Intravenous Thrombolytic Therapy for Acute Ischemic Stroke in Tuzla Canton, Bosnia and Herzegovina

2013 ◽  
Vol 8 (7) ◽  
pp. E48-E48
Author(s):  
Dževdet Smajlović ◽  
Denisa Salihović ◽  
Leila Avdić ◽  
Zikrija Dostović ◽  
Omer Ć. Ibrahimagić ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Bosnia And Herzegovina

scholarly journals Experiences of Thrombolytic Therapy for Ischemic Stroke in Tuzla Canton, Bosnia and Herzegovina

ISRN Stroke ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Dževdet Smajlović ◽  
Denisa Salihović ◽  
Omer Ć. Ibrahimagić ◽  
Zikrija Dostović ◽  
Leila Avdić ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Bosnia And Herzegovina ◽  
Developed Countries ◽  
Stroke Severity ◽  
Large Artery ◽  
Stroke Risk Factor ◽  
Number Of Patients ◽  
The Mean

Aim. To demonstrate our experiences of thrombolytic therapy in acute ischemic stroke. Subjects and Methods. Patients with ischemic stroke treated with rt-PA, admitted at the Department of Neurology, Tuzla, Bosnia and Herzegovina, in the period between April 1, 2008, and December 31, 2012, were included. Results. Between April 2008 and December 2012, intravenous rt-PA was given to 87 patients with acute ischemic stroke, which represents 3.2% of patients with acute ischemic stroke admitted to our department in that period. Hypertension was the leading stroke risk factor. The mean NIHSS score before thrombolysis was 12 (range 4–21). Large artery arteriosclerosis was the most common stroke etiology. The mean door-to-needle time was 72 minutes and onset-to-needle time 152 minutes. Half of patients (44/87) had a significant improvement within the first 24 hours. Parenchymal hemorrhage occurred in 5 patients (6%) and was fatal in two cases. At 3-month follow-up, 45% of patients (39/87) had good outcome (mRS 0 or 1). Sixteen patients were dead at 3 months, and mean baseline stroke severity was significantly higher in patients who died (NIHSS 16.5 versus 11, P=0.003). Conclusion. The number of patients with acute ischemic stroke treated using rt-PA in the Department of Neurology, Tuzla, is lower than in developed countries. Thrombolytic therapy is safe and leads to favorable outcome in half of the patients.

scholarly journals Outcomes of Thrombolytic Therapy for Acute Ischemic Stroke in Chinese Patients

Stroke ◽  
2010 ◽  
Vol 41 (5) ◽  
pp. 885-890 ◽  
Author(s):  
A-Ching Chao ◽  
Hung-Yi Hsu ◽  
Chih-Ping Chung ◽  
Chung-Hsiang Liu ◽  
Chih-Hung Chen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Chinese Patients

scholarly journals A Description of Canadian and United States Physician Reimbursement for Thrombolytic Therapy Administration in Acute Ischemic Stroke

Stroke ◽  
2005 ◽  
Vol 36 (3) ◽  
pp. 682-687 ◽  
Author(s):  
Dawn Kleindorfer ◽  
Michael D. Hill ◽  
Daniel Woo ◽  
Thomas Tomsick ◽  
Arthur Pancioli ◽  
...  
Keyword(s):  
United States ◽  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Physician Reimbursement

Comparative Analysis on Low- and Standard-Dose Regimes of Alteplase Thrombolytic Therapy for Acute Ischemic Stroke: Efficacy and Safety

2017 ◽  
Vol 79 (1-2) ◽  
pp. 68-73 ◽  
Author(s):  
Guangjian Zhao ◽  
Tingfen Huang ◽  
Mei Zheng ◽  
Yansen Cui ◽  
Yunyong Liu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke ◽  
Dose Group ◽  
Low Dose ◽  
Standard Dose ◽  
Efficacy And Safety ◽  
Significant Difference ◽  
Symptomatic Intracranial Hemorrhage ◽  
Intravenous Alteplase

Objective: This study analyzed the efficacy and safety of low-dose and standard-dose alteplase intravenous thrombolytic therapy for acute ischemic stroke (AIS). Methods: Patients with AIS who underwent intravenous alteplase thrombolysis from July 2012 to December 2016 were retrospectively analyzed and correspondingly divided into low-dose (0.6–0.89 mg/kg) group and standard-dose group (0.9 mg/kg) according to alteplase dosage. The clinical outcome was evaluated by modified Rankin Scale (mRS) at 90 days after onset. The safety index was the mortality at 90 days after onset and the incidence of symptomatic intracranial hemorrhage (SICH) within 7 days. Results: A total of 1,486 patients were included (1,115 cases in low-dose group and 371 cases in standard-dose group). There were no significant differences in baseline data between the 2 groups. As mRS, good outcome rate as well as mortality rate in both groups had no significant difference (36.1 vs. 37.6%; χ2 = 10.882, p = 0.890; 5.5 vs. 7.3%; χ2 = 2.163, p = 0.076), but the incidence of SICH in low-dose group was significantly lower than that of the standard-dose group (2.2 vs. 5.9%; χ2 = 3.157, p = 0.001). Conclusion: The efficacy of low-dose alteplase intravenous thrombolytic therapy for AIS was equivalent to the standard-dose regimen but with higher safety.

Drip and Ship Thrombolytic Therapy for Acute Ischemic Stroke

Stroke ◽  
2015 ◽  
Vol 46 (3) ◽  
pp. 732-739 ◽  
Author(s):  
Kevin N. Sheth ◽  
Eric E. Smith ◽  
Maria V. Grau-Sepulveda ◽  
Dawn Kleindorfer ◽  
Gregg C. Fonarow ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Acute Ischemic Stroke
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