scholarly journals Chlorhexidine gluconate transparent dressing does not decrease central line‐associated bloodstream infection in critically ill patients: A randomized controlled trial

2019 ◽  
Vol 25 (6) ◽  
Author(s):  
Kunrong Yu ◽  
Meishan Lu ◽  
Yanling Meng ◽  
Yanwei Zhao ◽  
Zheng Li
Keyword(s):  
Randomized Controlled Trial ◽  
Bloodstream Infection ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Central Line ◽  
Chlorhexidine Gluconate ◽  
Randomized Controlled

Comparison of chlorhexidine impregnated dressing and standard dressing for the prevention of central-line associated blood stream infection and colonization in Critically Ill Pediatric Patients: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Muhterem Duyu ◽  
Zeynep Karakaya ◽  
Pinar Yazici ◽  
Senanur Yavuz ◽  
Nihal Meryem Yersel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bloodstream Infection ◽  
Critically Ill ◽  
Pediatric Patients ◽  
Blood Stream Infection ◽  
Controlled Trial ◽  
Central Line ◽  
Blood Product Transfusion ◽  
Catheter Colonization ◽  
Randomized Controlled

Abstract Objective: The purpose of this study is to compare chlorhexidine gluconate (CHG)-impregnated dressing and standard dressing with respect to their effects on the frequency of central-line associated bloodstream infection (CLABSI), catheter related bloodstream infection (CRBSI), primary bloodstream infection (BSI) and catheter colonization in critically ill pediatric patients with short-term central venous catheter.Methods: Prospective, single-center randomized controlled trial performed in pediatric intensive care unit (PICU) of a tertiary referral hospital. The patients were randomized with respect to the type of catheter fixation they had received, either with CHG-impregnated dressing or standard dressing.Results: A total of 307 patients (151 CHG-impregnated dressing, 156 standard dressing), with 307 catheters amounting to a collective total of 4993 catheter days, were included in the study. Use of CHG impregnated dressing did not significantly decrease the incidence of CLABSI (6.36 per 1000 catheter days vs. 7.59 per 1000 catheter days; HR: 0.93, P = 0.76), CRBSI (3.82 per 1000 catheter days vs. 4.18 per 1000 catheter days; HR: 0.98, P = 0.98), primary BSI (2.54 per 1000 catheter days vs. 3.42 catheter days; HR: 0.39, P = 0.67). CHG-impregnated dressing significantly decreased the incidence of catheter colonization (3.82 per 1000 catheter days vs. 7.59 per 1000 catheter days; HR: 0.40, P = 0.04). Longer catheter time-in-place and use of blood product transfusion were found to be independently associated with CLABSI.Conclusions: The use of CHG-impregnated dressing does not significantly decrease CLABSI incidence in critically ill pediatric patients compared to standard dressing, but it is effective in reducing catheter colonization.

scholarly journals Full versus Trophic Feeds in Critically Ill Adults with High and Low Nutritional Risk Scores: A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3518
Author(s):  
Chen-Yu Wang ◽  
Pin-Kuei Fu ◽  
Wen-Cheng Chao ◽  
Wei-Ning Wang ◽  
Chao-Hsiu Chen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Hospital Stay ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Risk Scores ◽  
Nutrition Risk ◽  
Randomized Controlled ◽  
Trophic Feeding

Although energy intake might be associated with clinical outcomes in critically ill patients, it remains unclear whether full or trophic feeding is suitable for critically ill patients with high or low nutrition risk. We conducted a prospective study to determine which feeding energy intakes were associated with clinical outcomes in critically ill patients with high or low nutrition risk. This was an investigator-initiated, single center, single blind, randomized controlled trial. Critically ill patients were allocated to either high or low nutrition risk based on their Nutrition Risk in the Critically Ill score, and then randomized to receive either the full or the trophic feeding. The feeding procedure was administered for six days. No significant differences were observed in hospital, 14-day and 28-day mortalities, the length of ventilator dependency, or ICU and hospital stay among the four groups. There were no associations between energy and protein intakes and hospital, 14-day and 28-day mortalities in any of the four groups. However, protein intake was positively associated with the length of hospital stay and ventilator dependency in patients with low nutrition risk receiving trophic feeding. Full or trophic feeding in critically ill patients showed no associations with clinical outcomes, regardless of nutrition risk.

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