Basophils in the cerebrospinal fluid from a case of central nervous system leukemia

2021 ◽  
Author(s):  
Hongmei Ding ◽  
Lixia Zhang
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Leukemia

Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma.

1984 ◽  
Vol 2 (2) ◽  
pp. 98-101 ◽  
Author(s):  
S Amadori ◽  
G Papa ◽  
G Avvisati ◽  
M C Petti ◽  
M Motta ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Potential Role ◽  
High Dose ◽  
Effective Treatment Modality ◽  
Sequential Administration ◽  
Sequential Combination ◽  
Central Nervous System Leukemia ◽  
Meningeal Disease

Eight patients with overt central nervous system (CNS) leukemia and lymphoma were treated with sequential administration of systemic high-dose cytosine arabinoside (HiDAC) and asparaginase (ASP) with no direct CNS therapy. Complete clearing of the cerebrospinal fluid (CSF) was achieved in six (86%) of seven patients with meningeal disease, generally after the first course of therapy. Two patients presented with evidence of extensive intracerebral disease; both responded with a greater than 50% regression of the tumor infiltrates. Concomitant extraneurologic localizations responded equally well to HiDAC/ASP: responses were seen in four of five patients, including complete remission in three of four patients who presented with marrow involvement. Toxicity was generally moderate and limited to myelosuppression (eight of eight patients), tolerable nausea and vomiting (eight of eight patients), mild hepatotoxicity (two of eight patients), and oral mucositis (one of eight patients). These results indicate that HiDAC/ASP is a tolerable and highly effective treatment modality for CNS leukemia and lymphoma and suggest its potential role for sanctuary chemoprophylaxis.

Cerebrospinal fluid polyamine monitoring in central nervous system leukemia

1977 ◽  
Vol 75 (3) ◽  
pp. 365-369 ◽  
Author(s):  
Owen M. Rennert ◽  
Daniel L. Lawson ◽  
Jayesh B. Shukla ◽  
Thomas D. Miale
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Leukemia

Cerebrospinal Fluid Neopterin Levels in Children with Central Nervous System Leukemia

1993 ◽  
Vol 9 (4-5) ◽  
pp. 351-356 ◽  
Author(s):  
F. Millot ◽  
J. L. Dhondt ◽  
F. Mazingue ◽  
F. Mechinaud ◽  
J. L. Auget ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Leukemia

Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia

1991 ◽  
Vol 15 (2-3) ◽  
pp. 143-147 ◽  
Author(s):  
Eiichi Ishii ◽  
Shouichi Ohga ◽  
Ichirou Murano ◽  
Masao Kobayashi ◽  
Ken Kimura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Necrosis Factor ◽  
Central Nervous System Leukemia

CHAPTER 9: Immunology of TBEV-Infections

2020 ◽  
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Nk Cells ◽  
Peripheral Blood ◽  
Sample Collection ◽  
Tick Borne Encephalitis ◽  
Viral Infectious Disease ◽  
The Central Nervous System

Tick-borne encephalitis (TBE) is a viral infectious disease of the central nervous system caused by the tick-borne encephalitis virus (TBEV). TBE is usually a biphasic disease and in humans the virus can only be detected during the first (unspecific) phase of the disease. Pathogenesis of TBE is not well understood, but both direct viral effects and immune-mediated tissue damage of the central nervous system may contribute to the natural course of TBE. The effect of TBEV on the innate immune system has mainly been studied in vitro and in mouse models. Characterization of human immune responses to TBEV is primarily conducted in peripheral blood and cerebrospinal fluid, due to the inaccessibility of brain tissue for sample collection. Natural killer (NK) cells and T cells are activated during the second (meningo-encephalitic) phase of TBE. The potential involvement of other cell types has not been examined to date. Immune cells from peripheral blood, in particular neutrophils, T cells, B cells and NK cells, infiltrate into the cerebrospinal fluid of TBE patients.

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