scholarly journals Liraglutide effects in a paediatric (7‐11 y) population with obesity: A randomized, double‐blind, placebo‐controlled, short‐term trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics

2019 ◽  
Vol 14 (5) ◽  
pp. e12495 ◽  
Author(s):  
Lucy D. Mastrandrea ◽  
Louise Witten ◽  
Kristin C. Carlsson Petri ◽  
Paula M. Hale ◽  
Hanna K. Hedman ◽  
...  
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Short Term Trial ◽  
Term Trial

Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome☆

2005 ◽  
Vol 6 (2) ◽  
pp. 141-147 ◽  
Author(s):  
D.L. Bliwise ◽  
A. Freeman ◽  
C.D. Ingram ◽  
D.B. Rye ◽  
S. Chakravorty ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Restless Legs ◽  
Short Term Trial ◽  
Term Trial

Diclofenac Sodium (Voltaren): Results of a Multi-Centre Comparative Trial in Adult-Onset Rheumatoid Arthritis

1975 ◽  
Vol 3 (3) ◽  
pp. 139-144 ◽  
Author(s):  
T Dürrigl ◽  
M Vitaus ◽  
I Pucar ◽  
M Miko
Keyword(s):  
Rheumatoid Arthritis ◽  
Urine Analysis ◽  
Diclofenac Sodium ◽  
Comparative Trial ◽  
Blood Picture ◽  
Short Term ◽  
Double Blind ◽  
Short Term Trial ◽  
Term Trial ◽  
Clinically Significant

A short-term trial has been performed under double-blind conditions in 50 adult patients with rheumatoid arthritis to compare diclofenac sodium (Voltaren) with both indomethacin and placebo for efficacy and tolerability. The duration of the trial was two weeks and was a between-patient comparison of 25 mg t.i.d. diclofenac sodium, 25 mg t.i.d. indomethacin or placebo using a double-dummy technique. Forty-eight patients completed the trial. In the majority of parameters examined, diclofenac sodium was superior to placebo and indomethacin in therapeutic effect. One patient was withdrawn from the trial because of intolerance to indomethacin and one other because of severe joint pain under indomethacin therapy. Neither active compound caused clinically significant changes in blood picture or urine analysis.

Randomized, double-blind, short-term trial of nabumetone versus diclofenac in osteoarthritis of the knee

1992 ◽  
Vol 52 (4) ◽  
pp. 581-586 ◽  
Author(s):  
Suliman R. Alballa ◽  
Hussein Al-Arfaj ◽  
Saleh Al-Sugair ◽  
Abdurhman Al-Arfaj ◽  
Sulaiman A. Al-Shammari
Keyword(s):  
Osteoarthritis Of The Knee ◽  
Short Term ◽  
Double Blind ◽  
Short Term Trial ◽  
Term Trial

DOUBLE-BLIND SHORT-TERM TRIAL OF FURAZOLIDONE IN PEPTIC ULCER

The Lancet ◽  
1985 ◽  
Vol 325 (8436) ◽  
pp. 1048-1049 ◽  
Author(s):  
Zheng Zhi-Tian ◽  
Wang Zheng-Ying ◽  
Chu Ya-Xian ◽  
Li Yi-Nung ◽  
Li Qiong-Fang ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Short Term ◽  
Double Blind ◽  
Short Term Trial ◽  
Term Trial

Lack of effects of transdermal estradiol on diastolic function: a randomized placebo-controlled double-blind short-term trial

Climacteric ◽  
1999 ◽  
Vol 2 (3) ◽  
pp. 174-180 ◽  
Author(s):  
E. Z. Fisman ◽  
A. Tenenbaum ◽  
I. Shapira ◽  
M. Motro ◽  
A. Pines
Keyword(s):  
Diastolic Function ◽  
Short Term ◽  
Double Blind ◽  
Short Term Trial ◽  
Term Trial ◽  
Transdermal Estradiol

scholarly journals Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2014 ◽  
Vol 99 (6) ◽  
pp. E1088-E1096 ◽  
Author(s):  
Christian Høst ◽  
Lars C. Gormsen ◽  
David M. Hougaard ◽  
Jens S. Christiansen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
High Molecular Weight ◽  
Glucose Disposal ◽  
Short Term ◽  
High Molecular Weight Adiponectin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

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