scholarly journals Genome‐wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study

2020 ◽  
Author(s):  
Victoria L Buchanan ◽  
Yujie Wang ◽  
Estela Blanco ◽  
Mariaelisa Graff ◽  
Cecilia Albala ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Allelic Heterogeneity ◽  
Fasting Insulin ◽  
Genome Wide ◽  
Novel Variant

scholarly journals FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study

Diabetologia ◽  
2018 ◽  
Vol 61 (5) ◽  
pp. 1112-1123 ◽  
Author(s):  
Veroniqa Lundbäck ◽  
Agne Kulyte ◽  
Rona J. Strawbridge ◽  
Mikael Ryden ◽  
Peter Arner ◽  
...  
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Fasting Insulin ◽  
Genome Wide ◽  
A Genome

scholarly journals Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Robert Løvsletten Smith ◽  
Kevin O’Connell ◽  
Lavinia Athanasiu ◽  
Srdjan Djurovic ◽  
Marianne Kristiansen Kringen ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Smoking Habits ◽  
Serum Concentrations ◽  
Genome Wide ◽  
A Genome ◽  
Increased Risk ◽  
Novel Variant

Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum concentration adjusting for known smoking habits, which is a major nongenetic factor reducing CLZ levels. The study included 484 patients with 10,283 steady-state serum concentrations of CLZ and N-desmethylclozapine, prescribed dosing, co-medications and known smoking habits (n = 422; 9284 serum samples) from a therapeutic drug monitoring (TDM) service. The GWAS analyses were performed with and without smoking habits as covariate, where possible hits were assessed in relation to the target CLZ concentration range applied in the TDM service (300–2500 nmol/L). The smoking-independent analysis of N-desmethylclozapine serum concentration and the CLZ-to-N-desmethylclozapine ratio replicated the previously identified locus on chromosome 4. After adjusting for smoking habits in patients confirmed as ‘smokers’ (61%) or ‘nonsmokers’ (39%), a novel variant (rs28379954; minor T>C allele frequency 4.1%; 7.6% CT carriers in the population) within the gene encoding the nuclear factor 1 B-type (NFIB) was significantly associated with reduced CLZ serum concentration (p = 1.68 × 10−8, beta = −0.376; explained variance 7.63%). There was no significant association between rs28379954 and N-desmethylclozapine concentration in the GWAS analysis (p = 5.63 × 10−5). The fraction of CLZ TDM samples below 300 nmol/L was significantly higher in carriers vs. noncarriers of the rs28379954 minor C allele [12.0% (95% CI: 9.4–14.7) vs. 6.2% (95% CI: 5.7–6.8), p < 0.001]. We identified a novel variant in the NFIB gene associated with reduced CLZ levels and increased risk of subtherapeutic serum concentrations. This warrants testing of clinical relevance of screening for this gene variant, and also experimental studies to investigate the biological mechanisms of NFIB involvement in CLZ pharmacokinetics.

scholarly journals Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans

2012 ◽  
Vol 21 (20) ◽  
pp. 4530-4536 ◽  
Author(s):  
Guanjie Chen ◽  
Amy Bentley ◽  
Adebowale Adeyemo ◽  
Daniel Shriner ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
African Americans ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Fasting Insulin ◽  
Genome Wide

Genome wide association study on memory in schizophrenia patients and unaffected probands

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
B Konte ◽  
I Giegling ◽  
AM Hartmann ◽  
H Konnerth ◽  
P Muglia ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide
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