Hemophagocytic histiocytosis in severe SARS‐CoV‐2 infection: A bone marrow study

Bone marrow study

Annals of Emergency Medicine ◽

10.1016/s0196-0644(89)80042-3 ◽

1989 ◽

Vol 18 (7) ◽

pp. 802

Author(s):

Paul Rega ◽

Ken Krupp ◽

Kris Brickman ◽

Jan Alexander ◽

Michael Guinness

Keyword(s):

Bone Marrow ◽

Bone Marrow Study

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Clinical and Immunologic Features of Miliary Tuberculosis withPositive Bone Marrow Study

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.1996.43.1.22 ◽

1996 ◽

Vol 43 (1) ◽

pp. 22

Author(s):

Kwang Seon Song ◽

Suk Joong Yong ◽

Kye Chul Shin ◽

Won Yeon Lee ◽

Jeong Seon Ryu

Keyword(s):

Bone Marrow ◽

Miliary Tuberculosis ◽

Bone Marrow Study

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Sites of aluminum accumulation in bone marrow: study using electron microscopy, ionic microscopy and X-ray microanalysis

Biology of the Cell ◽

10.1111/j.1768-322x.1986.tb00464.x ◽

1986 ◽

Vol 57 (1) ◽

pp. 63-75 ◽

Cited By ~ 12

Author(s):

A. Watrin ◽

P. Galle

Keyword(s):

Electron Microscopy ◽

Bone Marrow ◽

X Ray ◽

Bone Marrow Study ◽

Aluminum Accumulation

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Characterization of a novel decellularized bone marrow scaffold as an inductive environment for hematopoietic stem cells

Biomaterials Science ◽

10.1039/c8bm01503a ◽

2019 ◽

Vol 7 (4) ◽

pp. 1516-1528 ◽

Cited By ~ 4

Author(s):

Juares E. Romero Bianco ◽

Renata Giardini Rosa ◽

Ada Congrains-Castillo ◽

Paulo P. Joazeiro ◽

Stephen D. Waldman ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Hematopoietic Stem Cells ◽

Bovine Bone ◽

Hematopoietic Stem ◽

Bone Marrow Study ◽

Increasing Demand

Due to the increasing demand for a bone marrow study model, we developed a natural scaffold from decellularized bovine bone marrow (DeBM).

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A Statistical Analysis on Clinical Implication of Bone Marrow Study: A Single Institute Data

Annals of Oncology ◽

10.1093/annonc/mdt460.100 ◽

2013 ◽

Vol 24 ◽

pp. ix86

Author(s):

J.J. Ho ◽

J.Y. Kim ◽

J.D. Kim ◽

P.L. Chun ◽

K. Seok-Hyun ◽

...

Keyword(s):

Bone Marrow ◽

Statistical Analysis ◽

Clinical Implication ◽

Bone Marrow Study

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Clinico-haematological profile of adult pancytopenia patients at a tertiary care institute in South India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210435 ◽

2021 ◽

Vol 9 (2) ◽

pp. 521

Author(s):

Nadia Shafi Chikan ◽

Qazi Mohammad Iqbal ◽

Altaf Hussain Mir

Keyword(s):

Bone Marrow ◽

Megaloblastic Anemia ◽

Tertiary Care ◽

Bone Marrow Examination ◽

Hematological Disorders ◽

Medical College ◽

Haematological Profile ◽

Bone Marrow Study ◽

Hypercellular Marrow ◽

Rule Out

Background: Pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leukopenia and thrombocytopenia resulting from a number of disease processes. Varieties of hematological and non-hematological disorders may affect bone marrow either primarily or secondarily, resulting in the manifestation of pancytopenia. The incidence of various hematological disorders causing pancytopenia varies due to geographical distribution and genetic predisposition. This study highlights the spectrum of causes, clinical presentation and bone marrow morphology of pancytopenia.Methods: This prospective observational study was conducted for a period of two years at Al-Ameen Medical College, Bijapur, Bangalore. During this period, fifty patients with a hematological diagnosis of pancytopenia were studied during period in the department of pathology.Results: Among the 50 cases studied, 35 were males and 15 were females. Most of the patients presented with generalized weakness and fever. The commonest physical finding was pallor, followed by splenomegaly and hepatomegaly. Dimorphic anemia was predominant blood picture. Bone marrow study showed 72% hypercellular marrow, 12% normocellular and 16% hypocellular marrow. The commonest cause for pancytopenia was megaloblastic anemia followed by iron deficiency anaemia and malaria.Conclusions: The present study concludes that detailed hematological investigations along with bone marrow examination in pancytopenic patients is helpful to diagnose or rule out the causes of pancytopenia.

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Effectiveness of Dexamethasone compared with Prednisolone in Induction Therapy of Childhood Acute Lymphoblastic Leukemia

Journal of Paediatric Surgeons of Bangladesh ◽

10.3329/jpsb.v6i1.27740 ◽

2016 ◽

Vol 6 (1) ◽

pp. 3-9

Author(s):

Tofazzal Hossain ◽

MA Mannan ◽

Shamsoon Nahar ◽

AKM Amirul Morshed ◽

Shahnoor Islam ◽

...

