Performance of the Sysmex White Precursor Channel to discover circulating leukemic blast cells

2020 ◽  
Vol 42 (6) ◽  
pp. 734-743
Author(s):  
Jesper Sejrup ◽  
David M. Pedersen ◽  
Jens P. Phillipsen ◽  
Jesper Ø. Nielsen ◽  
Sheila P. R. Koch ◽  
...  
Keyword(s):  
Leukemic Blast ◽  
Blast Cells

Use of the mtt assay for rapid determination of chemosensitivity of human leukemic blast cells

1988 ◽  
Vol 12 (10) ◽  
pp. 823-831 ◽  
Author(s):  
Barbara G. Campling ◽  
John Pym ◽  
Peter R. Galbraith ◽  
Susan P.C. Cole
Keyword(s):  
Mtt Assay ◽  
Rapid Determination ◽  
Leukemic Blast ◽  
Blast Cells

scholarly journals LEUKEMIC BLAST CELLS AND CONTROVERSIES IN MODELS OF HEMATOPOIESIS

2015 ◽  
Vol 37 (1) ◽  
pp. 2-4 ◽  
Author(s):  
D F Gluzman ◽  
L M Sklyarenko ◽  
M P Zavelevich ◽  
S V Koval ◽  
T S Ivanivskaya
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Leukemic Blast ◽  
Acute Leukemias ◽  
Cell Lineages ◽  
Hematopoietic Lineage ◽  
Acute Monoblastic Leukemia ◽  
Blast Cells ◽  
The Common ◽  
Insight Into

Classical and up-to-date models of hematopoietic lineage determination are briefly reviewed with the focus on myeloid-based models challenging the existence of the common progenitor for T cells, B cells and NK cells. The analysis of immunophenotype of leukemic blast cells seems to be a promising approach for interpreting some controversies in the schemes of normal hematopoiesis. The liter ature data as well as our own findings in the patients with various types of acute leukemias are in favor of the concept postulating that common myeloid-lymphoid progenitors giving rise to T and B cell branches retain the myeloid potential. The similarity of some immunophenotypic features of blast cells in pro-B acute lymphoblastic leukemia and acute monoblastic leukemia is consistent with monocyte origin postulated in the studies of normal hematopoiesis. Study of acute leukemias may be the challenging area of research allowing for new insight into the origin of hematopoietic cell lineages.

scholarly journals Lineage infidelity following exposure of T lymphoblasts (MOLT-3 cells) to 5-azacytidine

Blood ◽  
1984 ◽  
Vol 63 (6) ◽  
pp. 1324-1330 ◽  
Author(s):  
LJ Smith ◽  
EA McCulloch
Keyword(s):  
Gene Expression ◽  
Monoclonal Antibodies ◽  
T Cell ◽  
Leukemic Blast ◽  
Continuous Line ◽  
Single Exposure ◽  
Cell Lineages ◽  
Lineage Infidelity ◽  
Blast Cells ◽  
T Lymphoblasts

Abstract The appearance on single leukemic blast cells of markers of at least two different lineages has been termed lineage infidelity. MOLT-3 cells, a continuous line of human T lymphoblasts, express T cell markers as defined immunologically with monoclonal antibodies. Following a single exposure to 5-azacytidine, other markers, usually associated with non-T cell lineages, appeared transiently. A stable clone with lineage infidelity was obtained by selection from colonies expressing novel markers. Marker expression followed reproducible kinetics during growth. 5-Azacytidine-treated MOLT-3 subclones may be useful models in the study of lineage infidelity and gene expression.

Proliferation, Differentiation Arrest, and Survival in Leukemic Blast Cells

1992 ◽  
Vol 663 (1 Aging and Cel) ◽  
pp. 202-214 ◽  
Author(s):  
S. FERRARI ◽  
R. MANFREDINI ◽  
A. GRANDE ◽  
G. TORELLI ◽  
U. TORELLI
Keyword(s):  
Leukemic Blast ◽  
Blast Cells

scholarly journals Autologous leukemia-specific T-cell-mediated lymphocytotoxicity in patients with acute myelogenous leukemia.

1978 ◽  
Vol 147 (3) ◽  
pp. 912-922 ◽  
Author(s):  
S K Lee ◽  
R T Oliver
Keyword(s):  
Acute Myelogenous Leukemia ◽  
Blast Cell ◽  
Third Party ◽  
Myelogenous Leukemia ◽  
Target Antigen ◽  
Leukemic Blast ◽  
Crossover Studies ◽  
Acute Myelogenous ◽  
Blast Cells ◽  
Short Term Culture

Short-term culture of acute myelogenous leukemia patient's remission lymphocytes with inactivated autologous leukemic blast cells plus allogeneic lymphocytes, generated effector T lymphocytes which were cytotoxic for the specific autologous blast cell in 11 of 14 patients studied. Experiments using Daudi and Molt 4 lymphoblastoid cell lines as third-party helper cell suggest that an HLA D locus incompatability is necessary to provide effective help in this system. Cold target inhibition experiments, crossover studies between pairs of patients, and experiments with allogeneic leukemic blast cells as priming stimulus suggest that the target antigen is only present on the specific autologous blast cell.

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