Managing cancer-related fatigue in men with prostate cancer: A systematic review of non-pharmacological interventions

2013 ◽  
Vol 20 (5) ◽  
pp. 549-560 ◽  
Author(s):  
David Larkin ◽  
Violeta Lopez ◽  
Edoardo Aromataris
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue

scholarly journals Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3750
Author(s):  
Felice Crocetto ◽  
Erika di Zazzo ◽  
Carlo Buonerba ◽  
Achille Aveta ◽  
Savio Domenico Pandolfo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Bladder Cancer ◽  
Clinical Trials ◽  
Epidemiological Studies ◽  
Pharmacological Interventions ◽  
Anti Cancer ◽  
High Prevalence ◽  
Prolonged Latency ◽  
Potential Use

Prostate and bladder cancer represent the two most frequently diagnosed genito-urinary malignancies. Diet has been implicated in both prostate and bladder cancer. Given their prolonged latency and high prevalence rates, both prostate and bladder cancer represent attractive candidates for dietary preventive measures, including the use of nutritional supplements. Flavonols, a class of flavonoids, are commonly found in fruit and vegetables and are known for their protective effect against diabetes and cardiovascular diseases. Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies. In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer. A total of 21, 15 and 7 pre-clinical articles on bladder or prostate cancer reporting on kaempferol, fisetin and myricetin, respectively, were found, while more limited evidence was available from animal models and epidemiological studies or clinical trials. In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.

scholarly journals Pharmacological Interventions for the Management of Cancer-Related Fatigue Among Cancer Survivors: Systematic Review and Meta-Analysis

2021 ◽  
Vol 20 ◽  
pp. 153473542110380
Author(s):  
Xuemei Sun ◽  
Yancong Chen ◽  
William KW Cheung ◽  
Irene XY Wu ◽  
Fang Xiao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Cancer Survivors ◽  
Meta Analysis ◽  
Random Effect ◽  
Minimal Important Difference ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue

Objective: Current guidelines have different recommendations on applying pharmacological interventions for managing cancer-related fatigue (CRF) among cancer survivors. This systematic review aims to synthesize clinical evidence on pharmacological interventions for managing CRF. Methods: Five databases were searched for potential randomized controlled trials (RCTs) from their inception until October 2020. RCTs assessing the effect of pharmacological treatments for CRF among cancer survivors were considered eligible. Clinical significance was determined by comparing the estimated effect with that of minimal important difference (MID). The risk of bias of each included RCT was appraised using the Cochrane risk of bias tool for randomized trials 2. Data were synthesized using random-effect pairwise meta-analyses. Results: A total of 15 RCTs (1238 participants) were included. The majority presented some concerns of bias arising from the randomization process and selection of the reported results. Meta-analysis showed that psychostimulant and wakefulness agents had statistically significant while clinically insignificant effects on the treatment of CRF (pooled weighted mean difference [WMD]: 2.8, 95% confidence interval [CI]: 0.2-5.4, I2: 0%, 3 RCTs, MID: 3.0-6.0). Three natural products, including Renshen Yangrong Tang (mean difference [MD]: −16.1, 95% CI: −8.9 to −23.3, MID: −17.3 to −11.4), Tualang honey (MD: 11.2, 95% CI: 7.1-15.3, MID: 3.0-6.0), and Shenmai injection plus Peptisorb (MD: −1.6, 95% CI: −2.1 to −1.1, MID: −1.1 to −0.8) demonstrated statistically and clinically significant effect in reducing CRF. Conclusions: Existing evidence showed promising effects of 3 natural products in reducing CRF among cancer survivors. The results from this study need to be further confirmed with well-designed and adequately powered RCTs that use validated instruments for the measurement of CRF.

Exercise for the Management of Cancer-Related Fatigue (DRAFT)

2018 ◽  
Author(s):  
Lynn A. Flint ◽  
Eric Widera
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Resistance Training ◽  
Physical Exercise ◽  
Aerobic Exercise ◽  
Meta Analysis ◽  
Cancer Related Fatigue ◽  
Breast And Prostate Cancer ◽  
Type Of Exercise ◽  
The Relationship

The report described here is a systematic review and meta-analysis of 28 studies examining the relationship between physical exercise and cancer-related fatigue in adults with cancer. Overall, exercise was associated with improvements in cancer-related fatigue both during and after treatment. The data was most robust for patients with breast and prostate cancer. Aerobic exercise was the only specific type of exercise associated with an improvement in fatigue. Further study is needed to determine whether other types of exercise, such as resistance training and mind-body exercises like yoga, impact cancer-related fatigue. Further study would clarify whether exercise is associated with improvements in cancer-related fatigue for patients with malignancies other than breast or prostate cancer.

A systematic review of systematic reviews and pooled meta-analysis on pharmacological interventions to improve cancer-related fatigue

2021 ◽  
pp. 103373
Author(s):  
Silvia Belloni ◽  
Cristina Arrigoni ◽  
Rita de Sanctis ◽  
Marco Alfredo Arcidiacono ◽  
Federica Dellafiore ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue
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