Red blood cell distribution width: can it be a predictive marker for long-term valvular involvement in children with acute rheumatic carditis?

2016 ◽  
Vol 38 (5) ◽  
pp. 569-575 ◽  
Author(s):  
M. Kucuk ◽  
R. Ozdemir ◽  
C. Karadeniz ◽  
K. Celegen ◽  
M. Demirol ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Predictive Marker ◽  
Cell Distribution ◽  
Rheumatic Carditis ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-23 ◽  
Author(s):  
Ning Li ◽  
Heng Zhou ◽  
Qizhu Tang
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Complete Blood Count ◽  
Predictive Marker ◽  
Biochemical Parameter ◽  
Cerebrovascular Diseases ◽  
Deficiency Anemia ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The red blood cell distribution width (RDW) obtained from a standard complete blood count (CBC) is a convenient and inexpensive biochemical parameter representing the variability in size of circulating erythrocytes. Over the past few decades, RDW with mean corpuscular volume (MCV) has been used to identify quite a few hematological system diseases including iron-deficiency anemia and bone marrow dysfunction. In recent years, many clinical studies have proved that the alterations of RDW levels may be associated with the incidence and prognosis in many cardiovascular and cerebrovascular diseases (CVDs). Therefore, early detection and intervention in time of these vascular diseases is critical for delaying their progression. RDW as a new predictive marker and an independent risk factor plays a significant role in assessing the severity and progression of CVDs. However, the mechanisms of the association between RDW and the prognosis of CVDs remain unclear. In this review, we will provide an overview of the representative literatures concerning hypothetical and potential epidemiological associations between RDW and CVDs and discuss the underlying mechanisms.

scholarly journals Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2274
Author(s):  
Satoshi Ebata ◽  
Ayumi Yoshizaki ◽  
Takemichi Fukasawa ◽  
Asako Yoshizaki-Ogawa ◽  
Yoshihide Asano ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Blood Cell ◽  
Lung Disease ◽  
Red Blood Cell ◽  
First Year ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) varies among individuals. Red blood cell distribution width (RDW) has been reported to be a predictor of idiopathic pulmonary fibrosis. However, there are no studies on the relationship between RDW and SSc-ILD. We conducted a retrospective study of 28 patients who were diagnosed with SSc-ILD on their first visit to our hospital and were followed-up for 5 years. The correlation between the changes in RDW, KL-6, and SP-D (ΔRDW, ΔKL-6, ΔSP-D) and the changes in percent-predicted forced lung volume and % carbon monoxide diffusion (Δ%FVC, Δ%DLco) was investigated. ΔRDW at 1 year after diagnosis was significantly inversely correlated with Δ%FVC at 5 years after diagnosis (r = −0.51, p < 0.001) and Δ%DLco at 5 years after diagnosis (r = −0.47, p < 0.001), whereas ΔKL-6 and ΔSP-D at 1 year were not correlated with Δ%FVC or Δ%DLco at 5 years. In the group of SSc-ILD patients with RDW increase in the first year after diagnosis, %FVC and %DLco were significantly lower than baseline at 3-, 4-, and 5-year assessments. In the group of patients without RDW increase in the first year, %FVC and %DLco did not decrease during the follow-up period. In conclusion, the changes in RDW in the first year after diagnosis may be useful surrogate markers to predict the long-term course of SSc-ILD.

scholarly journals Red blood cell distribution width as a predictor of long-term mortality in patients with carbon monoxide poisoning

2018 ◽  
Vol 18 (4) ◽  
pp. 158-161 ◽  
Author(s):  
Hamza Sunman ◽  
Tolga Çimen ◽  
Mehmet Erat ◽  
Kadriye Gayretli Yayla ◽  
Tolga Han Efe ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Carbon Monoxide Poisoning ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution ◽  
Long Term Mortality

Red blood cell distribution width as a predictor of long term outcome of celiac disease

2017 ◽  
Vol 49 (4) ◽  
pp. e272
Author(s):  
G. Paiola ◽  
G. Tezza ◽  
G. Turcato ◽  
M. Deganello Saccomani ◽  
C. Banzato
Keyword(s):  
Celiac Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Term Outcome ◽  
Distribution Width ◽  
Long Term Outcome ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width as a 5-Year Prognostic Marker in Patients Submitted to Carotid Endarterectomy

2020 ◽  
Vol 10 (3) ◽  
pp. 181-192
Author(s):  
Luís Duarte-Gamas ◽  
António Pereira-Neves ◽  
Filipa Jácome ◽  
Mariana Fragão-Marques ◽  
Ricardo P. Vaz ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Full Blood Count ◽  
Cell Distribution ◽  
Distribution Width ◽  
Cox Regression Analysis ◽  
All Cause Mortality ◽  
Red Blood Cell Distribution ◽  
Long Term Mortality

<b><i>Objective:</i></b> Patients submitted to carotid artery endarterectomy (CEA) have a long-term risk of major adverse cardiovascular events (MACE) of 6–9% at 2 years. Hematological parameters have been shown to have a predictive function in atherosclerotic diseases, namely the red blood cell distribution width-coefficient of variation (RDW-CV). This parameter has been associated with worse outcomes such as myocardial infarction (MI), stroke, and all-cause mortality. This study aims to evaluate the potential role of preoperative hematologic parameters such as RDW-CV in predicting perioperative and long-term cardiovascular adverse events and mortality in patients submitted to CEA. <b><i>Methods:</i></b> From January 2012 to January 2019, 180 patients who underwent CEA with regional anesthesia in a tertiary care and referral center were selected from a prospective cohort database. Blood samples were collected preoperatively 2 weeks before admission, including a full blood count. The primary outcome included long-term MACE. Secondary outcomes included all-cause mortality, stroke, MI, acute heart failure, and major adverse limb events (MALE). <b><i>Results:</i></b> At baseline, 27.2% of patients had increased RDW-CV. Increased RDW-CV was independently associated with baseline hemoglobin (adjusted odds ratio [aOR] 0.715, 95% CI 0.588–0.869, <i>p</i> = 0.001) and atrial fibrillation (aOR 4.028, 95% CI 1.037–15.639, <i>p</i> = 0.001). After a median follow-up of 50 months, log-rank univariate analysis of RDW-CV demonstrated a significant association between increased RDW-CV and long-term all-cause mortality (log-rank &#x3c;0.001), MACE (log-rank &#x3c;0.001), and MI (log-rank = 0.017). After multivariate Cox regression analysis, increased RDW-CV was associated with increased long-term mortality (adjusted hazard ratio [aHR] 2.455, 95% CI 1.231–4.894, <i>p</i> = 0.011) and MACE (aHR 2.047, 95% CI 1.202–3.487, <i>p</i> = 0.008). A decreased hemoglobin to platelet ratio (aHR 2.650e–8, 95% CI 9.049e–15 to 0.078, <i>p</i> = 0.019) was also associated with all-cause mortality. <b><i>Conclusion:</i></b> RDW is a widely available and low-cost marker that independently predicts long-term mortality, MACE, and MI after CEA. This biomarker could prove useful in assessing which patients would likely benefit from CEA in the long term.

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