P = .009) chemoradiotherapy, but no evidence of a difference in the size of the benefit by radiotherapy or chemotherapy dose or scheduling was seen. Chemoradiotherapy also reduced local and distant recurrence and progression and improved disease-free survival. There was a suggestion of a difference in the size of the survival benefit with tumor stage, but not across other patient subgroups. Acute hematologic and GI toxicity was increased with chemoradiotherapy, but data were too sparse for an analysis of late toxicity.ConclusionThese results endorse the recommendations of the NCI alert, but also demonstrate their applicability to all women and a benefit of non–platinum-based chemoradiotherapy. Furthermore, although these results suggest an additional benefit from adjuvant chemotherapy, this requires testing in randomized trials.

scholarly journals Inhaled Nitric Oxide in Preterm Infants: An Individual-Patient Data Meta-analysis of Randomized Trials

PEDIATRICS ◽  
2011 ◽  
Vol 128 (4) ◽  
pp. 729-739 ◽  
Author(s):  
L. M. Askie ◽  
R. A. Ballard ◽  
G. R. Cutter ◽  
C. Dani ◽  
D. Elbourne ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Preterm Infants ◽  
Randomized Trials ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Inhaled Nitric Oxide
Sign in / Sign up

Export Citation Format

Share Document