Keyword(s):

Bone Marrow ◽

Acute Lymphoblastic Leukemia ◽

Induction Therapy ◽

Lymphoblastic Leukemia ◽

Blast Cell ◽

Newly Diagnosed ◽

Significant Difference ◽

Group A ◽

Bone Marrow Study ◽

Group B

Background: Corticosteroids are an essential component of treatment for acute lymphoblastic leukemia (ALL). Prednisolone is the most commonly used steroid. There is increasing evidence that, even in equipotent dosage for glucocorticoid effect, dexamethasone has enhanced lymphoblast cytotoxicity and penetration of central nervous system compared with prednisolone.Objectives: To determine the effect of dexamethasone and prednisolone and to compare them in induction therapy of ALL in Children.Material & Methods: A total of 60 newly diagnosed cases of ALL confirmed by bone marrow study, children of either sex with age >1 year were included in this study. Variables studied were age, sex, presenting features, neutrophil count, blast cell count, platelet count, bone marrow status at diagnosis, on D15 & D29 of induction and side effects.Results: Mean age of the patients of group A was 6.28 years & that of group B was 7.2 years. Out of all patients of group A 19 (63.3%) were male and 11 (36.7%) were female. In group B 21 (70.0%) patients were male and rests 9 (30.3%) were female. No statistically significant difference was observed in both groups in terms of age, sex & presenting features. After induction significant difference was observed in liver & spleen size at day 7 and day 15. All patients of both groups had M3 marrow status at diagnosis. Overall, in group A 93.3% patients achieved M1 marrow status (fewer than 5% blasts) and 6.7% had M2 marrow status (5-25% blasts) at day 15 of induction. On the other side 66.7% patients of group B achieved M1 status and 33.3% M2 status at day 15. Statistically significant difference was observed between groups on day 15 in term of achieved marrow status (p<0.05). No statistically significant difference was observed between groups in term of infection in difference days of induction. On day 16 of induction maximum incidence of infection was observed in both groups.Conclusion: Dexamethasone may be an effective alternative option to prednisolone for the treatment of acute lymphoblastic leukemia in children.J. Paediatr. Surg. Bangladesh 6(1): 3-9, 2015 (Jan)

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Study of etiological spectrum and clinical profile of patients admitted in tertiary care hospital of South Gujarat, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201110 ◽

2020 ◽

Vol 7 (4) ◽

pp. 616

Author(s):

Mohnish M. Patel ◽

K. N. Bhatt ◽

Khyati T. Jariwala

Keyword(s):

Bone Marrow ◽

Tertiary Care ◽

Peripheral Blood Smear ◽

Megaloblastic Anaemia ◽

Care Hospital ◽

Peripheral Smear ◽

Normal Reference Range ◽

Common Cause ◽

Etiological Spectrum ◽

Bone Marrow Study

Background: Pancytopenia is defined as reduction of all three formed elements of blood below normal reference range. The symptoms are fatigue, fever, dizziness and weight loss. Evaluation was done using complete hemogram and peripheral smear. The presenting marrow biopsy is most useful and accurate in evaluation of pancytopenia.Methods: Two ml of anticoagulated blood was collected for complete hemogram. The peripheral blood smear was stained with Leishman's stain and studied. Bone marrow biopsy and aspiration was done in all the patients to identify etiology.Results: Predominance was seen in the age group of 31-60 years. Most common cause of pancytopenia was megaloblastic anaemia in this study compared to other studies all over the world where most common cause was aplastic anaemia. This reflects higher prevalence of megaloblastic anaemia in the Indian subjects.Conclusions: A comprehensive clinical, haematological land bone marrow study of patients with pancytopenia usually helps in identification of the underlying cause.

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Bone marrow infiltration in infants with disseminated neuroblastoma

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.10056 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 10056-10056

Author(s):

B. De Bernardi ◽

S. Sorrentino ◽

M. Pasino ◽

A. R. Gigliotti ◽

D. Dau ◽

...

Keyword(s):

Bone Marrow ◽

Tumor Cell ◽

Tumor Cells ◽

Clinical Features ◽

Bone Marrow Infiltration ◽

Cell Aggregates ◽

Stage 4 ◽

Bone Marrow Study ◽

Definition Of ◽

Extensive Involvement

10056 Background: The INSS definition of stage 4S neuroblastoma allows a bone marrow infiltration (BMI) no greater than 10%. More extensive involvement is to be consider stage 4. However, the degree of BMI may be difficult to establish, since tumor cells in the marrow commonly aggregate in clumps. So far, no studies have specifically investigated this issue. In this study we have reviewed the bone marrow slides of infants with disseminated neuroblastoma enrolled between January 1998 and July 2008 in the Italian Neuroblastoma Registry. Methods: BMI was arbitrarily considered <10% when it consisted of a maximum of 5 tumor cell aggregates/slide in association to normal cellularity. Marrow was aspirated from iliac crests and slides were stained with Wright-Giemsa method. A minimum of 2 slides for aspirate were examined at low magnification. The same 2 hematologists (CR, MP) examined the slides independently along the study period, blind for clinical data. A third hematologist (FS) joined to perform the reviewing process. Results: Of 142 infants enrolled, we retrieved and reviewed bone marrow slides of 73. Before results of bone marrow study, 31 patients were defined as stage 4, and 42 as stage 4S. Following bone marrow study, 2 patients previously defined as stage 4S who had ≥10% BMI were moved to stage 4. The results of the revision are summarized ( Table ). Conclusions: In this study, only 2/42 infants with stage 4S clinical features had BMI ≥ 10% and were eventually labeled as stage 4. Whether chemotherapy for stage 4 is of advantage for these patients remains to be seen. [Table: see text] No significant financial relationships to disclose.

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