Preliminary investigation of the feasibility of a long‐term but low‐frequency preventive intervention for depression in Japanese high schools

Author(s):  
Kohei Kambara ◽  
Yugo Kira ◽  
Risa Kohno ◽  
Akiko Ogata
2011 ◽  
Author(s):  
Nicole E. Mahrer ◽  
Colleen M. Carr ◽  
Sharlene A. Wolchik ◽  
Irwin N. Sandler ◽  
Jenn-Yun Tein

2014 ◽  
Vol 7 (6) ◽  
pp. 914-916 ◽  
Author(s):  
Didier Clarençon ◽  
Sonia Pellissier ◽  
Valérie Sinniger ◽  
Astrid Kibleur ◽  
Dominique Hoffman ◽  
...  

1991 ◽  
Vol 65 (1) ◽  
pp. 20-32 ◽  
Author(s):  
Y. Komatsu ◽  
S. Nakajima ◽  
K. Toyama

1. Intracellular recording was made from layer II-III cells in slice preparations of kitten (30-40 days old) visual cortex. Low-frequency (0.1 Hz) stimulation of white matter (WM) usually evoked an excitatory postsynaptic potential (EPSP) followed by an inhibitory postsynaptic potential (IPSP). The postsynaptic potentials (PSPs) showed strong dependence on stimulus frequency. Early component of EPSP and IPSP evoked by weak stimulation both decreased monotonically at frequencies greater than 0.5-1 Hz. Strong stimulation similarly depressed the early EPSP at higher frequencies (greater than 2 Hz) and replaced the IPSP with a late EPSP, which had a maximum amplitude in the stimulus frequency range of 2-5 Hz. 2. Very weak WM stimulation sometimes evoked EPSPs in isolation from IPSPs. The falling phase of the EPSP revealed voltage dependence characteristic to the responses mediated by N-methyl-D-aspartate (NMDA) receptors and was depressed by application of an NMDA antagonist DL-2-amino-5-phosphonovalerate (APV), whereas the rising phase of the EPSP was insensitive to APV. 3. The early EPSPs followed by IPSPs were insensitive to APV but were replaced with a slow depolarizing potential by application of a non-NMDA antagonist 6,7-dinitro-quinoxaline-2,3-dione (DNQX), indicating that the early EPSP is mediated by non-NMDA receptors. The slow depolarization was mediated by NMDA receptors because it was depressed by membrane hyperpolarization or addition of APV. 4. The late EPSP evoked by higher-frequency stimulation was abolished by APV, indicating that it is mediated by NMDA receptors, which are located either on the recorded cell or on presynaptic cells to the recorded cells. 5. Long-term potentiation (LTP) of EPSPs was examined in cells perfused with solutions containing 1 microM bicuculline methiodide (BIM), a gamma-aminobutyric acid (GABA) antagonist. WM was stimulated at 2 Hz for 15 min as a conditioning stimulus to induce LTP, and the resultant changes were tested by low-frequency (0.1 Hz) stimulation of WM. 6. LTP of early EPSPs occurred in more than one-half of the cells (8/13) after strong conditioning stimulation. The rising slope of the EPSP was increased 1.6 times on average. 7. To test involvement of NMDA receptors in the induction of LTP in the early EPSP, the effect of conditioning stimulation was studied in a solution containing 100 microM APV, which was sufficient to block completely synaptic transmission mediated by NMDA receptors. LTP occurred in the same frequency and magnitude as in control solution.


2008 ◽  
Vol 21 (9) ◽  
pp. 1948-1962 ◽  
Author(s):  
R. Garcia-Herrera ◽  
D. Barriopedro ◽  
E. Hernández ◽  
H. F. Diaz ◽  
R. R. Garcia ◽  
...  

Abstract The authors present a chronology of El Niño (EN) events based on documentary records from northern Peru. The chronology, which covers the period 1550–1900, is constructed mainly from primary sources from the city of Trujillo (Peru), the Archivo General de Indias in Seville (Spain), and the Archivo General de la Nación in Lima (Peru), supplemented by a reassessment of documentary evidence included in previously published literature. The archive in Trujillo has never been systematically evaluated for information related to the occurrence of El Niño–Southern Oscillation (ENSO). Abundant rainfall and river discharge correlate well with EN events in the area around Trujillo, which is very dry during most other years. Thus, rain and flooding descriptors, together with reports of failure of the local fishery, are the main indicators of EN occurrence that the authors have searched for in the documents. A total of 59 EN years are identified in this work. This chronology is compared with the two main previous documentary EN chronologies and with ENSO indicators derived from proxy data other than documentary sources. Overall, the seventeenth century appears to be the least active EN period, while the 1620s, 1720s, 1810s, and 1870s are the most active decades. The results herein reveal long-term fluctuations in warm ENSO activity that compare reasonably well with low-frequency variability deduced from other proxy data.


Author(s):  
Neil Bates ◽  
David Lee ◽  
Clifford Maier

This paper describes case studies involving crack detection in-line inspections and fitness for service assessments that were performed based on the inspection data. The assessments were used to evaluate the immediate integrity of the pipeline based on the reported features and the long-term integrity of the pipeline based on excavation data and probabilistic SCC and fatigue crack growth simulations. Two different case studies are analyzed, which illustrate how the data from an ultrasonic crack tool inspection was used to assess threats such as low frequency electrical resistance weld seam defects and stress corrosion cracking. Specific issues, such as probability of detection/identification and the length/depth accuracy of the tool, were evaluated to determine the suitability of the tool to accurately classify and size different types of defects. The long term assessment is based on the Monte Carlo method [1], where the material properties, pipeline details, crack growth parameters, and feature dimensions are randomly selected from certain specified probability distributions to determine the probability of failure versus time for the pipeline segment. The distributions of unreported crack-related features from the excavation program are used to distribute unreported features along the pipeline. Simulated crack growth by fatigue, SCC, or a combination of the two is performed until failure by either leak or rupture is predicted. The probability of failure calculation is performed through a number of crack growth simulations for each of the reported and unreported features and tallying their respective remaining lives. The results of the probabilistic analysis were used to determine the most effective and economical means of remediation by identifying areas or crack mechanisms that contribute most to the probability of failure.


2009 ◽  
Vol 136 (5) ◽  
pp. A-20
Author(s):  
Judith E. Baars ◽  
Ernst J. Kuipers ◽  
Ruud Beukers ◽  
Adriaan C. Tan ◽  
Bas L. Weusten ◽  
...  

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